Rachel M. Hagen
Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells
Hagen, Rachel M.; Chedea, Veronica S.; Mintoff, Christopher P.; Bowler, Elizabeth; Morse, H. Ruth; Ladomery, Michael R.; Ladomery, Michael
Authors
Veronica S. Chedea
Christopher P. Mintoff
Elizabeth Bowler
H. Ruth Morse
Michael R. Ladomery
Prof Michael Ladomery Michael.Ladomery@uwe.ac.uk
Professor of Genetics
Abstract
Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell survival was reduced and apoptosis increased significantly with a low dose of 1 μM EGCG. The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG. Furthermore, EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9.
Citation
Ladomery, M. R., Morse, H. R., Bowler, E., Mintoff, C. P., Chedea, V. S., Hagen, R. M., & Ladomery, M. (2013). Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. International Journal of Oncology, 43(1), 194-200. https://doi.org/10.3892/ijo.2013.1920
Journal Article Type | Article |
---|---|
Publication Date | Jul 1, 2013 |
Journal | International Journal of Oncology |
Print ISSN | 1019-6439 |
Electronic ISSN | 1791-2423 |
Publisher | Spandidos Publications |
Peer Reviewed | Peer Reviewed |
Volume | 43 |
Issue | 1 |
Pages | 194-200 |
DOI | https://doi.org/10.3892/ijo.2013.1920 |
Keywords | Epigallocatechin-3-gallate, apoptosis, expression, caspase 9a splice variant, PC3 prostate cancer cells |
Public URL | https://uwe-repository.worktribe.com/output/930368 |
Publisher URL | http://dx.doi.org/10.3892/ijo.2013.1920 |
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