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All Outputs (3)

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ) (2016)
Journal Article
Wills, J. W., Hondow, N., Thomas, A. D., Chapman, K. E., Fish, D., Maffeis, T. G., …Doak, S. H. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ). Particle and Fibre Toxicology, 13, Article 50. https://doi.org/10.1186/s12989-016-0161-5

© 2016 The Author(s). Background: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirabl... Read More about Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ).

DNA Repair and its influence on points of departure for alkylating agent genotoxicity (2016)
Book Chapter
Thomas, A. D., & Johnson, G. (2016). DNA Repair and its influence on points of departure for alkylating agent genotoxicity. In S. Fukushima, & T. Nohmi (Eds.), Thresholds of Genotoxic Carcinogens From Mechanisms to Regulation (67-82). London: Academic Press

Answering the question of whether low doses of DNA-reactive genotoxicants are of negligible concern has become a global effort due to its central importance in human health risk assessments. As a result, a huge amount of data exists suggesting that l... Read More about DNA Repair and its influence on points of departure for alkylating agent genotoxicity.

DNA damage and the balance between survival and death in cancer biology (2016)
Journal Article
Roos, W. P., Thomas, A. D., & Kaina, B. (2016). DNA damage and the balance between survival and death in cancer biology. Nature Reviews Cancer, 16(1), 20-33. https://doi.org/10.1038/nrc.2015.2

© 2016 Macmillan Publishers Limited. DNA is vulnerable to damage resulting from endogenous metabolites, environmental and dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics. Cells respond to DNA damage by activating... Read More about DNA damage and the balance between survival and death in cancer biology.