Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins
(2022)
Journal Article
Maqsood, Z., Clark, J. C., Martin, E. M., Cheung, Y. F. H., Morán, L. A., Watson, S. E. T., …Watson, S. P. (2022). Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. PLoS Computational Biology, 18(11), Article e1010708. https://doi.org/10.1371/journal.pcbi.1010708
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom... Read More about Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.