Nociceptin-induced modulation of human T cell function

Easten, Kate H.; Harry, Rachel A.; Purcell, Wendy M.; McLeod, Julie D.

Abstract

There is an accumulating evidence for the immunoregulatory role of the neuropeptide, nociceptin/orphanin FQ (N/OFQ) however its role on T cell function requires elucidation. This study has demonstrated an inhibitory role for N/OFQ on SEB-activated T cell function. N/OFQ decreases T cell proliferation, which is abrogated when the costimulatory receptors CD80 and CD86 are blocked. In addition, evidence suggests that the immunoregulatory cytokines TGF-β, IFN-γ and nitric oxide (NO) are involved in the N/OFQ effect. N/OFQ also, through involvement of IFN and NO, induces the expression of the immunosuppressive modulator indoleamine 2,3-dioxygenase (IDO), suggesting a central role for IDO in the N/OFQ effect on T cell proliferation. The data presented in this report indicate a multi-faceted mechanism of action used by N/OFQ to modulate T cell function. © 2009 Elsevier Inc. All rights reserved.

Citation

Easten, K. H., Harry, R. A., Purcell, W. M., & McLeod, J. D. (2009). Nociceptin-induced modulation of human T cell function. Peptides, 30(5), 926-934. https://doi.org/10.1016/j.peptides.2009.01.021

• Journal Article Type: Article
• Publication Date: May 1, 2009
• Journal: Peptides
• Print ISSN: 0196-9781
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 5
• Pages: 926-934
• DOI: https://doi.org/10.1016/j.peptides.2009.01.021
• Keywords: nociceptin, IDO, IFN-γ, T cells, neuropeptides, SEB
• Public URL: https://uwe-repository.worktribe.com/output/1002225
• Publisher URL: http://dx.doi.org/10.1016/j.peptides.2009.01.021