Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study (2024)
Journal Article
Davies, C., Conefrey, C., Mills, N., Fairbrother, P., Holcombe, C., Whisker, L., …Potter, S. (in press). Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study. British Journal of Surgery,

ABSTRACT Background: Oncoplastic breast conserving surgery (OPBCS) may allow women with early breast cancer to avoid mastectomy, but many women choose more extensive surgery even when breast conserving options are offered. Reasons for this are un... Read More about Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study.

Changes in attitudes towards telemedicine in acute burn care following the Covid-19 pandemic   (2024)
Journal Article
Goh, E., Press, I., Anquandah, J., White, P., & Pleat, J. (in press). Changes in attitudes towards telemedicine in acute burn care following the Covid-19 pandemic  . Burns,

Background Telemedical referrals after burn injury had been shown to be advantageous over telephone referrals for multiple reasons, however there were several key barriers towards complete implementation. The Covid-19 pandemic facilitated the adopt... Read More about Changes in attitudes towards telemedicine in acute burn care following the Covid-19 pandemic  .

The inadvertently revealing statistic: A systemic gap in statistical training? (2024)
Journal Article
Derrick, B., Green, E., Ritchie, F., Smith, J., & White, P. (2024). The inadvertently revealing statistic: A systemic gap in statistical training?. Significance, 21(1), 24-27. https://doi.org/10.1093/jrssig/qmae009

While concerns around data privacy are well-known, there's a lack of awareness and training when it comes to the confidentiality risk of published statistics, argue Ben Derrick, Elizabeth Green, Felix Ritchie, Jim Smith, Paul White

The incidence of physician-diagnosed food allergy declines with age: A specialist UK centre experience (2023)
Journal Article
Grammatikos, A., Moghaddas, F., White, P., Fox, C., Johnston, S., Tsiougkos, N., & Gompels, M. (2024). The incidence of physician-diagnosed food allergy declines with age: A specialist UK centre experience. Clinical and Experimental Allergy, 54(2), 143-144. https://doi.org/10.1111/cea.14405

The incidence of physician-diagnosed food allergy declined with age in a cohort of UK adults. Men were more likely to be diagnosed with food allergy than women. The incidence of shellfish, wheat & cereals and vegetable & herb allergies increase... Read More about The incidence of physician-diagnosed food allergy declines with age: A specialist UK centre experience.

Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study (2023)
Journal Article
Johnson, L., White, P., Jeevan, R., Browne, J., Gulliver-Clarke, C., O’Donoghue, J., …Potter, S. (2023). Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study. British Journal of Surgery, 110(12), 1815-1823. https://doi.org/10.1093/bjs/znad276

BACKGROUND: Breast reconstruction is offered to improve quality of life for women after mastectomy for breast cancer, but information regarding the long-term patient-reported outcomes of different reconstruction procedures is currently lacking. The B... Read More about Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study.

The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom) (2023)
Journal Article
Hotton, E. J., Hotton, E. J., Bale, N., Rose, C., White, P., Wade, J., …Reading, I. (2024). The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom). American Journal of Obstetrics and Gynecology, 230(3), https://doi.org/10.1016/j.ajog.2023.05.018

Background: Decreasing rates of assisted vaginal birth have been paralleled with increasing rates of cesarean deliveries over the last 40 years. The OdonAssist is a novel device for assisted vaginal birth. Iterative changes to clinical parameters, de... Read More about The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom).

A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization (2023)
Journal Article
Beringer, R., Keith, A., Jones, E., Murphy, T., & White, P. (in press). A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization. Pediatric Anesthesia, 33(10), 816-822. https://doi.org/10.1111/pan.14723

Background: Blood pressure measurement is a standard of monitoring during general anesthesia. Invasive measurement is considered the gold standard but is less commonly used than non-invasive. Automated oscillometric blood pressure devices measure the... Read More about A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization.

Oncological outcomes after transanal total mesorectal excision for rectal cancer (2023)
Journal Article
Francis, N., Penna, M., Dritsas, S., Kinsey, H., Moran, B., Nicol, D., …Wynn, G. (2023). Oncological outcomes after transanal total mesorectal excision for rectal cancer. British Journal of Surgery, 110(12), 1614-1617. https://doi.org/10.1093/bjs/znad168

Transanal total mesorectal excision (TaTME) was developed to overcome the technical difficulties of a transabdominal minimal-access approach to resection of low rectal cancer1–4. TaTME was reported to be feasible and effective, with the potential adv... Read More about Oncological outcomes after transanal total mesorectal excision for rectal cancer.

Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study (2023)
Journal Article
Thomas, M., Hayes, K., White, P., Ramesh, A., Culliford, L., Ackland, G., & Pickering, A. (2024). Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study. Neurocritical Care, 40, 795–806. https://doi.org/10.1007/s12028-023-01755-9

Traumatic brain injury is a leading cause of death and disability worldwide. Interventions that mitigate secondary brain injury have the potential to improve outcomes for patients and reduce the impact on communities and society. Increased circulatin... Read More about Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study.

The just-about-right pilot sample size to control the error margin (2023)
Journal Article
Obodo, S., Toher, D., & White, P. (2023). The just-about-right pilot sample size to control the error margin. International Journal of Statistics and Probability, 12(3), https://doi.org/10.5539/ijsp.v12n3p1

In practice, the required sample size for a two-arm randomised controlled trial cannot always be determined pre-study with great accuracy. This lack of accuracy has economic, ethical and scientific implications. The sample size for a pilot study is... Read More about The just-about-right pilot sample size to control the error margin.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article
Harland, A. J., Perks, C. M., White, P., Kurian, K. M., & Barber, H. R. (2023). Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Cancer Medicine, 12(13), 14426-14439. https://doi.org/10.1002/cam4.6071

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs (2023)
Journal Article
Hesketh, E., White, P., Simkiss, D., & Roulstone, S. (2023). Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs. International Journal of Language and Communication Disorders, 58(5), 1510-1525. https://doi.org/10.1111/1460-6984.12877

Abstract Background Understanding the natural history of developmental speech and language impairments can support the selection of children whose difficulties are persistent rather than transitory. It can also provide information against which... Read More about Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs.

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol (2023)
Journal Article
Drabinska, N., Romaszko, J., & White, P. (2023). The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol. PLoS ONE, 18(5), Article e0285283. https://doi.org/10.1371/journal.pone.0285283

Obesity is considered one of the biggest health problems of the 21st century, becoming a worldwide epidemic, leading to the development of many diseases and increasing the risk of premature death. The first step in reducing body weight is a calorie-r... Read More about The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol.

The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial (2023)
Journal Article
Sundaralingam, A., Hedley, E., Tucker, E., White, P., Bhatnagar, R., Moore, A., …Maskell, N. A. (2023). The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial. BMJ Open Respiratory Research, 10(1), e001682. https://doi.org/10.1136/bmjresp-2023-001682

INTRODUCTION: Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and optimising... Read More about The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial.

Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort (2023)
Journal Article
Johnson, L., White, P., Holcombe, C., O’Donoghue, J., Jeevan, R., Browne, J., …O'Donoghue, J. (2023). Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort. British Journal of Surgery, 110(6), 666-675. https://doi.org/10.1093/bjs/znad050

Background: Women considering immediate breast reconstruction require high-quality information about the likely need for secondary reconstruction and the long-term risk of revisional surgery to make fully informed decisions about different reconstruc... Read More about Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort.

Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration (2023)
Journal Article
Williams, R. L., Hyams, C., Robertshaw, J., Garcia Gonzalez, M., Szasz-Benczur, Z., White, P., … Barratt, S. L. (2023). Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration. Respiratory Medicine, 212, 107220. https://doi.org/10.1016/j.rmed.2023.107220

Introduction: Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scor... Read More about Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration.

The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2023)
Journal Article
Challapalli, A., White, P., Masson, S., Foulstone, E., Renninson, E., Bravo, A., …Bahl, A. (2023). The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder. Journal of Clinical Oncology, 41(6_suppl), 493-493. https://doi.org/10.1200/JCO.2023.41.6_suppl.493

Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) improves survival in muscle invasive bladder cancer (MIBC). However, response rates and survival remain suboptimal. We sought to evaluate the efficacy of cabazitaxel with cisplati... Read More about The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide (2023)
Journal Article
Challapali, A., Rennison, E., White, P., Elumalai, T., Parikh, O., Vickers, A., …Bahl, A. (2023). Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide. Journal of Clinical Oncology, 41(6_suppl), 335. https://doi.org/10.1200/JCO.2023.41.6_suppl.335

Background: The RECORD Study is a real world data, prospective evaluation of clinical outcomes in patients with nmCRPC treated with Darolutamide. This study will increase the understanding of treatment response and management and in particular inform... Read More about Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide.

Review of the partially overlapping samples framework: Paired observations and independent observations in two samples (2022)
Journal Article
Derrick, B., & White, P. (2022). Review of the partially overlapping samples framework: Paired observations and independent observations in two samples. Quantitative Methods for Psychology, 18(1), 55-65. https://doi.org/10.20982/tqmp.18.1.p055

A frequently asked question in quantitative research is how to compare two samples that include some combination of paired observations and unpaired observations. In our publications and R package, we refer to the scenario as ‘partially overlapping... Read More about Review of the partially overlapping samples framework: Paired observations and independent observations in two samples.

BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam (2022)
Journal Article
Naddell, S., Manuel, M., Cavill, R., White, P., & Sieradzan, K. (2023). BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam. Epilepsy and Behavior, 138, 108985. https://doi.org/10.1016/j.yebeh.2022.108985

Objective: Via measures of efficacy, tolerability, and safety, this open-label, single-center study assessed the overall effectiveness of Brivaracetam (BRV) for the treatment of epilepsy in the context of ‘real-world’ clinical practice. Methods: Unse... Read More about BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam.