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All Outputs (39)

Near and far: Engaging children with place through Minecraft (2023)
Journal Article
Hobbs, L., Behenna, S., Bentley, S., & Stevens, C. (2023). Near and far: Engaging children with place through Minecraft. Geography, 108(3), 134-140. https://doi.org/10.1080/00167487.2023.2260221

Minecraft is an extremely popular computer game and educational tool. It provides various place-based facilities, with schools, towns and islands recreated, and geology and archaeology made available to explore in-game. In this ‘Spotlight On … ’ arti... Read More about Near and far: Engaging children with place through Minecraft.

Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool (2023)
Journal Article
May, J. E., Anderson, E., Clark, D., & Hull, J. (2023). Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool. British Journal of Biomedical Science, 80, Article 11756. https://doi.org/10.3389/bjbs.2023.11756

Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of many higher-level skills such as analysis and evaluation. It is hoped that these simulations... Read More about Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool.

Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation (2023)
Journal Article
Elkhenany, H., Elkodous, M. A., & Mansell, J. (2023). Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation. Nanomedicine, 18(21), 1459-1475. https://doi.org/10.2217/nnm-2023-0117

Aim: This study aimed to investigate the potential of ternary nanocomposite (TNC) to support MG63 osteoblast maturation to EB1089-(3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP) cotreatment. Materials & methods: Binary (P25/reduced gra... Read More about Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation.

Relationship between 3-meter backward walk test and grip strength in community-dwelling older adults (2023)
Journal Article
Mbada, C., Ozaveshe, A., Ademoyegun, A., Niyi-Odumosu, F., Akande, M., Gebrye, T., …Fatoye, F. (2023). Relationship between 3-meter backward walk test and grip strength in community-dwelling older adults. Advances in Rehabilitation, 37(3), 52-59. https://doi.org/10.5114/areh.2023.131722

Introduction: The 3-Meter Backward Walk Test (3-MBWT) is an important assessment tool used in evaluating neuromuscular control, proprioception, risk of fall and balance. On the other hand, the Hand Grip Strength (HGS) test primarily is used to measur... Read More about Relationship between 3-meter backward walk test and grip strength in community-dwelling older adults.

Putting food in the driver’s seat: Aligning food-systems policy to advance sustainability, health, and security (2023)
Journal Article
Andrews, E., Sanderson Bellamy, A., & Food Policy Alliance Cymru. (2023). Putting food in the driver’s seat: Aligning food-systems policy to advance sustainability, health, and security. Frontiers in Sustainable Food Systems, 7, Article 1204194. https://doi.org/10.3389/fsufs.2023.1204194

Food is a basic need, but seldom a basic policy area. Food systems are widely governed by disconnected policies distributed across a range of sectors including agriculture, education, health, environment, economy, and security. Failure to align food... Read More about Putting food in the driver’s seat: Aligning food-systems policy to advance sustainability, health, and security.

Advancing dysphagia-oriented multi-ingredient meal development: Optimising hydrocolloid incorporation in 3D printed nutritious meals (2023)
Journal Article
Εkonomou, S., Hadnađev, M., Gioxari, A., Abosede, O. R., Soe, S., & Stratakos, A. C. (2024). Advancing dysphagia-oriented multi-ingredient meal development: Optimising hydrocolloid incorporation in 3D printed nutritious meals. Food Hydrocolloids, 147, 109300. https://doi.org/10.1016/j.foodhyd.2023.109300

Dysphagia (DP) is a growing health concern in today's ageing population, leading to high demand for DP-oriented food. 3D printing is a promising novel technology for developing new attractive and appetising products. Therefore, we aimed to develop a... Read More about Advancing dysphagia-oriented multi-ingredient meal development: Optimising hydrocolloid incorporation in 3D printed nutritious meals.

Is there a role for citizen science in death and dying research? (2023)
Journal Article
Wilkinson, C., Llewellyn, A., & McCabe, C. (2023). Is there a role for citizen science in death and dying research?. Frontiers in Public Health, 11, Article 1241239. https://doi.org/10.3389/fpubh.2023.1241239

The COVID-19 pandemic has brought conversations about death and dying to the fore in a way not experienced for generations. This raises questions around perceptions of death and dying; the role of healthcare and the community in care; and the use of... Read More about Is there a role for citizen science in death and dying research?.

Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons (2023)
Journal Article
Ormond, M. J., Clement, N. D., Harder, B. G., Farrow, L., & Glester, A. (2023). Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons. Bone & Joint Open, 4(9), 696-703. https://doi.org/10.1302/2633-1462.49.bjo-2023-0070.r1

The principles of evidence-based medicine (EBM) are the foundation of modern medical practice. Surgeons are familiar with the commonly used statistical techniques to test hypoth-eses, summarize findings, and provide answers within a specified range o... Read More about Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons.

NOTCH and AKT signalling interact to drive mammary tumour heterogeneity (2023)
Journal Article
Ordonez, L., Tornillo, G., Kendrick, H., Hay, T., & Smalley, M. J. (2023). NOTCH and AKT signalling interact to drive mammary tumour heterogeneity. Cancers, 15(17), Article 4324. https://doi.org/10.3390/cancers15174324

A better understanding of the mechanisms generating tumour heterogeneity will allow better targeting of current therapies, identify potential resistance mechanisms and highlight new approaches for therapy. We have previously shown that in genetically... Read More about NOTCH and AKT signalling interact to drive mammary tumour heterogeneity.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article
Pisignano, G., Michael, D. C., Pirlog, R., Visal, T. H., Ladomery, M., & Calin, G. A. (2023). Going circular: history, present, and future of circRNAs in cancer. Oncogene, 42, 2783–2800. https://doi.org/10.1038/s41388-023-02780-w

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method (2023)
Journal Article
Ghodke, J., Ekonomou, S. I., Weaver, E., Lamprou, D., Doran, O., & Stratakos, A. C. (2023). The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method. Foods, 12(15), Article 2940. https://doi.org/10.3390/foods12152940

In this study, liposomes enclosing eugenol were prepared using microfluidics. Two lipids—1,2-dimyristoyl-sn-glycero-3-phosphocholine, 18:0 (DSPC) and 2-dimyristoyl-sn-glycero-3-phosphocholine, 14:0 (DMPC)—and microfluidic chips with serpentine and Y-... Read More about The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method.

Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds (2023)
Journal Article
Hunt, D., Dewar, A., Dal Molin, F., & Willey, N. (2023). Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds. Journal of Environmental Radioactivity, 268-269, Article 107261. https://doi.org/10.1016/j.jenvrad.2023.107261

With the rapidly expanding global nuclear industry, more efficient and direct radiological monitoring approaches are needed to ensure the associated environmental health impacts and risk remain fully assessed and undertaken as robustly as possible. C... Read More about Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds.

Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry (2023)
Journal Article
Sotom, M., Bowdler, P., & Honeychurch, K. C. (2023). Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry. Analytical Methods, 15(33), 4085-4093. https://doi.org/10.1039/D3AY00678F

A liquid chromatography-tandem mass spectrometry screening method in sweat was developed for the simultaneous determination of three licit drugs (nicotine, paracetamol, and caffeine); four illicit drugs (cocaine, ketamine, 25I-NBOMe and methamphetami... Read More about Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry.

Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources (2023)
Journal Article
Fatima, N., Emambux, M. N., Olaimat, A. N., Stratakos, A. C., Nawaz, A., Wahyono, A., …Shahbaz, H. M. (2023). Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources. Food and Humanity, 1, 731-741. https://doi.org/10.1016/j.foohum.2023.07.009

It is estimated that the world will need an extra 265 million tons of protein by the middle of this century, which is approximately 50 % more than today. Efforts are currently underway to find sustainable protein sources for keepin... Read More about Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article
Mansell, J. P., Tanatani, A., & Kagechika, H. (2023). An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation. Biomolecules, 13(7), Article 1113. https://doi.org/10.3390/biom13071113

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Ventilatory efficiency is reduced in people with hypertension during exercise (2023)
Journal Article
Hope, K., Chant, B., Hinton, T., Kendrick, A. H., Nightingale, A. K., Paton, J. F., & Hart, E. C. (2023). Ventilatory efficiency is reduced in people with hypertension during exercise. Journal of the American Heart Association, 12(13), Article e024335. https://doi.org/10.1161/JAHA.121.024335

BACKGROUND: An elevated ventilatory efficiency slope during exercise (minute ventilation/volume of expired CO2; VE /VCO2 slope) is a strong prognostic indicator in heart failure. It is elevated in people with heart failure with preserved ejection, ma... Read More about Ventilatory efficiency is reduced in people with hypertension during exercise.

Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow (2023)
Journal Article
Asurappulige, H. S. H., Thomas, A. D., & Morse, H. R. (2023). Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow. Mutagenesis, 38(4), 201-215. https://doi.org/10.1093/mutage/gead018

Donor cell leukaemia (DCL) is a complication of haematopoietic stem cell transplantation where donated cells become malignant within the patient's bone marrow. As DCL predominates as acute myeloid leukaemia, we hypothesized that the cytokine storm fo... Read More about Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow.

Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements (2023)
Journal Article
Azizova, L., Morgan, D., Rowlands, J., Brousseau, E., Kulik, T., Palianytsia, B., …Ayre, W. (2023). Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements. Orthopaedic Proceedings, 105-B(SUPP_9), 80-80. https://doi.org/10.1302/1358-992x.2023.9.080

Preventing infections in joint replacements is a major ongoing challenge, with limited effective clinical technologies currently available for uncemented knee and hip prostheses. This research aims to develop a coating for titanium implants, consisti... Read More about Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements.