Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article
Manley, R., Fitch, C., Francis, V., Temperton, I., Turner, D., Fletcher, J., …Temperton, B. (2024). Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii. Journal of Medical Microbiology, 73(5), Article 001829. https://doi.org/10.1099/jmm.0.001829

Introduction . Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons (2024)
Journal Article
Bridge, L., Chen, S., & Jones, B. (2024). Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons. Cellular Signalling, 119, Article 111153. https://doi.org/10.1016/j.cellsig.2024.111153

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway... Read More about Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy (2024)
Journal Article
Manohar, P., Loh, B., Turner, D., Tamizhselvi, R., Mathankumar, M., Elangovan, N., …Leptihn, S. (2024). In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Frontiers in Microbiology, 15, Article 1344962. https://doi.org/10.3389/fmicb.2024.1344962

Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseu... Read More about In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy.