Skip to main content

Research Repository

Advanced Search

All Outputs (89)

Investigating the role of BCATc in autophagy and its implications in Alzheimer's disease (2024)
Thesis
Edward, R. Investigating the role of BCATc in autophagy and its implications in Alzheimer's disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10732083

Background: Autophagy, crucial in maintaining cellular health, is often dysregulated in neurodegenerative conditions such as Alzheimer’s disease (AD). Recent data shows that the cytosolic branched chain aminotransferase (BCATc) protein plays a pivota... Read More about Investigating the role of BCATc in autophagy and its implications in Alzheimer's disease.

Minimising infection risk of implantable titanium (2023)
Thesis
Britton, S. Minimising infection risk of implantable titanium. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10791885

The use of antibacterial coatings on bone biomaterial has attracted interest from various fields such as orthopaedics, dentistry and veterinary medicine. However, the process of attaching suitable compounds to biomaterial surfaces in a stable manner... Read More about Minimising infection risk of implantable titanium.

Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders (2023)
Thesis
Saidykhan, J. Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10774108

Haemostatic disorders cause excessive bleeding and clotting and result in high morbidity and mortality worldwide, but especially in low-income areas which often lack suitable facilities and expertise for affordable diagnosis and treatment. Simple and... Read More about Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders.

Computer simulations of peptide nucleic acid under external force (2023)
Thesis
Goodman, J. Computer simulations of peptide nucleic acid under external force. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10829665

The research question, “Can molecular dynamics be used to assess and screen the single-molecular binding properties of a candidate bioadhesive?" is answered in this thesis using molecular dynamics simulations. A ‘nearest-neighbour’ model was produced... Read More about Computer simulations of peptide nucleic acid under external force.

Exploring the interaction between online practices and offline domestic food practices in family homes: Implications for food waste reduction campaigns (2023)
Thesis
Ridgway, A. Exploring the interaction between online practices and offline domestic food practices in family homes: Implications for food waste reduction campaigns. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10307861

Food waste is a significant problem in the food system, contributing to the environmental impact of food production and distribution as well as food inequality. In the UK and other high-income countries, a high proportion of the food waste in the foo... Read More about Exploring the interaction between online practices and offline domestic food practices in family homes: Implications for food waste reduction campaigns.

Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses (2023)
Thesis
Visser, H. Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10014381

Confronted with DNA damage, cells can undergo cell cycle arrest and DNA repair, or cell death. However, communal DNA damage response (DDR) proteins involved in each of these cell fates, has confounded attempts to unravel the molecular nuances that dr... Read More about Profiling the DNA damage response dynamics at sub-lethal and lethal temozolomide doses.

The development of environmental DNA (eDNA) techniques for the detection and monitoring of the critically endangered European eel, Anguilla anguilla (2023)
Thesis
Weldon, L. The development of environmental DNA (eDNA) techniques for the detection and monitoring of the critically endangered European eel, Anguilla anguilla. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/9259727

The European eel Anguilla anguilla, is currently classified as critically endangered (IUCN Red List). In the UK the eel population is estimated at less than 5% of numbers observed in the 1980s and this trend is reflected throughout its European fresh... Read More about The development of environmental DNA (eDNA) techniques for the detection and monitoring of the critically endangered European eel, Anguilla anguilla.

Towards a rapid diagnostic method to identify bacteria associated with AOD (2022)
Thesis
Bueno Gonzalez, V. Towards a rapid diagnostic method to identify bacteria associated with AOD. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7717906

British oaks, Quercus robur and Q. petraea are threatened by Acute Oak Decline (AOD). Severe cases are lethal within five years. Symptoms include bleeding, longitudinal, necrotic cracks in the bark, from which a dark fluid emanates. AOD is caused by... Read More about Towards a rapid diagnostic method to identify bacteria associated with AOD.

Camera trapping and occupancy model as a tool for monitoring the carnivore’s guild in Wadi Wurayah Man and Biosphere Reserve (2022)
Thesis
Chreiki, M. Camera trapping and occupancy model as a tool for monitoring the carnivore’s guild in Wadi Wurayah Man and Biosphere Reserve. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/9002977

Understanding species habitat relationships and their relative importance to the carnivore guild is fundamental to determining optimal conservation strategies and guiding long-term management efforts in a man and biosphere reserve. In this study, I u... Read More about Camera trapping and occupancy model as a tool for monitoring the carnivore’s guild in Wadi Wurayah Man and Biosphere Reserve.

Developing new chemical-based sensors for the detection of volatile compounds (2022)
Thesis
Fois, M. Developing new chemical-based sensors for the detection of volatile compounds. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/8193761

This research project aims to enhance the performance of a series of chemical-based sensor devices. In particular, metal oxide gas sensors. These materials are well known and primarily employed in several applications, thanks to their characteristic... Read More about Developing new chemical-based sensors for the detection of volatile compounds.

Re-thinking transformative visitor experience in a science exhibition: Implications for science communication theory and practice (2022)
Thesis
Judge, D. Re-thinking transformative visitor experience in a science exhibition: Implications for science communication theory and practice. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7589437

Science communication addresses some of the contemporary world’s most challenging and intractable problems. Whether climate change or the recent coronavirus pandemic, science communication has an important role to play in these urgent issues. Concurr... Read More about Re-thinking transformative visitor experience in a science exhibition: Implications for science communication theory and practice.

Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells (2021)
Thesis
Robson, J. Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7434617

Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related death. The global burden of CRC is rising, particularly in younger populations. This increase has been attributed to lifestyle factor... Read More about Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells.

The experience of emotion in people with Fibromyalgia: A thematic analysis (2021)
Thesis
Jones, L. The experience of emotion in people with Fibromyalgia: A thematic analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7045706

Emotion is widely recognised as one of the central factors which influence the experience and management of pain (International Association for the Study of Pain, 2020). There is a substantial research base on how emotion may exacerbate or ameliorate... Read More about The experience of emotion in people with Fibromyalgia: A thematic analysis.

Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing (2021)
Thesis
Vernon, A. Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7043785

Genotoxicity testing is required for all new compounds utilising 2D assays, such as the in vitro micronucleus (MN) assay, before moving to in vivo assays such as the rodent bone marrow MN assay. Two-dimensional cell culture has traditionally been use... Read More about Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing.

Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface (2021)
Thesis
Almalki, S. Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6000940

Homing of haematopoietic stem cells (HSCs) to the bone marrow (BM) niches after transplantation (HSCT) is controlled by chemotactic signalling released from the BM microenvironment. This process is incompletely understood, but some factors are known,... Read More about Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface.

Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
Wodi, C. Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490771

This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1. SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms (2021)
Thesis
Henderson, J. The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6093082

Carbapenems are broad spectrum antibiotics often reserved for the critically ill. Their increased and, often, inappropriate use, has led to the development of resistance, through acquisition of carbapenemase enzymes. There are five carbapenemases tha... Read More about The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms.

The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean (2020)
Thesis
Meek, S. The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6442771

Seagrass meadows are vital coastal habitats that support a wide array of species and provide numerous ecosystem services. The area of seagrass meadow has declined significantly, at a rate of about 5% per year, since 1980. Emerging techniques for seag... Read More about The use of emerging techniques to understand seagrass ecosystems: Case studies using Posidonia oceanica in the Eastern Aegean.

Vaccine movements on social media: A visual and network analysis (2020)
Thesis
Milani, E. Vaccine movements on social media: A visual and network analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/5936098

Vaccines are considered one of the most effective public health interventions, but they have been subject to opposition since they were first proposed. Anti-vaccine activists disseminate and sensationalise objections to vaccinations through various c... Read More about Vaccine movements on social media: A visual and network analysis.