Skip to main content

Research Repository

Advanced Search

All Outputs (1)

Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin (2005)
Journal Article
Yennawar, N., Goto, M., Miyahara, I., Hirotsu, K., Conway, M., Islam, M. M., & Hutson, S. M. (2005). Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. Journal of Biological Chemistry, 280(44), 37246-37256. https://doi.org/10.1074/jbc.M506486200

This study presents the first three-dimensional structures of human cytosolic branched-chain aminotransferase (hBCATc) isozyme complexed with the neuroactive drug gabapentin, the hBCATc Michaelis complex with the substrate analog, 4-methylvalerate, a... Read More about Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.