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Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article
Hancock, J. T., & Neill, S. J. (2019). Nitric oxide: Its generation and interactions with other reactive signaling compounds. Plants, 8(2), 41. https://doi.org/10.3390/plants8020041

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

Nitric oxide signalling in plants (2017)
Book Chapter
Hancock, J. T., Wilson, H. R., & Neill, S. (2017). Nitric oxide signalling in plants. In eLS. Chichester: Wiley. https://doi.org/10.1002/9780470015902.a0020109.pub2

Nitric oxide (NO) is a small simple molecule but one which is instrumental in cell signalling in a range of organisms including plants. It is a gas, often found in the form of a radical. It is produced in cells in an orchestrated manner, usually by d... Read More about Nitric oxide signalling in plants.

Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling (2015)
Journal Article
Chater, C., Peng, K., Movahedi, M., Dunn, J. A., Walker, H. J., Liang, Y., …Hetherington, A. M. (2015). Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling. Current Biology, 25(20), 2709-2716. https://doi.org/10.1016/j.cub.2015.09.013

© 2015 The Authors. An integral part of global environment change is an increase in the atmospheric concentration of CO2 ([CO2]) [1]. Increased [CO2] reduces leaf stomatal apertures and density of stomata that plays out as reductions in evapotranspir... Read More about Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling.

Nitric oxide and ABA in the control of plant function (2011)
Journal Article
Hancock, J. T., Neill, S., & Wilson, I. D. (2011). Nitric oxide and ABA in the control of plant function. Plant Science, 181(5), 555-559. https://doi.org/10.1016/j.plantsci.2011.03.017

Abscisic acid (ABA) and nitric oxide (NO) are both extremely important signalling molecules employed by plants to control many aspects of physiology. ABA has been extensively studied in the mechanisms which control stomatal movement as well as in see... Read More about Nitric oxide and ABA in the control of plant function.

Overexpression of OsRAN2 in rice and Arabidopsis renders transgenic plants hypersensitive to salinity and osmotic stress (2010)
Journal Article
Zang, A., Xu, X., Neill, S., & Cai, W. (2010). Overexpression of OsRAN2 in rice and Arabidopsis renders transgenic plants hypersensitive to salinity and osmotic stress. Journal of Experimental Botany, 61(3), 777-789. https://doi.org/10.1093/jxb/erp341

Nucleo-cytoplasmic partitioning of regulatory proteins is increasingly being recognized as a major control mechanism for the regulation of signalling in plants. Ras-related nuclear protein (Ran) GTPase is required for regulating transport of proteins... Read More about Overexpression of OsRAN2 in rice and Arabidopsis renders transgenic plants hypersensitive to salinity and osmotic stress.

Reactive oxygen species, nitric oxide and signal crosstalk (2009)
Book Chapter
Neill, S., Hancock, J. T., & Wilson, I. D. (2009). Reactive oxygen species, nitric oxide and signal crosstalk. In K. Yoshioka, & K. Shinozaki (Eds.), Signal Crosstalk in Plant Stress Responses (136-160). Iowa: Wiley-Blackwell

Fungal elicitor Pep-25 increases cytosolic calcium ions, H 2O2 production and activates the octadecanoid pathway in Arabidopsis thaliana (2009)
Journal Article
Hu, X., Neill, S., Yang, Y., & Cai, W. (2009). Fungal elicitor Pep-25 increases cytosolic calcium ions, H 2O2 production and activates the octadecanoid pathway in Arabidopsis thaliana. Planta, 229(6), 1201-1208. https://doi.org/10.1007/s00425-009-0909-3

Transgenic Arabidopsis thaliana plants expressing the protein aequorin were used to investigate the transient change in cytosolic calcium ions caused by stimulation through the fungal elicitor Pep-25. Our results show that the elicitor Pep-25 derived... Read More about Fungal elicitor Pep-25 increases cytosolic calcium ions, H 2O2 production and activates the octadecanoid pathway in Arabidopsis thaliana.

Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves (2009)
Journal Article
Harrison, J., Ribeiro, D. M., Desikan, R., Bright, J., Confraria, A., Hancock, J. T., …Wilson, I. D. (2009). Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves. Plant, Cell and Environment, 32(1), 46-57. https://doi.org/10.1111/j.1365-3040.2008.01906.x

Abscisic acid (ABA)-induced stomatal closure is mediated by a complex, guard cell signalling network involving nitric oxide (NO) as a key intermediate. However, there is a lack of information concerning the role of NO in the ABA-enhanced stomatal clo... Read More about Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves.

Tools to investigate reaction oxygen species-sensitive signaling proteins (2009)
Book Chapter
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2009). Tools to investigate reaction oxygen species-sensitive signaling proteins. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction (84-96). Humana Press. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate reaction oxygen species-sensitive signaling proteins.

Role of nitric oxide in regulating stomatal apertures (2009)
Journal Article
Wilson, I. D., Ribeiro, D. M., Bright, J., Confraria, A., Harrison, J., Barros, R. S., …Hancock, J. T. (2009). Role of nitric oxide in regulating stomatal apertures. Plant Signaling and Behavior, 4(5), 467-469. https://doi.org/10.4161/psb.4.5.8545

During stomatal closure, nitric oxide (NO) operates as one of the key intermediates in the complex, abscisic acid (ABA)-mediated, guard cell signaling network that regulates this process. However, data concerning the role of NO in stomatal closure th... Read More about Role of nitric oxide in regulating stomatal apertures.

Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae (2008)
Book Chapter
Lewis, M., Amey, R., Schleicher, T., Slinn, J., Lewis, M., Macdonald, H., …Spencer-Phillips, P. T. (2008). Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae. In A. Lebeda, P. T. Spencer-Phillips, & B. Cooke (Eds.), The Downy Mildews - Genetics, Molecular Biology and Control (41-55). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8973-2_5

A proteomic approach was used to identify host proteins altering in abundance during Peronospora viciae infection of a susceptible cultivar of pea (Pisum sativum cv. Livioletta). Proteins were extracted from fully developed pea leaflets at 4 days pos... Read More about Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae.

Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae (2008)
Journal Article
Amey, R., Schleicher, T., Slinn, J., Lewis, M., Macdonald, H., Neill, S., & Spencer-Phillips, P. T. (2008). Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae. European Journal of Plant Pathology, 122(1), 41-55. https://doi.org/10.1007/s10658-008-9313-2

A proteomic approach was used to identify host proteins altering in abundance during Peronospora viciae infection of a susceptible cultivar of pea (Pisum sativum cv. Livioletta). Proteins were extracted from fully developed pea leaflets at 4 days pos... Read More about Proteomic analysis of a compatible interaction between Pisum sativum (pea) and the downy mildew pathogen Peronospora viciae.

The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells (2008)
Journal Article
Desikan, R., Horák, J., Chaban, C., Mira-Rodado, V., Witthöft, J., Elgass, K., …Harter, K. (2008). The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells. PLoS ONE, 3(6), 1-15. https://doi.org/10.1371/journal.pone.0002491

Background: Stomatal guard cells monitor and respond to environmental and endogenous signals such that the stomatal aperture is continually optimised for water use efficiency. A key signalling molecule produced in guard cells in response to plant hor... Read More about The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells.

Expression analysis of Arabidopsis vacuolar sorting receptor 3 reveals a putative function in guard cells (2008)
Journal Article
Avila, E. L., Brown, M., Pan, S., Desikan, R., Neill, S., Girke, T., …Raikhel, N. V. (2008). Expression analysis of Arabidopsis vacuolar sorting receptor 3 reveals a putative function in guard cells. Journal of Experimental Botany, 59(6), 1149-1161. https://doi.org/10.1093/jxb/ern025

Vacuolar sorting receptors (VSRs) are responsible for the proper targeting of soluble cargo proteins to their destination compartments. The Arabidopsis genome encodes seven VSRs. In this work, the spatio-temporal expression of one of the members of t... Read More about Expression analysis of Arabidopsis vacuolar sorting receptor 3 reveals a putative function in guard cells.

Nitric oxide, stomatal closure, and abiotic stress (2008)
Journal Article
Ribeiro, D., Harrison, J., Neill, S., Barros, R. S., Bright, J., Desikan, R., …Wilson, I. D. (2008). Nitric oxide, stomatal closure, and abiotic stress. Journal of Experimental Botany, 59(2), 165-176. https://doi.org/10.1093/jxb/erm293

Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO, usually in the fo... Read More about Nitric oxide, stomatal closure, and abiotic stress.

Nitric oxide signalling in plants (2008)
Journal Article
Wilson, I. D., Neill, S., & Hancock, J. T. (2008). Nitric oxide signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide signalling in plants.

Tools to investigate ROS sensitive signalling proteins (2008)
Journal Article
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2008). Tools to investigate ROS sensitive signalling proteins. Methods in Molecular Biology, 476, 87-99. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate ROS sensitive signalling proteins.

Nitric oxide evolution and perception (2008)
Journal Article
Harrison, J., Neill, S., Bright, J., Desikan, R., Hancock, J. T., & Wilson, I. D. (2008). Nitric oxide evolution and perception. Journal of Experimental Botany, 59(1), 25-35. https://doi.org/10.1093/jxb/erm218

Various experimental data indicate signalling roles for nitric oxide (NO) in processes such as xylogenesis, programmed cell death, pathogen defence, flowering, stomatal closure, and gravitropism. However, it still remains unclear how NO is synthesize... Read More about Nitric oxide evolution and perception.

Nitric oxide, stomatal closure and abiotic stress (2007)
Journal Article
Neill, S., Barros, R. S., Bright, J., Desikan, R., Hancock, J. T., Harrison, J., …Ribeiro, D. M. (2007). Nitric oxide, stomatal closure and abiotic stress. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 146(4), S257. https://doi.org/10.1016/j.cbpa.2007.01.648

Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO (usually in the fo... Read More about Nitric oxide, stomatal closure and abiotic stress.

Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis (2006)
Journal Article
Desikan, R., Last, K., Harrett-Williams, R., Tagliavia, C., Harter, K., Hooley, R., …Neill, S. (2006). Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis. Plant Journal, 47(6), 907-916. https://doi.org/10.1111/j.1365-313X.2006.02842.x

Ethylene is a plant hormone that regulates many aspects of growth and development. Despite the well-known association between ethylene and stress signalling, its effects on stomatal movements are largely unexplored. Here, genetic and physiological da... Read More about Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis.

Doing the unexpected: Proteins involved in hydrogen peroxide perception (2006)
Journal Article
Harrison, J., Hancock, J., Desikan, R., Bright, J., Hooley, R., & Neill, S. (2006). Doing the unexpected: Proteins involved in hydrogen peroxide perception. Journal of Experimental Botany, 57(8), 1711-1718. https://doi.org/10.1093/jxb/erj180

A look back at the early literature on reactive oxygen species (ROS) gives the impression that these small inorganic molecules had a singular defined role, that of host defence in mammalian systems. However, it is now known that their roles also incl... Read More about Doing the unexpected: Proteins involved in hydrogen peroxide perception.

ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis (2006)
Journal Article
Bright, J., Desikan, R., Hancock, J. T., Weir, I. S., & Neill, S. (2006). ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis. Plant Journal, 45(1), 113-122. https://doi.org/10.1111/j.1365-313X.2005.02615.x

Nitric oxide (NO) and hydrogen peroxide (H2O2) are key signalling molecules produced in response to various stimuli and involved in a diverse range of plant signal transduction processes. Nitric oxide and H 2O2 have been identified as essential compo... Read More about ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis.

Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis (2005)
Journal Article
Harrison, J., Hancock, J. T., Henson, D., Nyirenda, M., Desikan, R., Lewis, M., …Neill, S. (2005). Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis. Plant Physiology and Biochemistry, 43(9), 828-835. https://doi.org/10.1016/j.plaphy.2005.07.012

Hydrogen peroxide (H2O2) is now recognised as a key signalling molecule in eukaryotes. In plants, H2O2 is involved in regulating stomatal closure, gravitropic responses, gene expression and programmed cell death. Although several kinases, such as oxi... Read More about Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis.

Reactive oxygen species as signalling molecules (2005)
Book Chapter
Desikan, R., Hancock, J. T., & Neill, S. (2005). Reactive oxygen species as signalling molecules. In N. Smirnoff (Ed.), Antioxidants and Reactive Oxygen Species in Plants. Wiley

New equations for redox and nano-signal transduction (2004)
Journal Article
Hancock, J. T., Desikan, R., Neill, S., & Cross, A. R. (2004). New equations for redox and nano-signal transduction. Journal of Theoretical Biology, 226(1), 65-68. https://doi.org/10.1016/j.jtbi.2003.08.003

Cells maintain redox potentials (Eh) in intracellular compartments, sometimes referred to as redox environments. These potentials are often very reducing, for example in the cytoplasm, but throughout the cell different potentials are maintained, comm... Read More about New equations for redox and nano-signal transduction.

ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells (2004)
Journal Article
Desikan, R., Cheung, M., Bright, J., Henson, D., Hancock, J. T., & Neill, S. (2004). ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells. Journal of Experimental Botany, 55(395), 205-212

Increased synthesis and redistribution of the phytohormone abscisic acid (ABA) in response to water deficit stress initiates an intricate network of signalling pathways in guard cells leading to stomatal closure. Despite the large number of ABA signa... Read More about ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells.

Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L. (2004)
Journal Article
Desikan, R., Cheung, M., Clarke, A., Golding, S., Sagi, M., Fluhr, R., …Neill, S. (2004). Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L. Functional Plant Biology, 31(9), 913-920

The requirement for hydrogen peroxide (H2O2) generation and action during stomatal closure induced by darkness and abscisic acid (ABA) was investigated in pea (Pisum sativum L.). Stomatal closure induced by darkness or ABA was inhibited by the H2O2-s... Read More about Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L..

Oxidative stress signalling (2003)
Book Chapter
Desikan, R., Hancock, J. T., & Neill, S. (2003). Oxidative stress signalling. In H. Hirt, & K. Shinozaki (Eds.), Plant Responses to Abiotic Stress (121-150). Springer-Verlag

Nitric oxide signalling in plants (2003)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2003). Nitric oxide signalling in plants. New Phytologist, 159(1), 11-35. https://doi.org/10.1046/j.1469-8137.2003.00804.x

Recently nitric oxide (NO) has emerged as a key signalling molecule in plants. Here we review the potential sources of endogenous NO, outline the biological processes likely to be mediated by NO, and discuss the downstream signalling processes by whi... Read More about Nitric oxide signalling in plants.

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana (2002)
Journal Article
Desikan, R., Griffiths, R., Hancock, J. T., & Neill, S. (2002). A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, 99(25), 16314-16318. https://doi.org/10.1073/pnas.252461999

The plant hormone abscisic acid (ABA), synthesized in response to water-deficit stress, induces stomatal closure via activation of complex signaling cascades. Recent work has established that nitric oxide (NO) is a key signaling molecule mediating AB... Read More about A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana.

Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species (2002)
Journal Article
Hancock, J. T., Desikan, R., Clarke, A., Hurst, R. D., & Neill, S. (2002). Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species. Plant Physiology and Biochemistry, 40(6-8), 611-617. https://doi.org/10.1016/S0981-9428%2802%2901403-1

It is now clear that reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), and reactive nitrogen species, such as nitric oxide (NO), are produced by plant cells in response to a variety of stresses, including pathogen challenge. Such molec... Read More about Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species.

Hydrogen peroxide and nitric oxide as signalling molecules in plants (2002)
Journal Article
Neill, S., Desikan, R., Clarke, A., Hurst, R. D., & Hancock, J. T. (2002). Hydrogen peroxide and nitric oxide as signalling molecules in plants. Journal of Experimental Botany, 53(372), 1237-1247

It is now clear that hydrogen peroxide (H2O2) and nitric oxide (NO) function as signalling molecules in plants. A wide range of abiotic and biotic stresses results in H2O2 generation, from a variety of sources. H2O2 is removed from cells via a number... Read More about Hydrogen peroxide and nitric oxide as signalling molecules in plants.

Hydrogen peroxide signalling (2002)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2002). Hydrogen peroxide signalling. Current Opinion in Plant Biology, 5(5), 388-395

Regulation of the Arabidopsis transcriptome by oxidative stress (2001)
Journal Article
Neill, S. J., Hancock, J. T., A.-H.-Mackerness, S., Desikan, R., Desikan, R., Mackerness, S., …Neill, S. (2001). Regulation of the Arabidopsis transcriptome by oxidative stress. Plant Physiology, 127(1), 159-172. https://doi.org/10.1104/pp.127.1.159

Oxidative stress, resulting from an imbalance in the accumulation and removal of reactive oxygen species such as hydrogen peroxide (H2O2), is a challenge faced by all aerobic organisms. In plants, exposure to various abiotic and biotic stresses resul... Read More about Regulation of the Arabidopsis transcriptome by oxidative stress.