The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom) (2023)
Journal Article
Hotton, E. J., Hotton, E. J., Bale, N., Rose, C., White, P., Wade, J., …Reading, I. (2024). The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom). American Journal of Obstetrics and Gynecology, 230(3), https://doi.org/10.1016/j.ajog.2023.05.018

Background: Decreasing rates of assisted vaginal birth have been paralleled with increasing rates of cesarean deliveries over the last 40 years. The OdonAssist is a novel device for assisted vaginal birth. Iterative changes to clinical parameters, de... Read More about The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom).

A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization (2023)
Journal Article
Beringer, R., Keith, A., Jones, E., Murphy, T., & White, P. (in press). A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization. Pediatric Anesthesia, 33(10), 816-822. https://doi.org/10.1111/pan.14723

Background: Blood pressure measurement is a standard of monitoring during general anesthesia. Invasive measurement is considered the gold standard but is less commonly used than non-invasive. Automated oscillometric blood pressure devices measure the... Read More about A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization.

Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort (2023)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Cerutti, J., Fisher, J., Melton, P., …Dunn, E. C. (2023). Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort. Lancet Child and Adolescent Health, 7(8), 532-543. https://doi.org/10.1016/S2352-4642%2823%2900127-X

Background: Childhood adversity is a potent determinant of health across development and is associated with altered DNA methylation signatures, which might be more common in children exposed during sensitive periods in development. However, it remain... Read More about Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort.

Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study (2023)
Journal Article
Thomas, M., Hayes, K., White, P., Ramesh, A., Culliford, L., Ackland, G., & Pickering, A. (2024). Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study. Neurocritical Care, 40, 795–806. https://doi.org/10.1007/s12028-023-01755-9

Traumatic brain injury is a leading cause of death and disability worldwide. Interventions that mitigate secondary brain injury have the potential to improve outcomes for patients and reduce the impact on communities and society. Increased circulatin... Read More about Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study.

The just-about-right pilot sample size to control the error margin (2023)
Journal Article
Obodo, S., Toher, D., & White, P. (2023). The just-about-right pilot sample size to control the error margin. International Journal of Statistics and Probability, 12(3), https://doi.org/10.5539/ijsp.v12n3p1

In practice, the required sample size for a two-arm randomised controlled trial cannot always be determined pre-study with great accuracy. This lack of accuracy has economic, ethical and scientific implications. The sample size for a pilot study is... Read More about The just-about-right pilot sample size to control the error margin.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article
Harland, A. J., Perks, C. M., White, P., Kurian, K. M., & Barber, H. R. (2023). Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Cancer Medicine, 12(13), 14426-14439. https://doi.org/10.1002/cam4.6071

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs (2023)
Journal Article
Hesketh, E., White, P., Simkiss, D., & Roulstone, S. (2023). Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs. International Journal of Language and Communication Disorders, 58(5), 1510-1525. https://doi.org/10.1111/1460-6984.12877

Abstract Background Understanding the natural history of developmental speech and language impairments can support the selection of children whose difficulties are persistent rather than transitory. It can also provide information against which... Read More about Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs.

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol (2023)
Journal Article
Drabinska, N., Romaszko, J., & White, P. (2023). The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol. PLoS ONE, 18(5), Article e0285283. https://doi.org/10.1371/journal.pone.0285283

Obesity is considered one of the biggest health problems of the 21st century, becoming a worldwide epidemic, leading to the development of many diseases and increasing the risk of premature death. The first step in reducing body weight is a calorie-r... Read More about The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol.

The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial (2023)
Journal Article
Sundaralingam, A., Hedley, E., Tucker, E., White, P., Bhatnagar, R., Moore, A., …Maskell, N. A. (2023). The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial. BMJ Open Respiratory Research, 10(1), e001682. https://doi.org/10.1136/bmjresp-2023-001682

INTRODUCTION: Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and optimising... Read More about The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article
Grätz, L., Sajkowska-Kozielewicz, J. J., Wesslowski, J., Kinsolving, J., Bridge, L. J., Petzold, K., …Kozielewicz, P. (in press). NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model. British Journal of Pharmacology, https://doi.org/10.1111/bph.16090

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort (2023)
Journal Article
Johnson, L., White, P., Holcombe, C., O’Donoghue, J., Jeevan, R., Browne, J., …O'Donoghue, J. (2023). Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort. British Journal of Surgery, 110(6), 666-675. https://doi.org/10.1093/bjs/znad050

Background: Women considering immediate breast reconstruction require high-quality information about the likely need for secondary reconstruction and the long-term risk of revisional surgery to make fully informed decisions about different reconstruc... Read More about Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort.

Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration (2023)
Journal Article
Williams, R. L., Hyams, C., Robertshaw, J., Garcia Gonzalez, M., Szasz-Benczur, Z., White, P., … Barratt, S. L. (2023). Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration. Respiratory Medicine, 212, 107220. https://doi.org/10.1016/j.rmed.2023.107220

Introduction: Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scor... Read More about Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration.

Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence (2023)
Journal Article
Dunn, E. C., Busso, D. S., Davis, K. A., Smith, A. D. A. C., Mitchell, C., Tiemeier, H., & Susser, E. S. (2023). Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence. Complex Psychiatry, 9(1-4), 145-153. https://doi.org/10.1159/000530120

Introduction: Child maltreatment is among the strongest risk factors for mental disorders. However, little is known about whether there are ages when children may be especially vulnerable to its effects. We sought to identify potential sensitive peri... Read More about Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence.

Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions (2023)
Journal Article
Sikurajapathi, B., Henderson, K., & Gwynllyw, R. (2023). Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions. MSOR Connections, 21(Special Issue: CETL-MSOR Conference 2022 Part 1), 43-51. https://doi.org/10.21100/msor.v21i1

Students may arrive at an incorrect answer when answering a mathematical question due to several reasons, such as random errors, calculation errors or misreading the question. Such errors are sometimes referred to as Common Student Errors (CSEs). Thi... Read More about Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions.

Predictive models in emergency medicine and their missing data strategies: a systematic review (2023)
Journal Article
Arnaud, E., Elbattah, M., Ammirati, C., Dequen, G., & Ghazali, D. A. (2023). Predictive models in emergency medicine and their missing data strategies: a systematic review. npj Digital Medicine, 6(1), 28. https://doi.org/10.1038/s41746-023-00770-6

In the field of emergency medicine (EM), the use of decision support tools based on artificial intelligence has increased markedly in recent years. In some cases, data are omitted deliberately and thus constitute “data not purposely collected” (DNPC)... Read More about Predictive models in emergency medicine and their missing data strategies: a systematic review.

The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2023)
Journal Article
Challapalli, A., White, P., Masson, S., Foulstone, E., Renninson, E., Bravo, A., …Bahl, A. (2023). The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder. Journal of Clinical Oncology, 41(6_suppl), 493-493. https://doi.org/10.1200/JCO.2023.41.6_suppl.493

Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) improves survival in muscle invasive bladder cancer (MIBC). However, response rates and survival remain suboptimal. We sought to evaluate the efficacy of cabazitaxel with cisplati... Read More about The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide (2023)
Journal Article
Challapali, A., Rennison, E., White, P., Elumalai, T., Parikh, O., Vickers, A., …Bahl, A. (2023). Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide. Journal of Clinical Oncology, 41(6_suppl), 335. https://doi.org/10.1200/JCO.2023.41.6_suppl.335

Background: The RECORD Study is a real world data, prospective evaluation of clinical outcomes in patients with nmCRPC treated with Darolutamide. This study will increase the understanding of treatment response and management and in particular inform... Read More about Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide.

Applications of machine learning methods to assist the diagnosis of autism spectrum disorder (2023)
Book Chapter
Elbattah, M., Carette, R., Cilia, F., Guérin, J., & Dequen, G. (2023). Applications of machine learning methods to assist the diagnosis of autism spectrum disorder. In Neural Engineering Techniques for Autism Spectrum Disorder, Volume 2: Diagnosis and Clinical Analysis (99-119). Elsevier. https://doi.org/10.1016/B978-0-12-824421-0.00013-8

Autism spectrum disorder (ASD) is a lifelong neuro-developmental disorder that is generally marked by a set of communication and social impairments. The early diagnosis of autism is genuinely beneficial for the welfare of children and parents as well... Read More about Applications of machine learning methods to assist the diagnosis of autism spectrum disorder.

Review of the partially overlapping samples framework: Paired observations and independent observations in two samples (2022)
Journal Article
Derrick, B., & White, P. (2022). Review of the partially overlapping samples framework: Paired observations and independent observations in two samples. Quantitative Methods for Psychology, 18(1), 55-65. https://doi.org/10.20982/tqmp.18.1.p055

A frequently asked question in quantitative research is how to compare two samples that include some combination of paired observations and unpaired observations. In our publications and R package, we refer to the scenario as ‘partially overlapping... Read More about Review of the partially overlapping samples framework: Paired observations and independent observations in two samples.

Vision-based approach for autism diagnosis using transfer learning and eye-tracking (2022)
Conference Proceeding
Elbattah, M., Guérin, J., Carette, R., Cilia, F., & Dequen, G. (2022). Vision-based approach for autism diagnosis using transfer learning and eye-tracking. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies - HEALTHINF (256-263). https://doi.org/10.5220/0010975500003123

The potentials of Transfer Learning (TL) have been well-researched in areas such as Computer Vision and Natural Language Processing. This study aims to explore a novel application of TL to detect Autism Spectrum Disorder. We seek to develop an approa... Read More about Vision-based approach for autism diagnosis using transfer learning and eye-tracking.