Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice
(2019)
Journal Article
Evans, C. E., Thomas, R. S., Freeman, T. J., Hvoslef-Eide, M., Good, M. A., & Kidd, E. J. (2019). Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiology of Aging, 75, 136-149. https://doi.org/10.1016/j.neurobiolaging.2018.11.011
β-Amyloid (Aβ) accumulation is an early event of Alzheimer's disease (AD) pathogenesis. Inhibition of Aβ production by β-secretase (BACE) has been proposed as a potential therapeutic strategy for AD. However, BACE inhibitors lack specificity and have... Read More about Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.