All Outputs (3)

A two-state model for the kinetics of competitive radioligand binding (2018)
Journal Article
Guo, D., Peletier, L. A., Bridge, L., Keur, W., de Vries, H., Zweemer, A., …Ijzerman, A. P. (2018). A two-state model for the kinetics of competitive radioligand binding. British Journal of Pharmacology, 175(10), 1719-1730. https://doi.org/10.1111/bph.14184

© 2018 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and Purpose: Ligand–receptor binding kinetics is receiving increasing attention in the drug research co... Read More about A two-state model for the kinetics of competitive radioligand binding.

Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions (2018)
Journal Article
White, C., & Bridge, L. (2019). Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions. Bulletin of Mathematical Biology, 81(9), 3542-3574. https://doi.org/10.1007/s11538-017-0387-x

Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of lig... Read More about Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions.

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor (2018)
Journal Article
Bridge, L., Mead, J., Frattini, E., Winfield, I., & Ladds, G. (2018). Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. Journal of Theoretical Biology, 442, 44-65. https://doi.org/10.1016/j.jtbi.2018.01.010

© 2018 The Authors Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely been... Read More about Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.