Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine? (2024)
Journal Article
Smith, A. D., Newton, J., & Smith, A. (2024). Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine?. BMC Medical Education, 24(1), Article 544. https://doi.org/10.1186/s12909-024-05526-8

Background: Clinical acumen represents only part of being adequately equipped to attend a major incident. The emotive sights, sounds and smells of these dynamic environments are all-encompassing experiences, and responders must also be armed with the... Read More about Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine?.

How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey (2024)
Journal Article
Le Luyer, M., Boll, M., Lemmers, S., Stoll, S., Hoffnagle, A., Smith, A., & Dunn, E. (in press). How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey. Community Dentistry and Oral Epidemiology, https://doi.org/10.1111/cdoe.12971

Objectives: Naturally exfoliated primary teeth are being increasingly collected in child development studies. Most of these odontological collections and tooth biobanks use parent-reported information from questionnaires or tooth checklists to collec... Read More about How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey.

The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts (2024)
Journal Article
Farooq, B., Russell, A., Howe, L., Herbert, A., Smith, A., Fisher, H., …Mars, B. (in press). The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.13986

Background: Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure t... Read More about The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts.

Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis (2024)
Journal Article
López-López, J., Tilling, K., Pearson, R., Fazel, M., Washbrook, E., Zhu, Y., …Smith, A. (in press). Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis. Psychological Medicine,

Depression is a common mental health disorder which often starts during adolescence, with potentially important future consequences including ‘Not in Education, Employment or Training’ (NEET) status. In this study, we took a structured life course mo... Read More about Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis.

Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort (2023)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Cerutti, J., Fisher, J., Melton, P., …Dunn, E. C. (2023). Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort. Lancet Child and Adolescent Health, 7(8), 532-543. https://doi.org/10.1016/S2352-4642%2823%2900127-X

Background: Childhood adversity is a potent determinant of health across development and is associated with altered DNA methylation signatures, which might be more common in children exposed during sensitive periods in development. However, it remain... Read More about Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort.

Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence (2023)
Journal Article
Dunn, E. C., Busso, D. S., Davis, K. A., Smith, A. D. A. C., Mitchell, C., Tiemeier, H., & Susser, E. S. (2023). Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence. Complex Psychiatry, 9(1-4), 145-153. https://doi.org/10.1159/000530120

Introduction: Child maltreatment is among the strongest risk factors for mental disorders. However, little is known about whether there are ages when children may be especially vulnerable to its effects. We sought to identify potential sensitive peri... Read More about Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence.

Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children (2022)
Journal Article
Lacey, R. E., Gondek, D., Smith, B. J., Smith, A. D., Dunn, E. C., & Sacker, A. (2023). Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children. Journal of Child Psychology and Psychiatry, 64(8), 1149-1158. https://doi.org/10.1111/jcpp.13699

Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when bes... Read More about Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children.

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach (2022)
Journal Article
Zhu, Y., Lussier, A. A., Smith, A. D. A. C., Simpkin, A. J., Suderman, M. J., Walton, E., …Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach. Psychoneuroendocrinology, 144(October 2022), 105854. https://doi.org/10.1016/j.psyneuen.2022.105854

Background: Sensitive periods are developmental stages of heightened plasticity when life experiences, including exposure to childhood adversity, have the potential to exert more lasting impacts. Epigenetic mechanisms, including DNA methylation (DNAm... Read More about Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach.

Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study (2022)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Simpkin, A. J., Smith, A. D. A. C., Suderman, M. J., …Dunn, E. C. (2023). Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study. Biological Psychiatry: Global Open Science, 3(3), 567-571. https://doi.org/10.1016/j.bpsgos.2022.04.002

Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA) (2022)
Book Chapter
Smith, B. J., Smith, A. D., & Dunn, E. C. (2022). Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA). In Sensitive Periods of Brain Development and Preventive Interventions (215-234). Springer. https://doi.org/10.1007/7854_2021_280

Sensitive periods are times during development when life experiences can have a greater impact on outcomes than at other periods during the life course. However, a dearth of sophisticated methods for studying time-dependent exposure-outcome relations... Read More about Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA).

Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study (2022)
Journal Article
Dunn, E. C., Mountain, R. V., Davis, K. A., Shaffer, I., Smith, A. D. A. C., Roubinov, D. S., …Boyce, W. T. (2022). Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study. Frontiers in Dental Medicine, 3, Article 803364. https://doi.org/10.3389/fdmed.2022.803364

Mental disorders are among the most disabling health conditions globally. However, there remains a lack of valid, reliable, noninvasive, and inexpensive biomarkers to identify (at an early age) people who are at the greatest risk of experiencing a fu... Read More about Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study.

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies (2022)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Simpkin, A. J., Smith, A. D., Suderman, M. J., …Dunn, E. C. (2022). Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies. Epigenetics, https://doi.org/10.1080/15592294.2022.2028072

Introduction: Biomedical research has grown increasingly cooperative through the sharing of consortia-level epigenetic data. Since consortia preprocess data prior to distribution, new processing pipelines can lead to different versions of the same d... Read More about Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies.

2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births (2021)
Journal Article
Gromski, P. S., Smith, A. D., Lawlor, D. A., Sharara, F. I., & Nelson, S. M. (2021). 2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births. Reproductive BioMedicine Online, 42(6), 1087-1096. https://doi.org/10.1016/j.rbmo.2021.03.017

Research question The economic and reproductive medicine response to the coronavirus disease 2019 (COVID-19) pandemic in the USA has reduced the affordability and accessibility of fertility care. What is the impact of the 2008 financial recession an... Read More about 2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births.

A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context (2020)
Journal Article
Zhu, Y., Simpkin, A. J., Suderman, M. J., Lussier, A. A., Walton, E., Dunn, E. C., & Smith, A. D. A. C. (2021). A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context. American Journal of Epidemiology, 190(6), 1101-1112. https://doi.org/10.1093/aje/kwaa246

The structured life course modeling approach (SLCMA) is a theory-driven analytic method that empirically compares multiple prespecified life course hypotheses characterizing time-dependent exposure-outcome relationships to determine which theory best... Read More about A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context.

Exposure to early childhood maltreatment and its effect over time on social cognition (2020)
Journal Article
Crawford, K. M., Choi, K., Davis, K. A., Zhu, Y., Soare, T. W., Smith, A. D., …Dunn, E. C. (2022). Exposure to early childhood maltreatment and its effect over time on social cognition. Development and Psychopathology, 34(1), 409 - 419. https://doi.org/10.1017/s095457942000139x

Social cognitive deficits can have many negative consequences, spanning social withdrawal to psychopathology. Prior work has shown that child maltreatment may associate with poorer social cognitive skills in later life. However, no studies have exami... Read More about Exposure to early childhood maltreatment and its effect over time on social cognition.