All Outputs (3)

Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses (2023)
Thesis
Visser, H. Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10014381

Confronted with DNA damage, cells can undergo cell cycle arrest and DNA repair, or cell death. However, communal DNA damage response (DDR) proteins involved in each of these cell fates, has confounded attempts to unravel the molecular nuances that dr... Read More about Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses.

MicroRNAs and the DNA damage response: How is cell fate determined? (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs and the DNA damage response: How is cell fate determined?. DNA Repair, 108, Article 103245. https://doi.org/10.1016/j.dnarep.2021.103245

It is becoming clear that the DNA damage response orchestrates an appropriate response to a given level of DNA damage, whether that is cell cycle arrest and repair, senescence or apoptosis. It is plausible that the alternative regulation of the DNA d... Read More about MicroRNAs and the DNA damage response: How is cell fate determined?.

MicroRNAs, damage levels, and DNA damage response control (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs, damage levels, and DNA damage response control. Trends in Genetics, 37(11), 963-965. https://doi.org/10.1016/j.tig.2021.06.018

DNA damage–inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modul... Read More about MicroRNAs, damage levels, and DNA damage response control.