Nick A. Maskell
Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection
Maskell, Nick A.; Zahan-Evans, Natalie; Harvey, John E.; Medford, Andrew R.L.; Clive, Amelia O.; Edey, Anthony J.; Hooper, Clare E.; Hooper, Clare E; Edey, Anthony J; Wallis, Anthony; Clive, Amelia O; Morley, Anna; White, Paul; Medford, Andrew R L; Harvey, John E; Darby, Mike; Zahan Evans, Natalie; Maskell, Nick A
Authors
Natalie Zahan-Evans
John E. Harvey
Andrew R.L. Medford
Amelia O. Clive
Anthony J. Edey
Clare E. Hooper
Clare E Hooper
Anthony J Edey
Anthony Wallis
Amelia O Clive
Anna Morley
Paul White Paul.White@uwe.ac.uk
Professor in Applied Statistics
Andrew R L Medford
John E Harvey
Mike Darby
Natalie Zahan Evans
Nick A Maskell
Abstract
© ERS 2015. Pleural infection is increasing in incidence. Despite optimal medical management, up to 30% of patients will die or require surgery. Case reports suggest that irrigation of the pleural space with saline may be beneficial. A randomised controlled pilot study in which saline pleural irrigation (three times per day for 3 days) plus best-practice management was compared with best-practice management alone was performed in patients with pleural infection requiring chest-tube drainage. The primary outcome was percentage change in computed tomography pleural fluid volume from day 0 to day 3. Secondary outcomes included surgical referral rate, hospital stay and adverse events. 35 patients were randomised. Patients receiving saline irrigation had a significantly greater reduction in pleural collection volume on computed tomography compared to those receiving standard care (median (interquartile range) 32.3% (19.6-43.7%) reduction versus 15.3% (-5.5-28%) reduction) ( p
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2015 |
Journal | European Respiratory Journal |
Print ISSN | 0903-1936 |
Electronic ISSN | 1399-3003 |
Publisher | European Respiratory Society |
Peer Reviewed | Peer Reviewed |
Volume | 46 |
Issue | 2 |
Pages | 456-463 |
DOI | https://doi.org/10.1183/09031936.00147214 |
Keywords | PIT trial, saline irrigation, pleural infection |
Public URL | https://uwe-repository.worktribe.com/output/830191 |
Publisher URL | http://dx.doi.org/10.1183/09031936.00147214 |
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