All Outputs (169)

Considerations of the importance of redox state for reactive nitrogen species action (2019)
Journal Article
Hancock, J. T. (2019). Considerations of the importance of redox state for reactive nitrogen species action. Journal of Experimental Botany, 70(17), 4323-4331. https://doi.org/10.1093/jxb/erz067

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not... Read More about Considerations of the importance of redox state for reactive nitrogen species action.

Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article
Hancock, J. T., & Neill, S. J. (2019). Nitric oxide: Its generation and interactions with other reactive signaling compounds. Plants, 8(2), 41. https://doi.org/10.3390/plants8020041

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

The role of redox in signal transduction (2019)
Book Chapter
Hancock, J. T. (2019). The role of redox in signal transduction. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (1-11). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_1

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important? (2018)
Journal Article
Hancock, J. T., & Hancock, T. H. (2018). Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?. Reactive Oxygen Species, 6(18),

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s... Read More about Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?.

Hydrogen sulfide and environmental stresses (2018)
Journal Article
Hancock, J. T. (2019). Hydrogen sulfide and environmental stresses. Environmental and Experimental Botany, 161, 50-56. https://doi.org/10.1016/j.envexpbot.2018.08.034

© 2018 Elsevier B.V. Hydrogen sulfide (H 2 S) is part of a suite of small reactive molecules which are known to be involved in cell signaling events in plants. It is produced by cells, can move around, including through membranes, and can be removed... Read More about Hydrogen sulfide and environmental stresses.

Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2018)
Journal Article
Hancock, J., & Whiteman, M. (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Free Radical Biology and Medicine, 120(S1), s9. https://doi.org/10.1016/j.freeradbiomed.2018.04.040

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molec... Read More about Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article
Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., …Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18(1), 355. https://doi.org/10.1186/s12885-018-4227-7

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Signaling through the primary cilium (2018)
Journal Article
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018). Signaling through the primary cilium. Frontiers in Cell and Developmental Biology, 6(FEB), https://doi.org/10.3389/fcell.2018.00008

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remainin... Read More about Signaling through the primary cilium.

Cellular redox environment and its influence on redox signalling molecules (2018)
Journal Article
Hancock, J. T., & Whiteman, M. (2018). Cellular redox environment and its influence on redox signalling molecules. Reactive Oxygen Species, 5(14),

The redox potential of a cell’s internal environment is well recognised as important for controlling cellular activities. Both animal and plant cells generate and are exposed to a range of reactive molecules involved in cell signalling, including rea... Read More about Cellular redox environment and its influence on redox signalling molecules.

Hydrogen gas and its role in cell signaling (2017)
Journal Article
Wilson, H. R., Veal, D., Whiteman, M., & Hancock, J. T. (2017). Hydrogen gas and its role in cell signaling. CABI Reviews, 12, 2-3

Hydrogen gas (H2) was once thought to be inert in biological systems but it has now become apparent that exposure of a wide range of organisms, including animals and plants, to H2 or hydrogen-rich water (HRW) has beneficial effects. It is involved in... Read More about Hydrogen gas and its role in cell signaling.

Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries (2017)
Journal Article
Zafra, A., Carmona, R., Traverso, J. A., Hancock, J. T., Goldman, M. H., Claros, M. G., …Alche, J. D. (2017). Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries. Frontiers in Plant Science, 8, Article 1576. https://doi.org/10.3389/fpls.2017.01576

© 2017 Zafra, Carmona, Traverso, Hancock, Goldman, Claros, Hiscock and Alche. The olive tree is a crop of high socio-economical importance in the Mediterranean area. Sexual reproduction in this plant is an essential process, which determines the yiel... Read More about Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries.

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans (2017)
Journal Article
Floyd, K. G., Hopewell, H., Burnell, D., Hancock, J. T., Allainguillaume, J., Ladomery, M., & Wilson, I. D. (2017). Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans. Ecotoxicology, 26(7), 981-990. https://doi.org/10.1007/s10646-017-1826-z

© 2017, The Author(s). This study investigated the neurological effects of residual ground-water levels of thiaclopridon the non-target organism Caenorhabditis elegans. Nematodes treated with thiacloprid showed a dose-dependent and significantly incr... Read More about Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans.

Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola (2017)
Journal Article
Neale, H., Deshappriya, N., Arnold, D. L., Wood, M. E., Whiteman, M., & Hancock, J. T. (2017). Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola. European Journal of Plant Pathology, 149(4), 911-921. https://doi.org/10.1007/s10658-017-1240-7

© 2017, The Author(s). Hydrogen sulfide (H2S) is known to be an important signalling molecule in both animals and plants, despite its toxic nature. In plants it has been seen to control stomatal apertures, so altering the ability of bacteria to invad... Read More about Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola.

S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit (2017)
Journal Article
Silveira, N. M., Marcos, F. C., Frungillo, L., Moura, B. B., Seabra, A. B., Salgado, I., …Ribeiro, R. V. (2017). S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit. Physiologia Plantarum, 160(4), 383-395. https://doi.org/10.1111/ppl.12575

© 2017 Scandinavian Plant Physiology Society Water deficit is a major environmental constraint on crop productivity and performance and nitric oxide (NO) is an important signaling molecule associated with many biochemical and physiological processes... Read More about S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit.

Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane (2017)
Journal Article
Ribeiro, R. V., Silveira, N. M., Hancock, J. T., Frungillo, L., Siasou, E., Marcos, F. C., …Machado, E. C. (2017). Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane. Plant Physiology and Biochemistry, 115, 354-359. https://doi.org/10.1016/j.plaphy.2017.04.011

© 2017 Elsevier Masson SAS Exogenous supply of nitric oxide (NO) increases drought tolerance in sugarcane plants. However, little is known about the role of NO produced by plants under water deficit. The aim of this study was to test the hypothesis t... Read More about Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane.

Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2017)
Journal Article
Hancock, J. T. (2017). Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Frontiers in Plant Science, 8, 189. https://doi.org/10.3389/fpls.2017.00189

© 2017 Hancock. During the early periods of evolution, as well as in niche environments today, organisms have had to learn to tolerate the presence of many reactive compounds, such as reactive oxygen species, nitric oxide, and hydrogen sulfide. It is... Read More about Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Nitric oxide signalling in plants (2017)
Book Chapter
Hancock, J. T., Wilson, H. R., & Neill, S. (2017). Nitric oxide signalling in plants. In eLS. Chichester: Wiley. https://doi.org/10.1002/9780470015902.a0020109.pub2

Nitric oxide (NO) is a small simple molecule but one which is instrumental in cell signalling in a range of organisms including plants. It is a gas, often found in the form of a radical. It is produced in cells in an orchestrated manner, usually by d... Read More about Nitric oxide signalling in plants.

Competition of reactive signals and thiol modifications of proteins (2017)
Journal Article
Hancock, J. T., Craig, T. J., & Whiteman, M. (2017). Competition of reactive signals and thiol modifications of proteins. https://doi.org/10.4172/2576-1471.1000170

It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the rea... Read More about Competition of reactive signals and thiol modifications of proteins.

Cell Signalling (2016)
Book
Hancock, J. T. (2016). Cell Signalling. Oxford: Oxford University Press

4th Edition of Cell Signalling published by OUP

Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species (2016)
Journal Article
Hancock, J. T., & Whiteman, M. (2016). Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species. Annals of the New York Academy of Sciences, 1365(1), 5-14. https://doi.org/10.1111/nyas.12733

© 2016 The New York Academy of Sciences. Signaling in cells involving reactive compounds is well established. Reactive oxygen species (ROS) and nitric oxide (NO) are known to be extremely influential in the control of a range of physiological respons... Read More about Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species.