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Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl (2014)
Journal Article
Chapman, K., Thomas, A. D., Wills, J., Pfuhler, S., Doak, S. H., & Jenkins, G. J. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl. Mutagenesis, 29(3), 165-175. https://doi.org/10.1093/mutage/geu011

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive... Read More about Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl.

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells (2014)
Journal Article
Jenkins, G. J., Johnson, G. E., Doak, S. H., Doherty, A. T., Scott, A. D., Chapman, K. E., …Thomas, A. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164. https://doi.org/10.1093/mutage/geu008

Micronucleus (MN) induction is an established cytogenetic end point for evaluating structural and numerical chromosomal alterations in genotoxicity testing. A semi-automated scoring protocol for the assessment of MN preparations from human cell lines... Read More about Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.