Skip to main content

Research Repository

Advanced Search

Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Lafargue, P. Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6642792

Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Oltean, S., Ladomery, M., Alqasem, A., Perks, C., Wilson, I. D., …Iida, K. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article
Belali, T., Wodi, C., Clark, B., Cheung, M. K., Craig, T. J., Wheway, G., …Ladomery, M. (2020). WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1. BBA - Gene Regulatory Mechanisms, 1863(12), https://doi.org/10.1016/j.bbagrm.2020.194642

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment (2020)
Thesis
Okeke, K. Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/2812709

Modern chemotherapeutic regimens for adult and childhood leukaemia rely on the use of a combination of various cytotoxic agents. Unfortunately, haematopoietic stem cell transplant, a last resort treatment for haematologic malignancies requires high d... Read More about Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment.

APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps (2020)
Journal Article
Almond, S., Anaraki, F., Young, C., Ashrafian Bonab, M., Asadzadeh-Aghdaei, H., Rezvani, H., …Ladomery, M. (2020). APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps. Cancer Informatics, 19, 1-8. https://doi.org/10.1177/1176935120972383

Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and hyper... Read More about APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps.

Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis (2019)
Journal Article
Akpiri, R. U., Hodges, N. J., & Konya, R. S. (2020). Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis. Journal of Marine Science, 2(1), https://doi.org/10.30564/jms.v2i1.1070

Aluminium is the most abundant element in the earth crust, and has no known biological function. However, it is an established neurotoxicant in its trivalent oxidation state, with exposure resulting in neurodegenerative diseases like Parkinson’s dise... Read More about Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis.

Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease (2019)
Journal Article
May, J., Gynn, L., Anderson, E., & Robinson, G. (2019). Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease. Mutagenesis, 34(5/6), e5. https://doi.org/10.1093/mutage/gez025

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease.

Prevalence of Carbapenemase Producing Organisms in East London, UK. (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., & Nelson, S. (2019, September). Prevalence of Carbapenemase Producing Organisms in East London, UK. Poster presented at IBMS Congress 2019, Birmingham

Carbapenemases are enzymes, produced by an array of common Gram-negative organisms, which hydrolyse the carbapenem antibiotics, conferring resistance [1]. The main protagonists are the “big five” carbapenemases, KPC, OXA-48, IMP, VIM and NDM, which h... Read More about Prevalence of Carbapenemase Producing Organisms in East London, UK..

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment (2019)
Journal Article
Ladomery, M., Koschorke, A., Faraci, S., Giani, D., Iorio, E., Canese, R., …Chiodoni, C. (2019). Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment. Cellular Oncology, 42(6), 815-828. https://doi.org/10.1007/s13402-019-00464-w

© 2019, International Society for Cellular Oncology. Purpose: Isothiocyanates elicit anticancer effects by targeting cancer stem cells (CSCs). Here, we tested the antitumor activity of phenethyl-isothiocyanate (PEITC), either alone or in combination... Read More about Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.

Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay (2017)
Journal Article
Akpiri, R. U., Konya, R. S., & Hodges, N. J. (2017). Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay. Environmental Toxicology and Chemistry, 36(12), 3314-3323. https://doi.org/10.1002/etc.3907

© 2017 SETAC Sponges are a potential alternative model species to bivalves in pollution biomonitoring and environmental risk assessment in the aquatic ecosystem. In the present study, a novel in vivo exposure sponge culture model was developed from f... Read More about Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay.

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest (2010)
Journal Article
Harley, M. E., Allan, L. A., Sanderson, H. S., & Clarke, P. R. (2010). Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO Journal, 29(14), 2407-2420. https://doi.org/10.1038/emboj.2010.112

The balance between cell cycle progression and apoptosis is important for both surveillance against genomic defects and responses to drugs that arrest the cell cycle. In this report, we show that the level of the human anti-apoptotic protein Mcl-1 is... Read More about Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.