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The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells (2015)
Journal Article
Qualtrough, D., Rees, P., Speight, B., Williams, A. C., & Paraskeva, C. (2015). The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells. Cancers, 7(3), 1885-1899. https://doi.org/10.3390/cancers7030867

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Colorectal cancer is a major global health problem resulting in over 600,000 deaths world-wide every year with the majority of these due to metastatic disease. Wnt signalling, and more specifi... Read More about The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells.

The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis (2015)
Journal Article
Qualtrough, D., & Flemban, A. (2015). The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis. Cancers, 7(3), 1863-1884. https://doi.org/10.3390/cancers7030866

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells betwee... Read More about The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis.