Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article
Pisignano, G., Michael, D. C., Pirlog, R., Visal, T. H., Ladomery, M., & Calin, G. A. (in press). Going circular: history, present, and future of circRNAs in cancer. Oncogene, 10.1038/s41388-023-02780-w. https://doi.org/10.1038/s41388-023-02780-w

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease (2023)
Thesis
Usmari Moraes, M. Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10013675

Introduction: Oxidative stress and impaired homeostasis are key features of type 2 diabetes mellitus, which is comorbid with Alzheimer’s disease. Dysregulation of the branched-chain aminotransferase protein, which is overexpressed in AD, is suggested... Read More about Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease.

Dual wavelength retinal vessel oximetry – influence of fundus pigmentation (2022)
Journal Article
Hirsch, K., Cubbidge, R. P., & Heitmar, R. (2023). Dual wavelength retinal vessel oximetry – influence of fundus pigmentation. Eye, 37(11), 2246-2251. https://doi.org/10.1038/s41433-022-02325-7

Background: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturati... Read More about Dual wavelength retinal vessel oximetry – influence of fundus pigmentation.

Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia (2022)
Journal Article
Chung, A. M., Love, E., Neidel, J., Mendai, I., Nairenge, S., van Wyk, L. A., …Gosling, R. (2022). Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia. American Journal of Tropical Medicine and Hygiene, 106(6), 1646-1652. https://doi.org/10.4269/ajtmh.21-1195

Leadership and management skills are critical for health programs to deliver high-quality interventions in complex systems. In malaria-eliminating countries, national and subnational health teams are reorienting strategies to address focal transmissi... Read More about Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia.

Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea (2022)
Journal Article
Branch, D., Moka Sharpe, S., Maho, L. M., Silochi Pons, M. Á., Mitogo Michá, F., Motove Etingüe, A., …Fernández, D. (2022). Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea. Frontiers in Conservation Science, 3, Article 780162. https://doi.org/10.3389/fcosc.2022.780162

Bioko is one of the most important sites for African primate conservation; yet it has seen a severe decline in its primate populations due to illegal hunting to supply a thriving wildmeat trade. The completion in 2015 of a new road bisecting the Gran... Read More about Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea.

An on-premise study to investigate the effects of mixing alcohol with caffeinated beverages (2022)
Journal Article
Johnson, S. J., Verster, J. C., & Alford, C. (2022). An on-premise study to investigate the effects of mixing alcohol with caffeinated beverages. Brain and Behavior, 12(3), Article e2445. https://doi.org/10.1002/brb3.2445

Objective: The purpose of this on-premise study was to determine if mixing alcohol with caffeinated mixers had an impact on objective and subjective intoxication. Methods: The study was conducted across eight drinking occasions in the City of Bristol... Read More about An on-premise study to investigate the effects of mixing alcohol with caffeinated beverages.

Automatic report-based labelling of clinical EEGs for classifier training (2022)
Conference Proceeding
Western, D., Weber, T., Kandasamy, R., May, F., Taylor, S., Zhu, Y., & Canham, L. (2022). Automatic report-based labelling of clinical EEGs for classifier training. In 2021 IEEE Signal Processing in Medicine and Biology Symposium (SPMB). https://doi.org/10.1109/SPMB52430.2021.9672295

Machine learning classifiers for detection of abnormal clinical electroencephalography (EEG) signals have advanced signficantly in recent years, largely supported by the carefully curated Temple University Hospital Abnormal EEG Corpus (TUAB). Further... Read More about Automatic report-based labelling of clinical EEGs for classifier training.

A comparison between ecological momentary assessment and the adapted-quick drinking screen: Alcohol mixed with energy drinks (2022)
Journal Article
Johnson, S. J., Verster, J. C., & Alford, C. (2022). A comparison between ecological momentary assessment and the adapted-quick drinking screen: Alcohol mixed with energy drinks. Alcohol and Alcoholism, 57(5), 630-640. https://doi.org/10.1093/alcalc/agab086

AIMS: To compare alcohol consumption and risk-taking behaviours on alcohol mixed with energy drink (AMED) and alcohol-only (AO) drinking occasions collected via ecological momentary assessment (EMA) versus retrospective survey methods (adapted-Quick... Read More about A comparison between ecological momentary assessment and the adapted-quick drinking screen: Alcohol mixed with energy drinks.

An analysis of the NHS Cord Blood Bank; Barriers to cord blood donation and quality parameters limiting storage (2022)
Thesis
Ross, A. An analysis of the NHS Cord Blood Bank; Barriers to cord blood donation and quality parameters limiting storage. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6873528

The NHS Cord Bank was established in 1996 to build an inventory of altruistically donated cord blood units to provide equity of access to all patients eligible for a stem cell transplant. Fixed cord blood collection sites were selected in areas of hi... Read More about An analysis of the NHS Cord Blood Bank; Barriers to cord blood donation and quality parameters limiting storage.

Accelerometers-embedded Lycra sleeves to test wear compliance and upper limb activity in people with stroke: A feasibility study (2021)
Journal Article
Kumar, P., Brodie, S., Molton, J., O'Reilly, R., Steele, J., Pearce, A., …Caleb-Solly, P. (2023). Accelerometers-embedded Lycra sleeves to test wear compliance and upper limb activity in people with stroke: A feasibility study. Journal of Prosthetics and Orthotics, 35(2), 122-128. https://doi.org/10.1097/JPO.0000000000000406

Introduction To establish a possible effect of Lycra sleeves, accurate recording of wear time is critical. The aim of this study was to test whether an accelerometer-embedded Lycra sleeve can measure wear compliance and record upper-limb (UL) movemen... Read More about Accelerometers-embedded Lycra sleeves to test wear compliance and upper limb activity in people with stroke: A feasibility study.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G., Wexler, S. A., Upstill-Goddard, G., Cox, C., & May, J. E. (2021). Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected. Mutagenesis, 36(6), 419-428. https://doi.org/10.1093/mutage/geab033

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.

How do illness perceptions influence the effectiveness of self-management in individuals living in Bermuda with type 2 diabetes? (2021)
Thesis
Matthew, T. How do illness perceptions influence the effectiveness of self-management in individuals living in Bermuda with type 2 diabetes?. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7212112

Diabetes is a chronic condition that occurs when blood glucose, or blood sugar, levels are too high in the body (NHS, 2016). Diabetes UK (2009) estimates that self-management is 95% of managing diabetes. Self-management refers to an individual’s abil... Read More about How do illness perceptions influence the effectiveness of self-management in individuals living in Bermuda with type 2 diabetes?.

Data-driven approach to COVID-19 infection forecast for Nigeria using negative binomial regression model (2021)
Book Chapter
Olisah, C. C., Ilori, O. O., Adelaja, K., Usip, P. U., Uzoechi, L. O., Adeyanju, I. A., & Odumuyiwa, V. T. (2021). Data-driven approach to COVID-19 infection forecast for Nigeria using negative binomial regression model. In Data Science for COVID-19 (583-596). Elsevier. https://doi.org/10.1016/b978-0-12-824536-1.00002-2

COVID-19: the new wave of a global pandemic, is bringing about an increasing number of scientific efforts aimed at enabling governments to make informed decisions. In this paper, we explore the negative binomial regression model from the family of ge... Read More about Data-driven approach to COVID-19 infection forecast for Nigeria using negative binomial regression model.

Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Lafargue, P. Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6642792

Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Porazinski, S., Li, L., Clark, B., Ajiro, M., Iida, K., …Ladomery, M. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), Article 7963. https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomized trial (2021)
Journal Article
Lewis, J. S., Newport, R., Taylor, G., Smith, M., & McCabe, C. S. (2021). Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomized trial. European Journal of Pain, 25(7), 1551-1563. https://doi.org/10.1002/ejp.1766

Background: Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence of pain re... Read More about Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomized trial.

Patient reported outcomes in large vessel vasculitides (2021)
Journal Article
Robson, J., Mackie, S., & Hill, C. (2021). Patient reported outcomes in large vessel vasculitides. Current Rheumatology Reports, 23(2), Article 7. https://doi.org/10.1007/s11926-020-00979-4

Purpose of Review: The goal of this paper is to review current and future uses of patient-reported outcomes in large vessel vasculitis. The large vessel vasculitides comprise Giant Cell Arteritis and Takayasu arteritis; both are types of systemic vas... Read More about Patient reported outcomes in large vessel vasculitides.

Sleep disorders among undergraduate health students in Bristol, United Kingdom (2020)
Journal Article
Zafar, M., & Ansari, K. (2020). Sleep disorders among undergraduate health students in Bristol, United Kingdom. Mediterranean Journal of Clinical Psychology, 8(3), 1-15. https://doi.org/10.6092/2282-1619/mjcp-2494

Daytime Sleepiness and poor sleep quality are common among medical students. The objective of study is to determine the prevalence of daytime sleepiness and sleep quality and associated risk factors among medical students in medical college, in Brist... Read More about Sleep disorders among undergraduate health students in Bristol, United Kingdom.

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer (2020)
Journal Article
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., …Relton, C. L. (2021). A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention, 30(3), 564-575. https://doi.org/10.1158/1055-9965.EPI-20-1176

Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new... Read More about A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer.