All Outputs (3)

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease (2020)
Journal Article
Harris, M., El Hindy, M., Usmari-Moraes, M., Hudd, F., Shafei, M., Dong, M., …Conway, M. E. (in press). BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease. Free Radical Biology and Medicine, https://doi.org/10.1016/j.freeradbiomed.2020.01.019

Leucine, nutrient signal and substrate for the branched chain aminotransferase (BCAT) activates the mechanistic target of rapamycin (mTORC1) and regulates autophagic flux, mechanisms implicated in the pathogenesis of neurodegenerative conditions such... Read More about BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease.

Immunotherapeutic and pharmacological approaches for the treatment of Alzheimer’s disease (2018)
Journal Article
Usmari Moraes, M., Gaudet, T., Hull, J., & Conway, M. E. (2018). Immunotherapeutic and pharmacological approaches for the treatment of Alzheimer’s disease. Bioscience Horizons, 11, 1-7

The development of efficacious treatments targeting Alzheimer’s disease (AD) aetiology has been proved an extensive, time consuming task. Currently prescribed therapies, primarily acetylcholinesterase inhibitors such as donepezil and the NMDAreceptor... Read More about Immunotherapeutic and pharmacological approaches for the treatment of Alzheimer’s disease.

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2017)
Journal Article
Hull, J., Usmari Moraes, M., Brookes, E., Love, S., & Conway, M. E. (2018). Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism. Neurochemistry International, 112, 49-58. https://doi.org/10.1016/j.neuint.2017.10.014

© 2017 Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, the... Read More about Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.