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24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation (2014)
Journal Article
Lancaster, S. T., Blackburn, J., Blom, A., Makishima, M., Ishizawa, M., & Mansell, J. (2014). 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation. Steroids, 83, 52-61. https://doi.org/10.1016/j.steroids.2014.01.010

Vitamin D receptor (VDR) agonists supporting human osteoblast (hOB) differentiation in the absence of bone resorption are attractive agents in a bone regenerative setting. One potential candidate fulfilling these roles is 24,25-dihydroxy vitamin D3 (... Read More about 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation.

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article
Blackburn, J., Burston, B., Shepherd, S., Bone, H., Blom, A., & Mansell, J. (2014). Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.