Genotoxicity testing is required for all new compounds utilising 2D assays, such as the in vitro micronucleus (MN) assay, before moving to in vivo assays such as the rodent bone marrow MN assay. Two-dimensional cell culture has traditionally been use... Read More about Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing.
All Outputs (1083)
A processual account of organisational change: Focusing attention on interaction and emergence (2021)
Thesis
This research proposes organisational change as unpredictable, uncontrollable and emergent, through the changing patterns of relating between participants. This contrasts with prescribed frameworks such as Six Sigma, which use a structured DMAIC (def... Read More about A processual account of organisational change: Focusing attention on interaction and emergence.
In the field of architecture, there has been little research on how the accumulation of material possessions is impacting on space for living in the home. There has been little understanding of what households own, collect, store and dispose of, nor... Read More about Stuff and space in the home: How can an understanding of material possessions help to inform spatial storage design in UK housing?.
A web-based Decision Support System (DSS) for preliminary risk assessment of Brownfield sites (2021)
Thesis
Reusing brownfield sites always raises concern for the health and safety of site workers involved in site renovations and redevelopments and, subsequently, for the residents or occupants of the sites. As a minimum, a preliminary risk assessment is ne... Read More about A web-based Decision Support System (DSS) for preliminary risk assessment of Brownfield sites.
Homing of haematopoietic stem cells (HSCs) to the bone marrow (BM) niches after transplantation (HSCT) is controlled by chemotactic signalling released from the BM microenvironment. This process is incompletely understood, but some factors are known,... Read More about Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface.
This research thesis qualitatively explores young peoples’ lived experiences of transitioning from Child and Adolescent Mental Health Services (CAMHS) provided by the National Health Service (NHS) into voluntary and charitable sector services. Within... Read More about The transition from statutory Child and Adolescent Mental Health Services into third sector voluntary and charitable services: An interpretative phenomenological analysis of young peoples’ experiences.
Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1.
SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.
While most education professionals report their straightforward enactment of Prevent, a critical multilevel analysis of 17 interviews with education professionals in the Bath and Bristol areas of the UK data demonstrates however, that the policy is w... Read More about Counter-terrorism measures in the classroom: Exploring the perceptions and experiences of education professionals enacting the Prevent Duty in Bath and Bristol.
Noise and morphogenesis: Uncertainty, randomness and control (2021)
Thesis
This thesis presents a processual ontology of noise by virtue of which morphogenesis (in its most general understanding as the processes by which order/form is created) must be instantiated. Noise is here outlined as the far from equilibrium environm... Read More about Noise and morphogenesis: Uncertainty, randomness and control.
Capital structure and firm growth: The case of Vietnamese listed firms (2021)
Thesis
This thesis provides a wide range of research on capital structure within the context of Vietnamese listed firms through three specific empirical studies. The first study focuses on analysing the adjustment process of capital structure towards the ta... Read More about Capital structure and firm growth: The case of Vietnamese listed firms.
This thesis is a practice-led enquiry that investigates the creative potential of pinhole video, a new imaging technique which is undocumented elsewhere. Although fixed pinhole image capture has been possible since the advent of chemical photography... Read More about Lens-less capture and emerging moving imaging technologies: An investigation into the ways in which digital pinhole capture and advances in lens-less capture in imaging technologies may affect the form and content of moving images.
A generic provenance framework to document public policy making processes (2021)
Thesis
Public policies impact the day to day activities of individuals. Effective public policy outcomes result in general acceptance among the community. The transparency in policy making process and participation during policy creation holds significant p... Read More about A generic provenance framework to document public policy making processes.
Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.
The role of earnings and its components in predicting future cash flows: Evidence from the MENA region firms (2021)
Thesis
This thesis aims to examine the role of current earnings and its components - cash flows and accruals- in predicting the one-year-ahead cash flows from operations (CFO) in the MENA region country firms for the sample period 2005 to 2018. In order to... Read More about The role of earnings and its components in predicting future cash flows: Evidence from the MENA region firms.
Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.
Exploring men’s experiences of their female partner’s sexual pain: A qualitative thematic analysis study (2021)
Thesis
Aims
Female sexual pain occurs within a relational context, yet little is known about partners’ experiences This study adds to the very small literature exploring men’s experience of sexual pain within a different-sex relationship. I aimed to give v... Read More about Exploring men’s experiences of their female partner’s sexual pain: A qualitative thematic analysis study.
‘In my own comfort zone’: Client experiences of relational aspects of Skype therapy for alcohol problems (2021)
Thesis
Background: therapists and counsellors are increasingly using Skype or equivalent video-based applications to offer treatment in place of face-to-face delivery of talking therapies. In the alcohol treatment sector, this offers a range of potential be... Read More about ‘In my own comfort zone’: Client experiences of relational aspects of Skype therapy for alcohol problems.
Iranian immigrant women’s experiences of domestic violence: An interpretative phenomenological analysis (2021)
Thesis
Domestic violence is a major social health problem. Intimate partner violence is one of the most common forms of violence against women worldwide. Domestic violence against groups of immigrant women in heterosexual relationships has been explored; ho... Read More about Iranian immigrant women’s experiences of domestic violence: An interpretative phenomenological analysis.
Ethical implications of artificial expression of emotion by social robots in assistive contexts (2021)
Thesis
This research investigated whether Artificial Expression of Emotion (AEE) by a social robot can lead to emotional deception and emotional attachment. The use of AEE can be beneficial, as it may encourage engagement, and can help to build trust in the... Read More about Ethical implications of artificial expression of emotion by social robots in assistive contexts.
This thesis examines the implementation of the international Anti-Money Laundering (AML) standards regarding the role of Financial Intelligence Units (FIU) under the Financial Action Task Force (FATF) Recommendations. The main research questions focu... Read More about Financial intelligence units and the prevention of money laundering: A comparative analysis of financial intelligence units in the United Kingdom, Singapore and Thailand.