All Outputs (3)

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer (2020)
Journal Article
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., …Relton, C. L. (2021). A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention, 30(3), 564-575. https://doi.org/10.1158/1055-9965.EPI-20-1176

Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new... Read More about A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer.

A Wnt-BMP4 signaling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma (2020)
Journal Article
Szemes, M., Melegh, Z., Bellamy, J., Greenhough, A., Kollareddy, M., Catchpoole, D., & Malik, K. (2020). A Wnt-BMP4 signaling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma. Cells, 9(3), Article 783. https://doi.org/10.3390/cells9030783

The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system. Surprisingly, their role in paediatric neuroblastoma, the prototypic tumor... Read More about A Wnt-BMP4 signaling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma.

BCL–3 promotes cyclooxygenase–2/prostaglandin E2 signalling in colorectal cancer (2020)
Journal Article
Collard, T. J., Fallatah, H. M., Greenhough, A., Paraskeva, C., & Williams, A. C. (2020). BCL–3 promotes cyclooxygenase–2/prostaglandin E2 signalling in colorectal cancer. International Journal of Oncology, 56(5), 1304-1313. https://doi.org/10.3892/ijo.2020.5013

First discovered as an oncogene in leukaemia, recent reports highlight an emerging role for the proto-oncogene BCL-3 in solid tumours. Importantly, BCL-3 expression is upregulated in >30% of colorectal cancer cases and is reported to be associated wi... Read More about BCL–3 promotes cyclooxygenase–2/prostaglandin E2 signalling in colorectal cancer.