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Prof Michael Ladomery

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Michael Ladomery

Associate Professor in Genetics


Regulation of Vascular Endothelial Growth Factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: A novel therapeutic strategy for angiogenesis (2010)
Journal Article
Ladomery, M. R., Amin, E. M., Nowak, D. G., Amin, E. M., Rennel, E. S., Hoareau-Aveilla, C., …Bates, D. O. (2010). Regulation of Vascular Endothelial Growth Factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: A novel therapeutic strategy for angiogenesis. Journal of Biological Chemistry, 285(8), 5532-5540. https://doi.org/10.1074/jbc.M109.074930

Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon. Proximal splice site selection (PSS) in exon 8 generates pro-angiogenic isofor... Read More about Regulation of Vascular Endothelial Growth Factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: A novel therapeutic strategy for angiogenesis.

A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8 (2010)
Journal Article
Hancock, J., Wilson, I., Schmidt, F., Marnef, A., Cheung, M. K., Wilson, I. D., …Ladomery, M. (2010). A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8. Molecular Biology Reports, 37(2), 839-845. https://doi.org/10.1007/s11033-009-9636-x

Plants are highly adapted to respond to a range of environmental stresses commonly by altering their gene expression and metabolism as a result of cell signalling which may be mediated by reactive oxygen species. The glycine-rich RNA-binding proteins... Read More about A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8.

P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state (2009)
Journal Article
Camats, M., Kokolo, M., Heesom, K. J., Ladomery, M., Bach-Elias, M., & Blagosklonny, M. V. (2009). P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state. PLoS ONE, 4(12), e8513. https://doi.org/10.1371/journal.pone.0008513

Background: Three functional c-ras genes, known as c-H-ras, c-K-ras, and c-N-ras, have been largely studied in mammalian cells with important insights into normal and tumorigenic cellular signal transduction events. Two K-Ras mRNAs are obtained from... Read More about P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state.

RAP55: Insights into an evolutionarily conserved protein family (2009)
Journal Article
Ladomery, M. R., Marnef, A., Sommerville, J., & Ladomery, M. (2009). RAP55: Insights into an evolutionarily conserved protein family. International Journal of Biochemistry and Cell Biology, 41(5), 977-981. https://doi.org/10.1016/j.biocel.2008.06.015

The RAP55 protein family is evolutionarily conserved in eukaryotes. Two highly conserved paralogues, RAP55A and RAP55B, exist in vertebrates; their functional properties and expression patterns remain to be compared. RAP55 proteins share multiple dom... Read More about RAP55: Insights into an evolutionarily conserved protein family.

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors (2008)
Journal Article
Ladomery, M. R., Amin, E. M., Nowak, D. G., Woolard, J., Amin, E. M., Konopatskaya, O., …Bates, D. O. (2008). Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. Journal of Cell Science, 121(20), 3487-3495. https://doi.org/10.1242/jcs.016410

Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis. Two families of VEGF isoforms are generated by alternate splice-site selection in the terminal exon. Proxim... Read More about Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes (2008)
Journal Article
Ladomery, M. R., Morrison, A. A., Viney, R. L., Saleem, M. A., & Ladomery, M. (2008). New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. AJP - Renal Physiology, 295(1), F12-F17. https://doi.org/10.1152/ajprenal.00597.2007

The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to... Read More about New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein (2008)
Journal Article
Ladomery, M. R., Morrison, A. A., Viney, R. L., & Ladomery, M. (2008). The post-transcriptional roles of WT1, a multifunctional zinc-finger protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1785(1), 55-62. https://doi.org/10.1016/j.bbcan.2007.10.002

WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C2-H2 zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple level... Read More about The post-transcriptional roles of WT1, a multifunctional zinc-finger protein.

Alternative splicing in angiogenesis: The vascular endothelial growth factor paradigm (2007)
Journal Article
Ladomery, M. R., Ladomery, M., Harper, S. J., & Bates, D. O. (2007). Alternative splicing in angiogenesis: The vascular endothelial growth factor paradigm. Cancer Letters, 249(2), 133-142. https://doi.org/10.1016/j.canlet.2006.08.015

Alternative splicing, first discovered in the 1970s, has emerged as one of the key generators of proteomic diversity. Not surprisingly, alternative splicing is increasingly linked to the etiology of cancer. This is illustrated by vascular endothelial... Read More about Alternative splicing in angiogenesis: The vascular endothelial growth factor paradigm.

A proteomic investigation of glomerular podocytes from a Denys-Drash Syndrome patient with a mutation in the Wilms tumour suppressor gene WT1 (2007)
Journal Article
Ladomery, M. R., Van Den Heuver, L. P., Viney, R. L., Morrison, A. A., van den Heuvel, L. P., Ni, L., …Ladomery, M. (2007). A proteomic investigation of glomerular podocytes from a Denys-Drash Syndrome patient with a mutation in the Wilms tumour suppressor gene WT1. Proteomics, 7(5), 804-815. https://doi.org/10.1002/pmic.200600666

Glomerular podocytes are essential for blood filtration in the kidney underpinned by their unique cytoskeletal morphology. An increasing number of kidney diseases are being associated with key podocyte abnormalities. The Wilms tumour suppressor gene... Read More about A proteomic investigation of glomerular podocytes from a Denys-Drash Syndrome patient with a mutation in the Wilms tumour suppressor gene WT1.

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