All Outputs (1073)

Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses (2023)
Thesis

Confronted with DNA damage, cells can undergo cell cycle arrest and DNA repair, or cell death. However, communal DNA damage response (DDR) proteins involved in each of these cell fates, has confounded attempts to unravel the molecular nuances that dr... Read More about Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses.

The spatio-temporal influence of atmospheric circulations on hydroclimate in Great Britain (2023)
Thesis

Atmospheric circulations have an important influence on regional climate. Understanding the relationships between circulations, rainfall and streamflow at a regional and catchment scale is therefore of interest to water and environmental managers. Ho... Read More about The spatio-temporal influence of atmospheric circulations on hydroclimate in Great Britain.

The development of environmental DNA (eDNA) techniques for the detection and monitoring of the critically endangered European eel, Anguilla anguilla (2023)
Thesis

The European eel Anguilla anguilla, is currently classified as critically endangered (IUCN Red List). In the UK the eel population is estimated at less than 5% of numbers observed in the 1980s and this trend is reflected throughout its European fresh... Read More about The development of environmental DNA (eDNA) techniques for the detection and monitoring of the critically endangered European eel, Anguilla anguilla.

The Feral MBA (2023)
Thesis

The Feral MBA investigates what taking business as medium for artistic inquiry might open up, both in relation to arts livelihoods and to the ways that business and economy are performed in other areas. This practice-based research is rooted in three... Read More about The Feral MBA.

An industrial craft reinstated: A printmaker's perspective on tissue transferware (2023)
Thesis

Underglaze tissue transfer printing, termed transferware, is a genre of industrial printmaking on ceramics. This genre was practiced inside the factory and is described in my doctoral study as an industrial craft. Much of the knowledge surrounding th... Read More about An industrial craft reinstated: A printmaker's perspective on tissue transferware.

A BIM-based information management schema for construction activities data-flow across the project life cycle (2023)
Thesis

Excellent communication among project participants is critical to successful implementation of construction projects. However, the vast amount and variety of information and the physical dispersion of construction sites obstruct the flow and exchange... Read More about A BIM-based information management schema for construction activities data-flow across the project life cycle.

Why regulate at all? A critical analysis of the rationale and effectiveness of UK bank regulation (2023)
Thesis

The Global Financial Crisis (GFC) represented the biggest shock to the world economy since the Wall Street Crash of 1929 and subsequent banking crisis that precipitated the Great Depression of the 1930’s. Since this event the debate on the structure... Read More about Why regulate at all? A critical analysis of the rationale and effectiveness of UK bank regulation.

The sexual health experiences and motivators of Black heterosexual men in London. A qualitative study including higher-risk behaviours (2023)
Thesis

Background: Black ethnic groups in the UK disproportionately experience poor sexual health outcomes. This appears to be more pronounced amongst Black men and has been attributed to a complex interplay of individual, behavioural, cultural and structur... Read More about The sexual health experiences and motivators of Black heterosexual men in London. A qualitative study including higher-risk behaviours.

Recovery from alcohol and the relationship with the self: Insights from long-term counselling clients (2023)
Thesis

The present study explores the experience of recovering from alcohol dependence from the perspectives of people who have received long-term therapeutic work. Diverting from the existing literature that focuses solely on the perspective of AA members,... Read More about Recovery from alcohol and the relationship with the self: Insights from long-term counselling clients.

Evaluating the graphics processing unit for digital audio synthesis and the development of HyperModels (2023)
Thesis

The extraordinary growth in computation in single processors for almost half a century is becoming increasingly difficult to maintain. Future computational growth is expected from parallel processors, as seen in the increasing number of tightly coup... Read More about Evaluating the graphics processing unit for digital audio synthesis and the development of HyperModels.

"Storying the unstoried" Experiences of organisational change: How can team interventions using story disruption change sensemaking? (2023)
Thesis

A series of interventions based on storytelling and restorying were used to explore how two teams made sense of their experiences during organisational changes. Seven monthly collaborative interventions were run with each team, facilitating the telli... Read More about "Storying the unstoried" Experiences of organisational change: How can team interventions using story disruption change sensemaking?.

An investigation of interventions for the reduction of traffic-related air pollution at schools in England (2023)
Thesis

Children are particularly vulnerable to the negative effects of air pollution exposure due to their developing lungs and their greater respiratory rate than adults. The school commute presents a period of particular threat because children are expose... Read More about An investigation of interventions for the reduction of traffic-related air pollution at schools in England.

Defining and refining nurse-led care for people with early rheumatoid arthritis (2023)
Thesis

Nurse-led care in rheumatoid arthritis (RA) has been shown to be effective. However, the role of the nurse in early RA is not well-defined, and it is not known how well care needs are met in early RA nurse-led care. This PhD research aims to provide... Read More about Defining and refining nurse-led care for people with early rheumatoid arthritis.

An evaluation of different methodologies employed to investigate the effects of mixing alcohol with energy drink (2023)
Thesis

The increase in popularity of AMED consumption among young people in the past decade has led to public health concerns regarding its use. It has been suggested that the stimulant effects of caffeine in energy drinks may counteract the sedative effect... Read More about An evaluation of different methodologies employed to investigate the effects of mixing alcohol with energy drink.

Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease (2023)
Thesis

Introduction: Oxidative stress and impaired homeostasis are key features of type 2 diabetes mellitus, which is comorbid with Alzheimer’s disease. Dysregulation of the branched-chain aminotransferase protein, which is overexpressed in AD, is suggested... Read More about Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease.

How do an individual’s values drive their involvement to develop a sustainable community business? (2023)
Thesis

Community businesses (CB) are not-for-profit trading organisations created to serve a purpose: geographically situated, contextually embedded and accountable to the local community that they serve. Despite their vital role within their communities,... Read More about How do an individual’s values drive their involvement to develop a sustainable community business?.

Understanding how social networking sites influence adolescent body image, wellbeing, and psychosocial functioning (2023)
Thesis

Social networking sites (SNS) are used by a significant proportion of the population. A large body of literature has highlighted the relationship between SNS use and increased body image concerns, decreased wellbeing, and a diverse range of offline b... Read More about Understanding how social networking sites influence adolescent body image, wellbeing, and psychosocial functioning.

Adapting interfaces to induce behaviour change and mitigate the negative effects of interruptions in safety critical healthcare settings (2023)
Thesis

Due to the fast-paced, dynamic, and sometimes unpredictable nature of the environment’s healthcare professionals work within, it is inevitable that task interruptions will occur. Such clinical task interruptions are consistently cited as a contributi... Read More about Adapting interfaces to induce behaviour change and mitigate the negative effects of interruptions in safety critical healthcare settings.

The experiences of young Somali adults with visible facial differences (2023)
Thesis

Background: The term visible difference refers to an appearance that is considered different to the societal ‘norm’, including skin conditions and scars. The psychosocial impact of living with a visible difference is well-documented in the literature... Read More about The experiences of young Somali adults with visible facial differences.

The role of cognitive functioning in predicting health outcomes of cardiac rehabilitation patients (2023)
Thesis

Cardiovascular disease (CVD), characterized by a narrowing of arteries due to the build-up of plaque, is the most common cause of death worldwide, being responsible for an estimated 17.9 million death each year. Cardiac Rehabilitation (CR) is a multi... Read More about The role of cognitive functioning in predicting health outcomes of cardiac rehabilitation patients.