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A mitotic role for BRCA1/BARD1 in tumor suppression? (2006)
Journal Article
Clarke, P. R., & Sanderson, H. S. (2006). A mitotic role for BRCA1/BARD1 in tumor suppression?. Cell, 127(3), 453-455. https://doi.org/10.1016/j.cell.2006.10.020

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase... Read More about A mitotic role for BRCA1/BARD1 in tumor suppression?.

Cell biology: Ran, mitosis and the cancer connection (2006)
Journal Article
Sanderson, H. S., & Clarke, P. R. (2006). Cell biology: Ran, mitosis and the cancer connection. Current Biology, 16(12), PR466-R468. https://doi.org/10.1016/j.cub.2006.05.032

The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer. © 2006 Elsevier Ltd. All rights... Read More about Cell biology: Ran, mitosis and the cancer connection.

Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export (2006)
Journal Article
Fornerod, M., Bernad, R., Engelsma, D., Sanderson, H., Pickersgill, H., & Fornerod, . M. (2006). Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export. Journal of Biological Chemistry, 281(28), 19378-19386. https://doi.org/10.1074/jbc.M512585200

The nuclear pore complex (NPC) conducts macromolecular transport to and from the nucleus and provides a kinetic/hydrophobic barrier composed of phenylalanine-glycine (FG) repeats. Nuclear transport is achieved through permeation of this barrier by tr... Read More about Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.

High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis (2006)
Journal Article
Drummond, S. P., Rutherford, S. A., Sanderson, H. S., & Allen, T. D. (2006). High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis. Canadian Journal of Physiology and Pharmacology, 84(3-4), 423-430. https://doi.org/10.1139/y05-148

Nuclear pore complexes (NPCs) are the gateways for both active and passive bidirectional molecular transport between the nucleoplasm and cytoplasm. These mega-dalton assemblies are composed of multiple copies of approximately 30 distinct proteins ter... Read More about High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis.