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Prof Michael Ladomery

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Michael Ladomery

Associate Professor in Genetics


The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation (2015)
Journal Article
Wilson, I., Hancock, J., Ciuzan, O., Hancock, J. T., Pamfil, D., Wilson, I. D., & Ladomery, M. (2015). The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation. Physiologia Plantarum, 153(1), 1-11. https://doi.org/10.1111/ppl.12286

© 2014 Scandinavian Plant Physiology Society. The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain... Read More about The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.

Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence (2014)
Journal Article
Ladomery, M. R., Hagen, R. M., Adamo, P., Karamat, S., Oxley, J., Aning, J. J., …Rhodes, A. (2014). Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence. American Journal of Clinical Pathology, 142(4), 533-540. https://doi.org/10.1309/AJCPH88QHXARISUP

© American Society for Clinical Pathology. Objectives: The proto-oncogene ETS-related gene (ERG) is consistently overexpressed in prostate cancer. Alternatively spliced isoforms of ERG have variable biological activities; inclusion of exon 11 (72 bas... Read More about Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence.

Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells (2013)
Journal Article
Ladomery, M. R., Morse, H. R., Bowler, E., Mintoff, C. P., Chedea, V. S., Hagen, R. M., & Ladomery, M. (2013). Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. International Journal of Oncology, 43(1), 194-200. https://doi.org/10.3892/ijo.2013.1920

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell s... Read More about Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells.

Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent (2013)
Journal Article
Hagen, R., Rhodes, A., & Ladomery, M. (2013). Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent. Anticancer Research, 33(10), 4395-4400

BACKGROUND: In this study, responses to fatty acid treatments in commonly used prostate cancer cell culture models and variability of gene expression between them were determined. MATERIALS AND METHODS: PC3, DU145, LNCaP, VCaP and PNT2 cells... Read More about Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent.

Role of splice variants in the metastatic progression of prostate cancer (2012)
Journal Article
Ladomery, M. R., Hagen, R. M., & Ladomery, M. (2012). Role of splice variants in the metastatic progression of prostate cancer. Biochemical Society Transactions, 40(4), 870-874. https://doi.org/10.1042/BST20120026

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated gen... Read More about Role of splice variants in the metastatic progression of prostate cancer.

WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing (2011)
Journal Article
Ladomery, M. R., Bates, D. O., Hinton, D. R., Harper, S. J., Schumacher, V. A., Saleem, M. A., …Ladomery, M. (2011). WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing. Cancer Cell, 20(6), 768-780. https://doi.org/10.1016/j.ccr.2011.10.016

Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic VEGF 165b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress VEGF 165b and cause abnormal gonadogenesis, renal failure, and Wilms' tumors... Read More about WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing.

Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA (2010)
Journal Article
Ladomery, M. R., Nurmemmedov, E., Yengo, R. K., Ladomery, M., & Thunnissen, M. M. (2010). Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA. Archives of Biochemistry and Biophysics, 497(1-2), 21-27. https://doi.org/10.1016/j.abb.2010.02.013

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA t... Read More about Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA.

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