All Outputs (153)

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial (2019)
Journal Article
Hartshorn, S., Barrett, M. J., Lyttle, M. D., Yee, S. A., & Irvine, A. T. (2019). Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial. Trials, 20, Article 393 (2019). https://doi.org/10.1186/s13063-019-3511-4

Background Pain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual assessment and... Read More about Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial.

Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland (2019)
Journal Article
Jahn, H. K., Jahn, I. H., Roland, D., Lyttle, M. D., & Behringer, W. (2019). Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland. Archives of Disease in Childhood, 104(12), 1203-1207. https://doi.org/10.1136/archdischild-2019-316872

Introduction Mobile devices and medical apps are used by healthcare professionals in adult and paediatric emergency departments worldwide. Recently, there has been a drive toward increased digitalisation especially in the UK. This point prevalence su... Read More about Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland.

Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis (2019)
Journal Article
Woolfall, K., O'Hara, C., Deja, E., Canter, R., Khan, I., Mouncey, P., …Inwald, D. (2019). Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis. Archives of Disease in Childhood, 104(11), 1077-1082. https://doi.org/10.1136/archdischild-2019-316807

Objective: To identify parents' prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection. Design: Qualitative synthesis combining parent interview data from t... Read More about Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis.

Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis (2019)
Journal Article
Jamal, A., Finkelstein, Y., Kuppermann, N., Freedman, S. B., Florin, T. A., Babl, F. E., …Schuh, S. (2019). Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis. Lancet Child and Adolescent Health, 3(8), 539-547. https://doi.org/10.1016/s2352-4642%2819%2930193-2

Background Clinical guidelines advise against pharmacotherapy in bronchiolitis. However, little is known about global variation in prescribing practices for bronchiolitis at discharge from emergency departments. We aimed to evaluate global variation... Read More about Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis.

Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC) (2019)
Journal Article
Waterfield, T., Lyttle, M. D., Shields, M., Fairley, D., Roland, D., McKenna, J., & Woolfall, K. (2019). Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC). Archives of Disease in Childhood, 104(10), 979-983. https://doi.org/10.1136/archdischild-2019-317117

Objective: The Petechiae in Children (PiC) study assesses the utility of presenting features and rapid diagnostic tests in the diagnosis of serious bacterial infection in feverish children with non-blanching rashes. An embedded qualitative study expl... Read More about Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC).

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT) (2019)
Journal Article
Lyttle, M. D., Bielicki, J. A., Barratt, S., Dunn, D., Finn, A., Harper, L., …Sharland, M. (2019). Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT). BMJ Open, 9(5), e029875. https://doi.org/10.1136/bmjopen-2019-029875

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Community-acquired pneumonia (CAP) is a common indication for antibiotic treatment in young children. Data are limited regarding the ideal dose and... Read More about Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT).

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article
Crome, L., Nyirenda, M., Sajjanhar, T., Leighton, S., McLellan, S., Bell, C., …Lyttle, M. D. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 393(10186), 2125-2134. https://doi.org/10.1016/S0140-6736%2819%2930724-X

Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (2019)
Journal Article
Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., …Appleton, R. (2019). Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. Trials, 20, Article 181. https://doi.org/10.1186/s13063-019-3273-z

Background: EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention... Read More about Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study.

Traumatic brain injury in young children with isolated scalp haematoma (2019)
Journal Article
Bressan, S., Kochar, A., Oakley, E., Borland, M., Phillips, N., Dalton, S., …Babl, F. E. (2019). Traumatic brain injury in young children with isolated scalp haematoma. Archives of Disease in Childhood, 104(7), 664-669. https://doi.org/10.1136/archdischild-2018-316066

Objective Despite high-quality paediatric head trauma clinical prediction rules, the management of otherwise asymptomatic young children with scalp haematomas (SH) can be difficult. We determined the risk of intracranial injury when SH is the only pr... Read More about Traumatic brain injury in young children with isolated scalp haematoma.

Incidence of medically attended paediatric burns across the UK (2019)
Journal Article
Davies, K., Johnson, E. L., Hollén, L., Jones, H. M., Lyttle, M. D., Maguire, S., & Kemp, A. M. (2020). Incidence of medically attended paediatric burns across the UK. Injury Prevention, 26(1), 24-30. https://doi.org/10.1136/injuryprev-2018-042881

Objective: Childhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and death... Read More about Incidence of medically attended paediatric burns across the UK.

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis (2019)
Journal Article
Simone, L., Lyttle, M. D., Roland, D., Stephens, D., & Schuh, S. (2019). Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis. Emergency Medicine Journal, 36(3), 148-153. https://doi.org/10.1136/emermed-2018-208000

Background Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants

Delayed presentations to emergency departments of children with head injury: A PREDICT study (2019)
Journal Article
Borland, M. L., Dalziel, S. R., Phillips, N., Lyttle, M. D., Bressan, S., Oakley, E., …Babl, F. E. (2019). Delayed presentations to emergency departments of children with head injury: A PREDICT study. Annals of Emergency Medicine, 74(1), 1-10. https://doi.org/10.1016/j.annemergmed.2018.11.035

© 2018 American College of Emergency Physicians Study objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We... Read More about Delayed presentations to emergency departments of children with head injury: A PREDICT study.

Paediatric intentional head injuries in the emergency department: A multicentre prospective cohort study (2018)
Journal Article
Lyttle, M. D., Babl, F. E., Pfeiffer, H., Dalziel, S. R., Oakley, E., Anderson, V., …Crowe, L. (2019). Paediatric intentional head injuries in the emergency department: A multicentre prospective cohort study. Emergency Medicine Australasia, 31(4), 546-554. https://doi.org/10.1111/1742-6723.13202

© 2018 Australasian College for Emergency Medicine Objective: Although there is a large body of research on head injury (HI) inflicted by caregivers in young children, little is known about intentional HI in older children and inflicted HI by perpetr... Read More about Paediatric intentional head injuries in the emergency department: A multicentre prospective cohort study.

A cost-effectiveness analysis comparing clinical decision rules PECARN, CATCH, and CHALICE with usual care for the management of pediatric head injury (2018)
Journal Article
Dalziel, K., Cheek, J. A., Fanning, L., Borland, M. L., Phillips, N., Kochar, A., …Babl, F. E. (2019). A cost-effectiveness analysis comparing clinical decision rules PECARN, CATCH, and CHALICE with usual care for the management of pediatric head injury. Annals of Emergency Medicine, 73(5), 429-439. https://doi.org/10.1016/j.annemergmed.2018.09.030

© 2018 American College of Emergency Physicians Study objective: To determine the cost-effectiveness of 3 clinical decision rules in comparison to Australian and New Zealand usual care: the Children's Head Injury Algorithm for the Prediction of Impor... Read More about A cost-effectiveness analysis comparing clinical decision rules PECARN, CATCH, and CHALICE with usual care for the management of pediatric head injury.

Defining significant childhood illness and injury in the Emergency Department: A consensus of UK and Ireland expert opinion (2018)
Journal Article
Lillitos, P. J., Lyttle, M. D., Roland, D., Powell, C. V., Sandell, J., Rowland, A. G., …Maconochie, I. K. (2018). Defining significant childhood illness and injury in the Emergency Department: A consensus of UK and Ireland expert opinion. Emergency Medicine Journal, 35(11), 685-690. https://doi.org/10.1136/emermed-2018-207802

© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ. Background Clarifying whether paediatric early warning scores (PEWS) accurately predict significant illness is a research priority for UK and... Read More about Defining significant childhood illness and injury in the Emergency Department: A consensus of UK and Ireland expert opinion.

Preferred learning modalities and practice for critical skills: A global survey of paediatric emergency medicine clinicians (2018)
Journal Article
Craig, S. S., Auerbach, M., Cheek, J. A., Babl, F. E., Oakley, E., Nguyen, L., …Dalziel, S. R. (2019). Preferred learning modalities and practice for critical skills: A global survey of paediatric emergency medicine clinicians. Emergency Medicine Journal, 36(5), 273-280. https://doi.org/10.1136/emermed-2017-207384

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objective To describe senior paediatric emergency clinician perspectives on the optimal frequency of and preferred modalities for practising... Read More about Preferred learning modalities and practice for critical skills: A global survey of paediatric emergency medicine clinicians.

External validation of the Scandinavian guidelines for management of minimal, mild and moderate head injuries in children (2018)
Journal Article
Undén, J., Dalziel, S. R., Borland, M. L., Phillips, N., Kochar, A., Lyttle, M. D., …Babl, F. E. (2018). External validation of the Scandinavian guidelines for management of minimal, mild and moderate head injuries in children. BMC Medicine, 16(1), https://doi.org/10.1186/s12916-018-1166-8

© 2018 The Author(s). Background: Clinical decision rules (CDRs) aid in the management of children with traumatic brain injury (TBI). Recently, the Scandinavian Neurotrauma Committee (SNC) has published practical, evidence-based guidelines for childr... Read More about External validation of the Scandinavian guidelines for management of minimal, mild and moderate head injuries in children.

A Longitudinal Examination of the Relationship between Trauma-Related Cognitive Factors and Internalising and Externalising Psychopathology in Physically Injured Children (2018)
Journal Article
Hiller, R. M., Creswell, C., Meiser-Stedman, R., Lobo, S., Cowdrey, F., Lyttle, M. D., …Halligan, S. L. (2019). A Longitudinal Examination of the Relationship between Trauma-Related Cognitive Factors and Internalising and Externalising Psychopathology in Physically Injured Children. Journal of Abnormal Child Psychology, 47(4), 683-693. https://doi.org/10.1007/s10802-018-0477-8

© 2018, The Author(s). Cognitive models of posttraumatic stress disorder (PTSD) highlight maladaptive posttrauma appraisals, trauma memory qualities, and coping strategies, such as rumination or thought suppression, as key processes that maintain PTS... Read More about A Longitudinal Examination of the Relationship between Trauma-Related Cognitive Factors and Internalising and Externalising Psychopathology in Physically Injured Children.

Epidemiology and aetiology of paediatric traumatic cardiac arrest in England and Wales (2018)
Journal Article
Vassallo, J., Webster, M., Barnard, E. B. G., Lyttle, M. D., & Smith, J. E. (2019). Epidemiology and aetiology of paediatric traumatic cardiac arrest in England and Wales. Archives of Disease in Childhood, 104(5), 437-443. https://doi.org/10.1136/archdischild-2018-314985

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objective To describe the epidemiology and aetiology of paediatric traumatic cardiac arrest (TCA) in England and Wales. Design Population-bas... Read More about Epidemiology and aetiology of paediatric traumatic cardiac arrest in England and Wales.

Paediatric traumatic cardiac arrest: The development of an algorithm to guide recognition, management and decisions to terminate resuscitation (2018)
Journal Article
Vassallo, J., Nutbeam, T., Rickard, A. C., Lyttle, M. D., Scholefield, B., Maconochie, I. K., & Smith, J. E. (2018). Paediatric traumatic cardiac arrest: The development of an algorithm to guide recognition, management and decisions to terminate resuscitation. Emergency Medicine Journal, 35(11), 669-674. https://doi.org/10.1136/emermed-2018-207739

© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Paediatric traumatic cardiac arrest (TCA) is a high acuity, low frequency event. Traditionally, survival from TCA has been repor... Read More about Paediatric traumatic cardiac arrest: The development of an algorithm to guide recognition, management and decisions to terminate resuscitation.