Qualitative development of a new patient reported outcome measure for underactive bladder

Uren, A; Cotterill, N; Harding, C; Hillary, C; Chapple, C; Klaver, M; Bongaerts, D; Hakimi, Z; Abrams, P

Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS) (2018)
Journal Article
Drake, M., Canham, L., Cotterill, N., Delgado, D., Homewood, J., Inglis, K., …Cottrell, D. (2018). Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS). BMC Neurology, 18(1), https://doi.org/10.1186/s12883-018-1114-4

© 2018 The Author(s). Background: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in... Read More about Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS).

Patient-centred questionnaire assessment to complement urodynamic testing (2018)
Book Chapter
Cotterill, N. Patient-centred questionnaire assessment to complement urodynamic testing. In P. Toozs-Hobson, L. Dolan, & R. Thakar (Eds.), Manual of Urodynamics for Gynaecologists. Cambridge University Press. Manuscript submitted for publication

Urodynamic assessment is undertaken with patients to provide an objective and clinical evaluation of bothersome lower urinary tract symptoms (LUTS). The use of patient-centred questionnaires alongside urodynamic evaluation is an important adjunct in... Read More about Patient-centred questionnaire assessment to complement urodynamic testing.

Progressive Multiple Sclerosis and incontinence: A survey study of the patients’ perspective on symptoms and impact (2018)
Presentation / Conference
Cotterill, N., Copestake, C., Weir, I., Drake, M., Norton, C., & Wilkins, A. (2018, May). Progressive Multiple Sclerosis and incontinence: A survey study of the patients’ perspective on symptoms and impact. Poster presented at Progressive MS Alliance Scientific Congress, Toronto, Canada

Urinary and anal incontinence associated with Progressive Multiple Sclerosis. Results of a survey study in the UK to evaluate symptoms and their impact.

Clinical Rating Scales for Urinary Symptoms in Parkinson Disease: Critique and Recommendations (2018)
Journal Article
Pavy-Le Traon, A., Shaftman, S. R., Cotterill, N., Amarenco, G., Duerr, S., Kaufmann, H., …Stebbins, G. T. (2018). Clinical Rating Scales for Urinary Symptoms in Parkinson Disease: Critique and Recommendations. Movement Disorders Clinical Practice, 5(5), 479-491. https://doi.org/10.1002/mdc3.12636

© 2018 International Parkinson and Movement Disorder Society Background: The prevalence of lower urinary tract symptoms (LUTS) is high in Parkinson's disease (PD). These problems negatively affect quality of life and include both storage and voiding... Read More about Clinical Rating Scales for Urinary Symptoms in Parkinson Disease: Critique and Recommendations.

Development and psychometric evaluation of ICIQ-PadPROM: A quality of life questionnaire to assess the treatment effect of absorbent continence products (2018)
Journal Article
Yearwood Martin, C., Murphy, C., Cotterill, N., Williams, S., Cottenden, A., & Fader, M. (2018). Development and psychometric evaluation of ICIQ-PadPROM: A quality of life questionnaire to assess the treatment effect of absorbent continence products. Neurourology and Urodynamics, 37(5), 1650-1657. https://doi.org/10.1002/nau.23389

© 2018 Wiley Periodicals, Inc. Aim: To describe the development and evaluation of the ICIQ-PadPROM, the first self-reported quality of life questionnaire to assess the treatment effect of absorbent continence products, a new addition to the set of IC... Read More about Development and psychometric evaluation of ICIQ-PadPROM: A quality of life questionnaire to assess the treatment effect of absorbent continence products.

Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial (2018)
Journal Article
Constable, L., Cotterill, N., Cooper, D., Glazener, C., Drake, M. J., Forrest, M., …Abrams, P. (2018). Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2501-2

© 2018 The Author(s). Background: Stress urinary incontinence (SUI) is a frequent adverse effect for men undergoing prostate surgery. A large proportion (around 8% after radical prostatectomy and 2% after transurethral resection of prostate (TURP)) a... Read More about Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial.

Development of a core set of outcome measures for OAB treatment (2017)
Journal Article
Foust-Wright, C., Wissig, S., Stowell, C., Olson, E., Anderson, A., Anger, J., …Milsom, I. (2017). Development of a core set of outcome measures for OAB treatment. International Urogynecology Journal, 28(12), 1785-1793. https://doi.org/10.1007/s00192-017-3481-6

© 2017, The Author(s). Introduction and hypothesis: Standardized measures enable the comparison of outcomes across providers and treatments giving valuable information for improving care quality and efficacy. The aim of this project was to define a m... Read More about Development of a core set of outcome measures for OAB treatment.

Participant’s experiences of taking melatonin for the treatment of nocturia in MS: Qualitative findings from a double blind RCT (2017)
Presentation / Conference
Khan, R., Uren, A., Homewood, J., Inglis, K., Johnson, L., Owen, D., …Cotterill, N. (2017, September). Participant’s experiences of taking melatonin for the treatment of nocturia in MS: Qualitative findings from a double blind RCT

Multiple Sclerosis (MS) is a chronic neurological disorder caused by eventual neurodegeneration within the central nervous system resulting in impaired physical, cognitive and psychological functioning. It is often progressive and can result in many... Read More about Participant’s experiences of taking melatonin for the treatment of nocturia in MS: Qualitative findings from a double blind RCT.

Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013 (2017)
Journal Article
Cotterill, N., Madersbacher, H., Wyndaele, J. J., Apostolidis, A., Drake, M. J., Gajewski, J., …Emmanuel, A. (2018). Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013. Neurourology and Urodynamics, 37(1), 46-53. https://doi.org/10.1002/nau.23289

© 2017 Wiley Periodicals, Inc. Background: Evidence-based guidelines for the management of neurological disease and lower bowel dysfunction have been produced by the International Consultations on Incontinence (ICI). These are comprehensive guideline... Read More about Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013.

Patient-reported outcome assessment (2017)
Book Chapter
Castro-Diaz, D., Robinson, D., Bosch, R., Costantini, E., Cotterill, N., Espuna-Pons, M., …Yoshida, M. (2017). Patient-reported outcome assessment. In P. Abrams, L. Cardozo, A. Wagg, & A. Wein (Eds.), Incontinence: Proceedings of the Sixth International Consultation on Incontinence, Tokyo (541-598). Health Publications Limited

Tri-ennial review of the literature related to patient-reported outcome assessment.

Adapting the QuinteT Recruitment Intervention (QRI) to optimise recruitment in an ongoing randomised controlled trial (2017)
Presentation / Conference
Jepson, M., Donovan, J., Khan, R., Cotterill, N., Abrams, P., & Norrie, J. (2017, May). Adapting the QuinteT Recruitment Intervention (QRI) to optimise recruitment in an ongoing randomised controlled trial. Presented at International Clinical Trials Methodology Conference 2017, Liverpool, UK

Randomised Controlled Trials (RCTs) are the most rigorous study design to evaluate healthcare interventions. However, their success relies on patient recruitment. The QuinteT Recruitment Intervention (QRI) aims to address recruitment difficulties an... Read More about Adapting the QuinteT Recruitment Intervention (QRI) to optimise recruitment in an ongoing randomised controlled trial.

A randomised controlled trial to determine the clinical and cost effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP) versus transurethral resection of the prostate (TURP) in the National Health Service (NHS) - the UNBLOCS trial: A study protocol for a randomised controlled trial (2017)
Journal Article
Swami, K. S., Noble, S. M., Brookes, S. T., Worthington, J., Taylor, H., Abrams, P., …Hashim, H. (2017). A randomised controlled trial to determine the clinical and cost effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP) versus transurethral resection of the prostate (TURP) in the National Health Service (NHS) - the UNBLOCS trial: A study protocol for a randomised controlled trial. Trials, 18(1), https://doi.org/10.1186/s13063-017-1916-5

© 2017 The Author(s). Background: Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely un... Read More about A randomised controlled trial to determine the clinical and cost effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP) versus transurethral resection of the prostate (TURP) in the National Health Service (NHS) - the UNBLOCS trial: A study protocol for a randomised controlled trial.

Qualitative Exploration of the Patient Experience of Underactive Bladder (2017)
Journal Article
Uren, A. D., Cotterill, N., Harding, C., Hillary, C., Chapple, C., Klaver, M., …Abrams, P. (2017). Qualitative Exploration of the Patient Experience of Underactive Bladder. European Urology, 72(3), 402-407. https://doi.org/10.1016/j.eururo.2017.03.045

© 2017 European Association of Urology Background Underactive bladder (UAB) is considered the symptom complex associated with the urodynamic diagnosis of detrusor underactivity. Objective The aim of this research was to investigate the patient report... Read More about Qualitative Exploration of the Patient Experience of Underactive Bladder.

Can a patient reported outcome be adequate without assessing quality of life in lower urinary tract dysfunction? (2017)
Journal Article
Cotterill, N., & Tubaro, A. (2017). Can a patient reported outcome be adequate without assessing quality of life in lower urinary tract dysfunction?. Neurourology and Urodynamics, 36(4), 943-948. https://doi.org/10.1002/nau.23177

© 2017 Wiley Periodicals, Inc. AIMS AND METHODS: A think tank was convened at the sixth ICI-RS meeting held in the United Kingdom on September 2015, to consider the adequacy of patient reported outcome (PRO) measurement if quality of life (QoL) evalu... Read More about Can a patient reported outcome be adequate without assessing quality of life in lower urinary tract dysfunction?.

Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS) (2017)
Journal Article
Delgado, D., Canham, L., Cotterill, N., Cottrell, D., Drake, M. J., Inglis, K., …White, P. (2017). Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS). BMC Neurology, 17(1), https://doi.org/10.1186/s12883-017-0845-y

© 2017 The Author(s). Background: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacit... Read More about Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS).

Consultant outcome publication: Surgeons' opinions of a new mandatory health policy (2017)
Presentation / Conference
Williams, M., Cotterill, N., Drake, M., & Keeley, F. (2017, March). Consultant outcome publication: Surgeons' opinions of a new mandatory health policy. Poster presented at European Association of Urology Annual Meeting 2017, London, UK

Consultant Outcome Publication (COP) regarding outcomes of operations done by individual surgeons was introduced to UK Urology in 2012 with the first publication of the Nephrectomy Outcomes Database. COP was championed as a policy to increase transpa... Read More about Consultant outcome publication: Surgeons' opinions of a new mandatory health policy.

Bladder diary and symptom scores (2016)
Book Chapter
Uren, A., & Cotterill, N. (2016). Bladder diary and symptom scores. In D. Staskin, & L. Cardozo (Eds.), Textbook of Female Urology and Urogynecology. Informa Healthcare

A summary of the use of bladder diaries and symptom scores for the evaluation of lower urinary tract symptoms.

International consultation on incontinence modular questionnaire (2016)
Book Chapter
Cotterill, N., & Abrams, P. (2016). International consultation on incontinence modular questionnaire. In D. Staskin, & L. Cardozo (Eds.), Textbook of Female Urology and Urogynecology. CRC Press

A summary of the International Consultation on Incontinence Modular Questionnaire and its use in female urology and urogynaecology.

Validated constipation symptom and quality-of-life measures neither reflect patient and clinician concerns nor use words familiar to patients (2016)
Journal Article
Scott, M., Dimidi, E., Dibley, L., Cotterill, N., Scott, S., Whelan, K., …Norton, C. (2016). Validated constipation symptom and quality-of-life measures neither reflect patient and clinician concerns nor use words familiar to patients. Gastrointestinal Nursing, 14(8), 29-38. https://doi.org/10.12968/gasn.2016.14.8.29

© MA Healthcare Ltd. Patients' self-reported constipation symptoms, preferred terminology and quality of life (QoL) issues were explored through 14 semi-structured and five unstructured interviews. In a modified Delphi study, 11 clinicians rated the... Read More about Validated constipation symptom and quality-of-life measures neither reflect patient and clinician concerns nor use words familiar to patients.

Qualitative development of a new patient reported outcome measure for underactive bladder (2016)
Presentation / Conference
Uren, A., Cotterill, N., Harding, C., Hillary, C., Chapple, C., Klaver, M., …Abrams, P. (2016, September). Qualitative development of a new patient reported outcome measure for underactive bladder. Poster presented at International Continence Society Annual Meeting 2016, Tokyo, Japan

Hypothesis / aims of study The patient experience of underactive bladder (UAB) was explored, for the purpose of developing a Patient Reported Outcome (PRO) measure to assess the symptoms and impact of the condition. UAB is currently proposed as the... Read More about Qualitative development of a new patient reported outcome measure for underactive bladder.

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