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Molecular mechanisms conferring resistance/sensitivity to glucocorticoid-induced apoptosis
Book Chapter
Berrou, I., Krstic-Demonacos, M., & Demonacos, C. Molecular mechanisms conferring resistance/sensitivity to glucocorticoid-induced apoptosis. In X. Xiaoxi Qian (Ed.), Glucocorticoids - New Recognition of Our Familiar FriendIntechOpen. https://doi.org/10.5772/51467

Resistance to glucocorticoid induced apoptosis in acute lymphoblastic leukaemia (ALL) has been attributed to several different processes and pathways including predominance of certain GR isoforms with reduced transcriptional activity, either due to a... Read More about Molecular mechanisms conferring resistance/sensitivity to glucocorticoid-induced apoptosis.

ROS & energy production pathways in the determination of resistance/sensitivity to glucocorticoids-induced apoptosis in acute lymphoblastic leukaemia
Thesis
Berrou, I. ROS & energy production pathways in the determination of resistance/sensitivity to glucocorticoids-induced apoptosis in acute lymphoblastic leukaemia. (Thesis). The University of Manchester

Glucocorticoids have long been used in the treatment of acute lymphoblastic leukaemia due to their ability to cause cell cycle arrest and apoptosis of lymphoid cells. However, some patients do not respond to glucocorticoid treatment and the majority,... Read More about ROS & energy production pathways in the determination of resistance/sensitivity to glucocorticoids-induced apoptosis in acute lymphoblastic leukaemia.