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All Outputs (12)

The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean (2020)
Thesis
Meek, S. The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6442771

Seagrass meadows are vital coastal habitats that support a wide array of species and provide numerous ecosystem services. The area of seagrass meadow has declined significantly, at a rate of about 5% per year, since 1980. Emerging techniques for seag... Read More about The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean.

Vaccine movements on social media: A visual and network analysis (2020)
Thesis
Milani, E. Vaccine movements on social media: A visual and network analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/5936098

Vaccines are considered one of the most effective public health interventions, but they have been subject to opposition since they were first proposed. Anti-vaccine activists disseminate and sensationalise objections to vaccinations through various c... Read More about Vaccine movements on social media: A visual and network analysis.

Interaction between leukaemic cells and the bone marrow stroma (2020)
Thesis
Gynn, L. Interaction between leukaemic cells and the bone marrow stroma. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6037712

Mesenchymal stromal cells (MSC) enhance growth and protect leukaemic cells from drug-induced toxicity in the bone marrow microenvironment (BMM), however, these interactions are not fully understood and less is known about the impact of leukaemic cell... Read More about Interaction between leukaemic cells and the bone marrow stroma.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis
Shafei, M. The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3429539

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers (2020)
Thesis
Hudd, F. Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3566872

Introduction: There currently is an unmet need for new diagnostics to monitor Alzheimer’s disease (AD) and a lack of understanding of the metabolic processes, in particular leucine deprivation on disease and the autophagy pathway. It is thought that... Read More about Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers.

Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways (2020)
Thesis
Okoro, G. U. Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491050

Introduction and aims: Alzheimer’s disease (AD) has for decades been associated with increased accumulation of brain amyloid β peptides (Aβ) and phosphorylated tau. Unfortunately, targeted therapy to Aβ in particular has not been successful resulting... Read More about Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars (2020)
Thesis
Nicholas, P. Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490862

The aim of the studies described in this thesis was to develop a set of single shot biosensors, for low concentration measures (less the 1 mM) of glucose, sucrose and fructose. In addition, the development of a user friendly potentiostat instrumental... Read More about Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars.

Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome (2020)
Thesis
Bennett, S. Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/4522950

Abstract Introduction: Joint Hypermobility Syndrome (JHS) and Ehlers-Danlos Syndrome Hypermobility Type (EDS-HT) are heritable disorders affecting connective tissue. Existing research has predominately focused on biological features such as joint... Read More about Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome.

In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.

Targeting the splice factor kinase CLK1 in prostate cancer cells (2020)
Thesis
Uzor, S. O. Targeting the splice factor kinase CLK1 in prostate cancer cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490733

Prostate cancer is the most rampant diagnosed cancer and the second leading cause of cancer related death in men between middle age and old age. There is a need to identify the molecular genetic processes that underpin prostate cancer and to search f... Read More about Targeting the splice factor kinase CLK1 in prostate cancer cells.

Antimicrobial activity of essential oils as liquid and vapour applications (2020)
Thesis
Elcocks, E. R. (2020). Antimicrobial activity of essential oils as liquid and vapour applications. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490727

Essential oils produced by plants have been used as antimicrobial agents historically, however, many essential oils remain under-exploited as alternatives to antimicrobials. Therefore, the aim of this thesis was to evaluate the antibacterial efficacy... Read More about Antimicrobial activity of essential oils as liquid and vapour applications.