All Outputs (19)

How hydrogen (H2) can support food security: From farm to fork (2024)
Journal Article
Russell, G., Nenov, A., & Hancock, J. T. (2024). How hydrogen (H2) can support food security: From farm to fork. Applied Sciences, 14(7), 2877. https://doi.org/10.3390/app14072877

Molecular hydrogen (H2) is a low-molecular-weight, non-polar and electrochemically neutral substance that acts as an effective antioxidant and cytoprotective agent, with research into the effects of H2 incorporation into the food chain, at various st... Read More about How hydrogen (H2) can support food security: From farm to fork.

An interplay of gases: oxygen and hydrogen in biological systems (2024)
Journal Article
Russell, G., May, J., & Hancock, J. T. (2024). An interplay of gases: oxygen and hydrogen in biological systems. Oxygen, 4(1), 37-52. https://doi.org/10.3390/oxygen4010003

Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H2) play... Read More about An interplay of gases: oxygen and hydrogen in biological systems.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

The effects of molecular hydrogen therapies on fertility (2023)
Journal Article
Russell, G., & Nenov, A. (2023). The effects of molecular hydrogen therapies on fertility. SciBase Clinical and Medical Case Reports, 1(1), 1001. https://doi.org/10.52768/casereports/1001

Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples, families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents oft... Read More about The effects of molecular hydrogen therapies on fertility.

Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot (2023)
Journal Article
Alwazeer, D., Allam Elnasanelkasim, M., Çiğdem, A., ‎Engin, T., Kanmaz, H., Adnan Hayaloglu, A., …Hancock, J. T. (in press). Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot. Industrial Crops and Products,

Different methods are used for extracting phytochemicals from plant produce. Some ‎methods require sophisticated and expensive instruments, while others need multiple steps ‎and specialist equipment, leading to an increase in energy, solvents, cost,... Read More about Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article
Hancock, J. T., Russell, G., & Stratakos, A. (2022). Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry. Applied Sciences, 12(20), Article 10448. https://doi.org/10.3390/app122010448

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

Recent advances in the application of essential oils as potential therapeutic candidates for Candida-related infections (2022)
Journal Article
Tran, H., Udoh, S., Russell, G., Okeyoyin, O. R., Aftab, S., Rodriguez, I., …Adukwu, E. C. (in press). Recent advances in the application of essential oils as potential therapeutic candidates for Candida-related infections. Applied Microbiology, 2(2), 397-413. https://doi.org/10.3390/applmicrobiol2020030

Candidiasis (oral, vulvovaginal, or systemic bloodstream infections) are important human fungal infections associated with a high global prevalence in otherwise healthy adults but are also opportunistic infections in immunocompromised patients. With... Read More about Recent advances in the application of essential oils as potential therapeutic candidates for Candida-related infections.

How are turmeric and its derivative products beneficial for intestinal health? (2022)
Journal Article
Russell, G., Rolfe, V., & Adukwu, E. (2022). How are turmeric and its derivative products beneficial for intestinal health?. Modern Journal of Medicine and Biology, 1(2),

Turmeric is the common name for the rhizome of Curcuma longa L., and has been used as a curative and digestive aide in both Chinese and Indian traditional medicine since ancient times. Investigations into the physiological actions of this particular... Read More about How are turmeric and its derivative products beneficial for intestinal health?.

Molecular hydrogen as medicine: An assessment of administration methods (2021)
Journal Article
Russell, G., Nenov, A., Kisher, H., & Hancock, J. T. (2021). Molecular hydrogen as medicine: An assessment of administration methods. Hydrogen, 2(4), 444-460. https://doi.org/10.3390/hydrogen2040025

Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is g... Read More about Molecular hydrogen as medicine: An assessment of administration methods.

Molecular hydrogen: Is this a viable new treatment for plants in the UK? (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., & Russell, G. (2021). Molecular hydrogen: Is this a viable new treatment for plants in the UK?. Plants, 10(11), Article 2270

Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and postharvest storage of crops has yet to be widely accepted in the UK. The evidence continues to grow that treatment of plants and pl... Read More about Molecular hydrogen: Is this a viable new treatment for plants in the UK?.

Molecular hydrogen in agriculture (2021)
Journal Article
Zulfiqar, F., Russell, G., & Hancock, J. T. (2021). Molecular hydrogen in agriculture. Planta, 254(3), Article 56. https://doi.org/10.1007/s00425-021-03706-0

Main conclusion: H2 gas, usually in the form of H2-saturated water, could play a useful role in improving many aspects of plant growth and productivity, including resistance to stress tolerance and improved post-harvest durability. Therefore, molecul... Read More about Molecular hydrogen in agriculture.

Molecular hydrogen: Redox reactions and possible biological interactions (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., & Russell, G. (2021). Molecular hydrogen: Redox reactions and possible biological interactions. Reactive Oxygen Species, 11, m17–m25. https://doi.org/10.20455/ros.2021.m.803

Molecular hydrogen (H2), either as a gas or as hydrogen-rich water (HRW), is suggested to be a useful treatment for a range of human diseases and also to improve agricultural output. It is often posited that H2 accomplishes its biological action, in... Read More about Molecular hydrogen: Redox reactions and possible biological interactions.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (2021). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal, May 2021, https://doi.org/10.33590/emj/21-00027

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), Article 367. https://doi.org/10.3390/plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.

Hydrogenases and the role of molecular hydrogen in plants (2020)
Journal Article
Russell, G., Zulfiqar, F., & Hancock, J. T. (2020). Hydrogenases and the role of molecular hydrogen in plants. Plants, 9(9), 1-15. https://doi.org/10.3390/plants9091136

Molecular hydrogen (H2) has been suggested to be a beneficial treatment for a range of species, from humans to plants. Hydrogenases catalyze the reversible oxidation of H2, and are found in many organisms, including plants. One of the cellular effect... Read More about Hydrogenases and the role of molecular hydrogen in plants.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2020)
Journal Article
Russell, G., Veal, D., & Hancock, J. T. (2020). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species, 9(26), 48-69

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.