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Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue (2006)
Journal Article
Wood, J. D., Whittington, F. M., McGivan, J. D., Nicolau-Solano, S. I., Nieuwhof, G. J., & Doran (nee Udovikova), O. (2006). Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue. Journal of Animal Science, 84(10), 2809-2817. https://doi.org/10.2527/jas.2005-595

This study investigated the relationship between expression of hepatic and testicular 3/3-hydroxysteroid dehydrogenase (3/3-HSD) and accumulation of androstenone in adipose tissue because of its relation to boar taint. The experiments were performed... Read More about Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue.

A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation (2006)
Journal Article
Doran (nee Udovikova), O., Moule, S. K., Teye, G. A., Whittington, F. M., Hallett, K. G., & Wood, J. D. (2006). A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation. British Journal of Nutrition, 95(3), 609-617. https://doi.org/10.1079/BJN20051526

A reduced protein diet (RPD) is known to increase the level of intramuscular lipid in pig meat with a smaller effect on the amount of subcutaneous adipose tissue. This might be due to tissue-specific activation of the expression of lipogenic enzymes... Read More about A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation.

Functional analyses of the pig CYP2E1 promoter and identification of the transcription factors required for CYP2E1 expression (2006)
Book Chapter
Doran (nee Udovikova), O., McGivan, J. D., Cue, R. A., & Wood, J. D. (2006). Functional analyses of the pig CYP2E1 promoter and identification of the transcription factors required for CYP2E1 expression. In Y. van der Honing (Ed.), Book of Abstracts of the 57th Annual Meeting of the European Association for Animal Production (268). Wageningen Academic Publishing

Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig (2005)
Journal Article
McGivan, J. D., Skinner, T. M., Doran (nee Udovikova), O., Haley, C. S., & Archibald, A. L. (2005). Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig. Animal Genetics, 36(5), 417-422. https://doi.org/10.1111/j.1365-2052.2005.01342.x

The porcine cytochrome-p450 2E1 (CYP2E1) gene was isolated by screening a pig BAC library and partially sequenced. This sequence information was used to identify six single nucleotide polymorphisms (SNPs) within the CYP2E1 gene and its promoter. In a... Read More about Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig.

Inhibition of CYP2E1 expression by androstenone: Relation to boar taint (2005)
Book Chapter
Doran (nee Udovikova), O., McGivan, J. D., Whittington, F. M., Tambyrajah, W., & Wood, J. D. (2005). Inhibition of CYP2E1 expression by androstenone: Relation to boar taint. In Y. van der Honing (Ed.), Book of Abstracts of the 56th Annual Meeting of the European Association for Animal Production (325). Wageningen Academic Publishing

The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone (2004)
Journal Article
Doran, E., Tambyrajah, W. S., Doran (nee Udovikova), O., Wood, J. D., & McGivan, J. D. (2004). The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Archives of Biochemistry and Biophysics, 431(2), 252-260. https://doi.org/10.1016/j.abb.2004.08.016

Functional analysis of the pig cytochrome P4502E1 (CYP2E1) promoter identified two major activating elements. One corresponded to the hepatic nuclear factor 1 (HNF-1) consensus binding sequence at nucleotides -128/-98 and the other was located in the... Read More about The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone.

Characterisation of androstenone metabolism in pig liver microsomes (2004)
Journal Article
Doran (nee Udovikova), O., Whittington, F. M., Wood, J. D., & McGivan, J. D. (2004). Characterisation of androstenone metabolism in pig liver microsomes. Chemico-Biological Interactions, 147(2), 141-149. https://doi.org/10.1016/j.cbi.2003.12.002

Androstenone (5α-androst-16-en-3-one) is a steroid pheromone produced in the testis. Excessive accumulation of androstenone together with skatole (3-methyl-indole) in the adipose tissue of some male pigs leads to "boar taint". In isolated pig hepatoc... Read More about Characterisation of androstenone metabolism in pig liver microsomes.

Liver androstenone metabolism in relation to boar taint (2003)
Book Chapter
Doran (nee Udovikova), O., Whittington, F. M., Wood, J. D., & McGivan, J. D. (2003). Liver androstenone metabolism in relation to boar taint. In Y. van der Honing (Ed.), Book of Abstracts of the 54th Annual Meeting of the European Association for Animal Production (93). Wageningen Academic Publishers

Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes (2002)
Journal Article
Wood, J. D., Doran (nee Udovikova), O., Whittington, F., & McGivan, J. D. (2002). Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions, 140(1), 81-92. https://doi.org/10.1016/S0009-2797%2802%2900015-7

Skatole, a derivative of tryptophan, is produced in the hind-gut of pigs and is metabolised via hepatic cytochrome P4502E1 (CYP2E1). Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some... Read More about Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes.

Diagnostic assay for boar taint (2002)
Patent
McGivan, J. D., Wood, J. D., Whittington, F. M., Doran (nee Udovikova), O., & Meat and Livestock Commission, N. (2002). Diagnostic assay for boar taint. WO/2002/024945

(EN) The present invention discloses a link between the level of cytochrome P450 isoform P4502E1 and the level of skatole. A polynucleotide encoding the sequence for P4502E1 and a polynucleotide encoding the sequence for P4502E1 and a polynucleotide... Read More about Diagnostic assay for boar taint.