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Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies (2012)
Journal Article
Elmehdawi, F., Wheway, G., Szymanska, K., Adams, M., High, A. S., Johnson, C. A., & Robinson, P. A. (2013). Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies. Experimental Cell Research, 319(3), 161-172. https://doi.org/10.1016/j.yexcr.2012.10.002

HHARI (also known as ARIH1) is an ubiquitin-protein ligase and is the cognate of the E2, UbcH7 (UBE2L3). To establish a functional role for HHARI in cellular proliferation processes, we performed a reverse genetics screen that identified n=86/522 (16... Read More about Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.

A meckelin-filamin a interaction mediates ciliogenesis (2012)
Journal Article
Adams, M., Simms, R. J., Abdelhamed, Z., Dawe, H. R., Szymanska, K., Logan, C. V., …Johnson, C. A. (2012). A meckelin-filamin a interaction mediates ciliogenesis. Human Molecular Genetics, 21(6), 1272-1286. https://doi.org/10.1093/hmg/ddr557

MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic... Read More about A meckelin-filamin a interaction mediates ciliogenesis.

High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance (2012)
Journal Article
Szymanska, K., Wheway, G., Natarajan, S., Higgins, J., Adams, M., Tomlinson, D. C., & Johnson, C. A. (2012). High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance. Cilia, 1(S1), P49. https://doi.org/10.1186/2046-2530-1-S1-P49

Cilia are small, hair-like structures occurring on the apical surface of most of vertebrate cells. Defects in cilia cause a range of developmental phenotypes grouped into conditions called ciliopathies. Our aim is to dissect the structure and functio... Read More about High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance.

MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways (2012)
Journal Article
Wheway, G., Abdelhamed, Z., Natarajan, S., & Johnson, C. A. (2012). MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways. Cilia, 1(S1), P108. https://doi.org/10.1186/2046-2530-1-S1-P108

MKS1, a ciliary protein containing a B9 domain of unknown function, plays an important role in ciliogenesis. Mutation of the MKS1 gene causes the neonatal lethal multi-organ developmental condition Meckel-Gruber syndrome, characterized by severe cili... Read More about MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways.