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Uptake and translocation of foliar applied phosphite and its effect on growth and development in cool season turfgrass (2022)
Journal Article
Dempsey, J. J., Wilson, I., Spencer-Phillips, P. T. N., & Arnold, D. L. (2022). Uptake and translocation of foliar applied phosphite and its effect on growth and development in cool season turfgrass. Journal of Plant Nutrition, 45(13), 2003-2022. https://doi.org/10.1080/01904167.2022.2044489

Phosphate (PO43-, Pi) is the sole phosphorus (P) containing compound utilized for plant growth, leading to the widespread use of Pi containing fertilizers. An alternative form of P, phosphite (PO33-, Phi) has increasingly been used in many crop syste... Read More about Uptake and translocation of foliar applied phosphite and its effect on growth and development in cool season turfgrass.

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Porazinski, S., Li, L., Clark, B., Ajiro, M., Iida, K., …Ladomery, M. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), Article 7963. https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer (2020)
Journal Article
Li, L., Hobson, L., Perry, L., Clark, B., Heavey, S., Haider, A., …Ladomery, M. (2020). Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. British Journal of Cancer, 123, 1024-1032. https://doi.org/10.1038/s41416-020-0951-2

Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of prostate cancer. It is activated through a fusion with the androgen-responsive TMPRSS2 promoter in 50% of cases. There is therefor... Read More about Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.

Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii (2019)
Journal Article
Al-Hijab, L., Gregg, A., Davies, R., Macdonald, H., Ladomery, M., & Wilson, I. (2019). Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii. Scientific Reports, 9(1), Article 12063. https://doi.org/10.1038/s41598-019-48632-0

© 2019, The Author(s). The phytohormone abscisic acid (ABA) plays a role in stresses that alter plant water status and may also regulate root gravitropism and hydrotropism. ABA also exists in the aquatic algal progenitors of land plants, but other th... Read More about Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article
Jumbe, S., Porazinski, S., Oltean, S., Mansell, J., Vahabi, B., Wilson, I., & Ladomery, M. (2019). The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties. Translational Oncology, 12(1), 134-142. https://doi.org/10.1016/j.tranon.2018.09.001

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Suppression of the in vitro growth and development of Microdochium nivale by phosphite (2018)
Journal Article
Dempsey, J., Wilson, I. D., Spencer-Phillips, P., & Arnold, D. L. (2018). Suppression of the in vitro growth and development of Microdochium nivale by phosphite. Plant Pathology, 67(6), 1296-1306. https://doi.org/10.1111/ppa.12846

© 2018 British Society for Plant Pathology The ascomycete fungus Microdochium nivale is a major pathogen of many species of the gramineae. Control measures rely heavily on chemical fungicides, making alternative means of disease reduction desirable.... Read More about Suppression of the in vitro growth and development of Microdochium nivale by phosphite.

Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention (2018)
Journal Article
Uzor, S., Zorzou, P., Bowler, E., Porazinski, S., Wilson, I. D., & Ladomery, M. (2018). Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention. Gene, 670, 46-54. https://doi.org/10.1016/j.gene.2018.05.095

© 2018 Elsevier B.V. Alternative splicing is a key process required for the regulation of gene expression in normal development and physiology. It is regulated by splice factors whose activities are in turn regulated by splice factor kinases and phos... Read More about Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article
Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., …Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18(1), 355. https://doi.org/10.1186/s12885-018-4227-7

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells (2017)
Journal Article
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M. K., …Ladomery, M. (2017). The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncology Letters, 14(5), 5605-5610. https://doi.org/10.3892/ol.2017.6841

© 2017, Spandidos Publications. All rights reserved. The oncogene ETS-related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. The ERG oncoge... Read More about The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells.

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans (2017)
Journal Article
Floyd, K. G., Hopewell, H., Burnell, D., Hancock, J. T., Allainguillaume, J., Ladomery, M., & Wilson, I. D. (2017). Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans. Ecotoxicology, 26(7), 981-990. https://doi.org/10.1007/s10646-017-1826-z

© 2017, The Author(s). This study investigated the neurological effects of residual ground-water levels of thiaclopridon the non-target organism Caenorhabditis elegans. Nematodes treated with thiacloprid showed a dose-dependent and significantly incr... Read More about Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans.

Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling (2015)
Journal Article
Chater, C., Peng, K., Movahedi, M., Dunn, J. A., Walker, H. J., Liang, Y., …Hetherington, A. M. (2015). Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling. Current Biology, 25(20), 2709-2716. https://doi.org/10.1016/j.cub.2015.09.013

© 2015 The Authors. An integral part of global environment change is an increase in the atmospheric concentration of CO2 ([CO2]) [1]. Increased [CO2] reduces leaf stomatal apertures and density of stomata that plays out as reductions in evapotranspir... Read More about Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling.

Detection of thiol modifications by hydrogen sulfide (2015)
Book Chapter
Williams, E., Pead, S., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M., …Hancock, J. T. (2015). Detection of thiol modifications by hydrogen sulfide. In E. Cadenas, & L. Packer (Eds.), Hydrogen Sulfide in Redox Biology Part B (233-251). UK: Academic Press

The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation (2015)
Journal Article
Wilson, I., Ciuzan, O., Hancock, J. T., Pamfil, D., Wilson, I. D., & Ladomery, M. (2015). The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation. Physiologia Plantarum, 153(1), 1-11. https://doi.org/10.1111/ppl.12286

© 2014 Scandinavian Plant Physiology Society. The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain... Read More about The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.

Hydrogen sulfide: Environmental factor or signalling molecule? (2013)
Journal Article
Lisjak, M., Lisjak, M., Teklic, T., Wilson, I. D., Whiteman, M., & Hancock, J. T. (2013). Hydrogen sulfide: Environmental factor or signalling molecule?. Plant, Cell and Environment, 36(9), 1607-1616. https://doi.org/10.1111/pce.12073

Hydrogen sulfide (H2S) has traditionally been thought of as a phytotoxin, having deleterious effects on the plant growth and survival. It is now recognized that plants have enzymes which generate H2S, cysteine desulfhydrase, and remove it, O-acetylse... Read More about Hydrogen sulfide: Environmental factor or signalling molecule?.

Suppression of Microdochium nivale by potassium phosphite in cool-season turfgrasses (2012)
Journal Article
Dempsey, J. J., Wilson, I. D., Spencer-Phillips, P. T., & Arnold, D. L. (2012). Suppression of Microdochium nivale by potassium phosphite in cool-season turfgrasses. Acta Agriculturae Scandinavica, Section B - Soil and Plant Science, 62(SUPPL.1), 70-78. https://doi.org/10.1080/09064710.2012.681392

Microdochium nivale (Fr.) Samuels and Hallett (teleomorph Monographella nivalis (Schafnitt) is one of the most damaging pathogens of cool-season amenity turfgrasses. The search for new or improved means to reduce susceptibility to M. nivale is an ong... Read More about Suppression of Microdochium nivale by potassium phosphite in cool-season turfgrasses.

The relationship of proline content and metabolism on the productivity of maize plants (2011)
Journal Article
Teklić, T., Agić, D., Špoljarević, M., Lisjak, M., Gumze, A., Wilson, I. D., & Hancock, J. T. (2011). The relationship of proline content and metabolism on the productivity of maize plants. Plant Signaling and Behavior, 6(2), 251-257. https://doi.org/10.4161/psb.6.2.14336

The free proline content in maize ear-leaves, silk and pollen were analyzed in field grown plants which had matured to the pollination stage. Using maize hybrids PR34F02, PR35P12 and PR36B08 field trials were set up at two locations in eastern croati... Read More about The relationship of proline content and metabolism on the productivity of maize plants.

Hydrogen sulfide effects on stomatal apertures (2011)
Journal Article
Lisjak, M., Teklic, T., Wilson, I. D., Wood, M., Whiteman, M., & Hancock, J. T. (2011). Hydrogen sulfide effects on stomatal apertures. Plant Signaling and Behavior, 6(10), 1444-1446

Nitric oxide and ABA in the control of plant function (2011)
Journal Article
Hancock, J. T., Neill, S., & Wilson, I. D. (2011). Nitric oxide and ABA in the control of plant function. Plant Science, 181(5), 555-559. https://doi.org/10.1016/j.plantsci.2011.03.017

Abscisic acid (ABA) and nitric oxide (NO) are both extremely important signalling molecules employed by plants to control many aspects of physiology. ABA has been extensively studied in the mechanisms which control stomatal movement as well as in see... Read More about Nitric oxide and ABA in the control of plant function.

A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation (2010)
Journal Article
Lisjak, M., Srivastava, N., Teklic, T., Civale, L., Lewandowski, K., Wilson, I. D., …Hancock, J. T. (2010). A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation. Plant Physiology and Biochemistry, 48(12), 931-935. https://doi.org/10.1016/j.plaphy.2010.09.016

Effects of hydrogen sulfide (H2S) on plant physiology have been previously studied, but such studies have relied on the use of NaSH as a method for supplying H2S to tissues. Now new compounds which give a less severe H2S shock and a more prolonged ex... Read More about A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.

Plant responses to cold: transcriptome analysis of wheat (2010)
Journal Article
Winfield, M. O., Lu, C., Wilson, I. D., Coghill, J. A., & Edwards, K. J. (2010). Plant responses to cold: transcriptome analysis of wheat. Plant Biotechnology Journal, 8(7), 749-771. https://doi.org/10.1111/j.1467-7652.2010.00536.x

Temperature and light are important environmental stimuli that have a profound influence on the growth and development of plants. Wheat varieties can be divided on the basis of whether they require an extended period of cold to flower (vernalization)... Read More about Plant responses to cold: transcriptome analysis of wheat.

A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8 (2010)
Journal Article
Schmidt, F., Marnef, A., Cheung, M. K., Wilson, I. D., Hancock, J. T., Staiger, D., & Ladomery, M. (2010). A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8. Molecular Biology Reports, 37(2), 839-845. https://doi.org/10.1007/s11033-009-9636-x

Plants are highly adapted to respond to a range of environmental stresses commonly by altering their gene expression and metabolism as a result of cell signalling which may be mediated by reactive oxygen species. The glycine-rich RNA-binding proteins... Read More about A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8.

Reactive oxygen species, nitric oxide and signal crosstalk (2009)
Book Chapter
Neill, S., Hancock, J. T., & Wilson, I. D. (2009). Reactive oxygen species, nitric oxide and signal crosstalk. In K. Yoshioka, & K. Shinozaki (Eds.), Signal Crosstalk in Plant Stress Responses (136-160). Iowa: Wiley-Blackwell

Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress (2009)
Journal Article
Lisjak, M., Wilson, I. D., Civale, L., Hancock, J. T., & Teklic, T. (2009). Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress. Agriculture, 15, 32-37

High rainfall and rapid water uptake by dry seed after sowing in the field can result in so-called seed imbibitional damage. Here, lipid peroxidation levels were evaluated in seed testa, embryos and cotyledons of three soybean cultivars (Podravka 95,... Read More about Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress.

Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves (2009)
Journal Article
Harrison, J., Ribeiro, D. M., Desikan, R., Bright, J., Confraria, A., Hancock, J. T., …Wilson, I. D. (2009). Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves. Plant, Cell and Environment, 32(1), 46-57. https://doi.org/10.1111/j.1365-3040.2008.01906.x

Abscisic acid (ABA)-induced stomatal closure is mediated by a complex, guard cell signalling network involving nitric oxide (NO) as a key intermediate. However, there is a lack of information concerning the role of NO in the ABA-enhanced stomatal clo... Read More about Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves.

Role of nitric oxide in regulating stomatal apertures (2009)
Journal Article
Wilson, I. D., Ribeiro, D. M., Bright, J., Confraria, A., Harrison, J., Barros, R. S., …Hancock, J. T. (2009). Role of nitric oxide in regulating stomatal apertures. Plant Signaling and Behavior, 4(5), 467-469. https://doi.org/10.4161/psb.4.5.8545

During stomatal closure, nitric oxide (NO) operates as one of the key intermediates in the complex, abscisic acid (ABA)-mediated, guard cell signaling network that regulates this process. However, data concerning the role of NO in stomatal closure th... Read More about Role of nitric oxide in regulating stomatal apertures.

Cold- and light-induced changes in the transcriptome of wheat leading to phase transition from vegetative to reproductive growth (2009)
Journal Article
Edwards, K. J., Coghill, J. A., Winfield, M. O., Lu, C., & Wilson, I. D. (2009). Cold- and light-induced changes in the transcriptome of wheat leading to phase transition from vegetative to reproductive growth. BMC Plant Biology, 9(55), 1-14. https://doi.org/10.1186/1471-2229-9-55

Abstract. Background. For plants to flower at the appropriate time, they must be able to perceive and respond to various internal and external cues. Wheat is generally a long-day plant that will go through phase transition from vegetative to floral g... Read More about Cold- and light-induced changes in the transcriptome of wheat leading to phase transition from vegetative to reproductive growth.

SlTPR1, a tomato tetratricopeptide repeat protein, interacts with the ethylene receptors NR and LeETR1, modulating ethylene and auxin responses and development (2008)
Journal Article
Lin, Z., Arciga-Reyes, L., Zhong, S., Alexander, L., Hackett, R., Wilson, I., & Grierson, D. (2008). SlTPR1, a tomato tetratricopeptide repeat protein, interacts with the ethylene receptors NR and LeETR1, modulating ethylene and auxin responses and development. Journal of Experimental Botany, 59(15), 4271-4287. https://doi.org/10.1093/jxb/ern276

The gaseous hormone ethylene is perceived by a family of ethylene receptors which interact with the Raf-like kinase CTR1. SlTPR1 encodes a novel TPR (tetratricopeptide repeat) protein from tomato that interacts with the ethylene receptors NR and LeET... Read More about SlTPR1, a tomato tetratricopeptide repeat protein, interacts with the ethylene receptors NR and LeETR1, modulating ethylene and auxin responses and development.

Nitric oxide, stomatal closure, and abiotic stress (2008)
Journal Article
Ribeiro, D., Harrison, J., Neill, S., Barros, R. S., Bright, J., Desikan, R., …Wilson, I. D. (2008). Nitric oxide, stomatal closure, and abiotic stress. Journal of Experimental Botany, 59(2), 165-176. https://doi.org/10.1093/jxb/erm293

Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO, usually in the fo... Read More about Nitric oxide, stomatal closure, and abiotic stress.

Nitric oxide evolution and perception (2008)
Journal Article
Harrison, J., Neill, S., Bright, J., Desikan, R., Hancock, J. T., & Wilson, I. D. (2008). Nitric oxide evolution and perception. Journal of Experimental Botany, 59(1), 25-35. https://doi.org/10.1093/jxb/erm218

Various experimental data indicate signalling roles for nitric oxide (NO) in processes such as xylogenesis, programmed cell death, pathogen defence, flowering, stomatal closure, and gravitropism. However, it still remains unclear how NO is synthesize... Read More about Nitric oxide evolution and perception.

Nitric oxide signalling in plants (2008)
Journal Article
Wilson, I. D., Neill, S., & Hancock, J. T. (2008). Nitric oxide signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide signalling in plants.

Nitric oxide synthesis and signalling in plants (2008)
Journal Article
Neill, S. J., Wilson, I. D., & Hancock, J. T. (2008). Nitric oxide synthesis and signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide synthesis and signalling in plants.

Transcriptome Shock after Interspecific Hybridization in Senecio Is Ameliorated by Genome Duplication (2006)
Journal Article
Hegarty, M. J., Barker, G. L., Wilson, I. D., Abbott, R. J., Edwards, K. J., & Hiscock, S. J. (2006). Transcriptome Shock after Interspecific Hybridization in Senecio Is Ameliorated by Genome Duplication. Current Biology, 16(16), 1652-1659. https://doi.org/10.1016/j.cub.2006.06.071

Allopolyploidy, which involves genome doubling of an interspecific hybrid is an important mechanism of abrupt speciation in flowering plants [1-6]. Recent studies show that allopolyploid formation is accompanied by extensive changes to patterns of pa... Read More about Transcriptome Shock after Interspecific Hybridization in Senecio Is Ameliorated by Genome Duplication.

A pilot investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon low back pain in people with multiple sclerosis (2003)
Journal Article
Lowe-Strong, A. S., Walsh, D. M., Al-Smadi, J., Warke, K., Wilson, I., Cramp, F. (., & Noble, G. (2003). A pilot investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon low back pain in people with multiple sclerosis. Clinical Rehabilitation, 17(7), 742-749. https://doi.org/10.1191/0269215503cr672oa

Objective: To investigate the hypoalgesic effects of transcutaneous electrical nerve stimulation (TENS) upon low back pain (LBP) in people with multiple sclerosis (MS). Design: A randomized double-blind placebo controlled clinical pilot study. Subjec... Read More about A pilot investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon low back pain in people with multiple sclerosis.