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Development of an electrochemical assay for 2,6-dinitrotoluene, based on a screen-printed carbon electrode, and its potential application in bioanalysis, occupational and public health (2003)
Journal Article
Ratcliffe, N. M., Hawkins, S. J., Pritchard, P. R., Hart, J. P., & Honeychurch, K. C. (2003). Development of an electrochemical assay for 2,6-dinitrotoluene, based on a screen-printed carbon electrode, and its potential application in bioanalysis, occupational and public health. Biosensors and Bioelectronics, 19(4), 305-312. https://doi.org/10.1016/S0956-5663%2803%2900208-2

Screen-printed carbon electrodes (SPCEs) have been successfully exploited as disposable sensors for the measurement of 2,6-dinitrotoluene (2,6-DNT) using a stripping voltammetric method. Initial investigations were undertaken using cyclic voltammetry... Read More about Development of an electrochemical assay for 2,6-dinitrotoluene, based on a screen-printed carbon electrode, and its potential application in bioanalysis, occupational and public health.

Oxidative stress signalling (2003)
Book Chapter
Desikan, R., Hancock, J. T., & Neill, S. (2003). Oxidative stress signalling. In H. Hirt, & K. Shinozaki (Eds.), Plant Responses to Abiotic Stress (121-150). Springer-Verlag

Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom (2003)
Journal Article
Shaw, M. W., Wilkinson, M. J., Elliott, L. J., Allainguillaume, J., Norris, C., Welters, R., …Mason, D. C. (2003). Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom. Science, 302(5644), 457-459. https://doi.org/10.1126/science.1088200

Measures blocking hybridization would prevent or reduce biotic or environmental change caused by gene flow from genetically modified (GM) crops to wild relatives. The efficacy of any such measure depends on hybrid numbers within the legislative regio... Read More about Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom.

Principles of cell signalling (2003)
Book Chapter
Hancock, J. T. (2003). Principles of cell signalling. In S. Kumar, & P. Bentley (Eds.), On Growth, Form and Computers. Elsevier

Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer (2003)
Journal Article
Sivakumar, R., Elder, J., Greenhough, A., Lacy-Colson, J., Jones, P., Hall, C., …Elder, J. (2003). Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer. European Journal of Cancer, 1(5), S84. https://doi.org/10.1016/S1359-6349%2803%2990306-5

Background: Stabilisation and nuclear translocation of beta-catenin are suggested to be the early events in the colorectal carcinogenesis. Nuclear accumulation of beta-catenin was associated with high-grade tumour and increased cell proliferation in... Read More about Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer.

Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis (2003)
Journal Article
Hastie, N. D., Fleming, S., Patek, C. E., Miles, C. G., Bellamy, C. O., Ladomery, M., …Hooper, M. L. (2003). Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis. Human Molecular Genetics, 12(18), 2379-2394. https://doi.org/10.1093/hmg/ddg240

Denys-Drash syndrome (DDS) is caused by dominant mutations of the Wilms' tumour suppressor gene, WT1, and characterized by a nephropathy involving diffuse mesangial sclerosis, male pseudohermaphroditism and/ or Wilms' tumourigenesis. Previously, we r... Read More about Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.

British newspapers priviledge health and medicine topics over other science news (2003)
Journal Article
Weitkamp, E. (2003). British newspapers priviledge health and medicine topics over other science news. Public Relations Review, 29(3), 321-333. https://doi.org/10.1016/S0363-8111%2803%2900041-9

This study examines coverage of science, health and medicine in five UK national newspapers: three broadsheets, a mid-sheet and a tabloid. The content analysis is compared with a quantitative survey of members of the Association of British Science Wr... Read More about British newspapers priviledge health and medicine topics over other science news.

The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties (2003)
Journal Article
de Lacy Costello, B., Ratcliffe, N. M., & Sivanand, P. S. (2003). The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties. Synthetic Metals, 139(1), 43-55. https://doi.org/10.1016/S0379-6779%2802%2901247-X

Novel 3-substituted pyrrole monomers possessing chiral side groups were synthesised. These compounds were successfully polymerised with ferric salts and the polymer materials fabricated into sensors. The sensors were found to elicit differential chan... Read More about The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties.

Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection (2003)
Journal Article
McCalley, D. V. (2003). Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection. Analytical Chemistry, 75(14), 3404-3410. https://doi.org/10.1021/ac020715f

The retention and overloading behavior of some basic (and acidic) compounds has been studied on different RP-HPLC columns in buffers of varying ionic strength. Anomalous retention patterns of acids and bases were found on one phase in low-pH, volatil... Read More about Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection.

Experimental reaction-diffusion chemical processors for robot path planning (2003)
Journal Article
Adamatzky, A., de Lacy Costello, B., Ratcliffe, N. M., & Melhuish, C. (2003). Experimental reaction-diffusion chemical processors for robot path planning. Journal of Intelligent and Robotic Systems, 37(3), 233-249. https://doi.org/10.1023/A%3A1025414424756

In this paper we discuss the experimental implementation of a chemical reaction-diffusion processor for robot motion planning in terms of finding the shortest collision-free path for a robot moving in an arena with obstacles. These reaction-diffusion... Read More about Experimental reaction-diffusion chemical processors for robot path planning.

Thick film organic vapour sensors based on binary mixtures of metal oxides (2003)
Journal Article
Ewen, R. J., de Lacy Costello, B., Ratcliffe, N. M., & Sivanand, P. S. (2003). Thick film organic vapour sensors based on binary mixtures of metal oxides. Sensors and Actuators B: Chemical, 92(1-2), 159-166. https://doi.org/10.1016/S0925-4005%2803%2900258-2

Previously, composite sensors incorporating differing proportions of tin dioxide and zinc oxide were reported which exhibited high sensitivity to a range of organic vapours under dry conditions (0% relative humidity, RH). Most importantly, the compos... Read More about Thick film organic vapour sensors based on binary mixtures of metal oxides.

Nitric oxide signalling in plants (2003)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2003). Nitric oxide signalling in plants. New Phytologist, 159(1), 11-35. https://doi.org/10.1046/j.1469-8137.2003.00804.x

Recently nitric oxide (NO) has emerged as a key signalling molecule in plants. Here we review the potential sources of endogenous NO, outline the biological processes likely to be mediated by NO, and discuss the downstream signalling processes by whi... Read More about Nitric oxide signalling in plants.

Bioko biodiversity awareness campaign report to conservation international (2003)
Report
Fernández, D. (2003). Bioko biodiversity awareness campaign report to conservation international

Report to Conservation International on the 4-day, island-wide awareness campaign for government officials and village chiefs on the laws regulating Bioko Island’s protected areas

Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one (2003)
Journal Article
Ladomery, M., Sommerville, J., Woolner, S., Slight, J., & Hastie, N. (2003). Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one. Journal of Cell Science, 116(8), 1539-1549. https://doi.org/10.1242/jcs.00324

The Wilms' tumour suppressor gene WT1 encodes a protein involved in urogenital development and disease. The salient feature of WT1 is the presence of four 'Krüppel'-type C2-H2 zinc fingers in the C-terminus. Uniquely to WTI, an evolutionarily conserv... Read More about Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one.

Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines (2003)
Journal Article
Yennawar, N., Conway, M. E., Wallin, R., Poole, L. B., & Hutson, S. M. (2003). Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines. BBA - Proteins and Proteomics, 1647(1-2), 61-65. https://doi.org/10.1016/S1570-9639%2803%2900051-7

Crystal structures of the fold type IV pyridoxal phosphate (PLP)-dependent human mitochondrial branched chain aminotransferase (hBCATm) reaction intermediates have provided a structural explanation for the kinetically determined substrate specificity... Read More about Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines.