All Outputs (36)

Compositional shifts within the denture-associated bacteriome in pneumonia - an analytical cross-sectional study (2023)
Journal Article
Twigg, J. A., Smith, A., Haury, C., Wilson, M. J., Lees, J., Waters, M., & Williams, D. W. (2023). Compositional shifts within the denture-associated bacteriome in pneumonia - an analytical cross-sectional study. Journal of Medical Microbiology, 72(6), https://doi.org/10.1099/jmm.0.001702

Introduction. Bacterial pneumonia is a common cause of morbidity and mortality in elderly individuals. While the incidence of edentulism is falling, approximately 19 % of the UK population wear a full or partial removable denture. Despite advances in... Read More about Compositional shifts within the denture-associated bacteriome in pneumonia - an analytical cross-sectional study.

Comparative analysis of vaginal microbiota sampling using menstrual cups and high vaginal swabs in pregnant women living with HIV-1 infection (2023)
Journal Article
Short, C. S., Quinlan, R., Lee, Y. S., Preda, V. G., Smith, A., Marchesi, J. R., …Taylor, G. P. (2023). Comparative analysis of vaginal microbiota sampling using menstrual cups and high vaginal swabs in pregnant women living with HIV-1 infection. Frontiers in Cellular and Infection Microbiology, 13, https://doi.org/10.3389/fcimb.2023.1190160

Background: Menstrual cups (MCs) are increasingly used to collect cervicovaginal secretions to characterise vaginal mucosal immunology, in conjunction with high vaginal swabs (HVS) for metataxonomics, particularly in HIV transmission studies. We hypo... Read More about Comparative analysis of vaginal microbiota sampling using menstrual cups and high vaginal swabs in pregnant women living with HIV-1 infection.

Identifying volatile and non‐volatile organic compounds to discriminate cultivar, growth location, and stage of ripening in olive fruits and oils (2022)
Journal Article
Greco, M., Spadafora, N., Shine, M., Smith, A., Muto, A., Muzzalupo, I., …Bitonti, M. B. (2022). Identifying volatile and non‐volatile organic compounds to discriminate cultivar, growth location, and stage of ripening in olive fruits and oils. Journal of the Science of Food and Agriculture, 102(11), 4500-4513. https://doi.org/10.1002/jsfa.11805

BACKGROUND: There is increasing consumer demand for olive oil to be traceable. However, genotype, environmental factors, and stage of maturity, all affect the flavor and composition of both the olives and olive oil. Few studies have included all thre... Read More about Identifying volatile and non‐volatile organic compounds to discriminate cultivar, growth location, and stage of ripening in olive fruits and oils.

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation (2021)
Journal Article
Grewal, K., Lee, Y. S., Smith, A., Brosens, J. J., Bourne, T., Al-Memar, M., …Bennett, P. R. (2021). Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation. BMC Medicine, 20(1), Article 38. https://doi.org/10.1186/s12916-021-02227-7

Background: Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial composition and the local immu... Read More about Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation.

Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration (2021)
Journal Article
Short, C. S., Quinlan, R. A., Wang, X., Preda, V. G., Smith, A., Marchesi, J. R., …Taylor, G. P. (2021). Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration. Frontiers in Cellular and Infection Microbiology, 11, Article 750103. https://doi.org/10.3389/fcimb.2021.750103

Background: Pregnant women living with HIV infection (PWLWH) have elevated rates of preterm birth (PTB) in which HIV and cART are implicated. PWLWH also have a high prevalence of adverse vaginal microbiota, which associate with genital tract inflamma... Read More about Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration.

The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia (2021)
Journal Article
Mitra, A., MacIntyre, D. A., Paraskevaidi, M., Moscicki, A. B., Mahajan, V., Smith, A., …Kyrgiou, M. (2021). The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia. Genome Medicine, 13(1), Article 176. https://doi.org/10.1186/s13073-021-00977-w

Background: Vaginal microbiota (VMB) composition is altered in women with cervical intra-epithelial neoplasia (CIN) compared to healthy controls and is associated with disease progression. However, the impact of CIN excision on the VMB and innate imm... Read More about The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia.

Telomere length in cystic fibrosis patients – Are patients with CF ageing too quickly? (2021)
Journal Article
Ashworth, I., Norris, K., Thia, L., Dodge, J. A., Grimstead, J. W., Jones, R. E., …Duckers, J. (2021). Telomere length in cystic fibrosis patients – Are patients with CF ageing too quickly?. International Journal of Aging Research, 4, Article 90. https://doi.org/10.28933/ijoar-2021-06-2005

Life expectancy for patients living with Cystic Fibrosis (CF) is increasing year on year and there is growing interest in the ageing process in CF. Telomeres are repetitive sequences of DNA that cap the ends of eukaryotic chromosomes and shorten with... Read More about Telomere length in cystic fibrosis patients – Are patients with CF ageing too quickly?.

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth (2021)
Journal Article
Pruski, P., Correia, G. D., Lewis, H. V., Capuccini, K., Inglese, P., Chan, D., …MacIntyre, D. A. (2021). Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth. Nature Communications, 12(1), Article 5967. https://doi.org/10.1038/s41467-021-26215-w

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)... Read More about Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth.

O-129 Lactobacillus deplete vaginal microbial composition is associated with chromosomally normal miscarriage and local inflammation (2021)
Journal Article
Grewal, K., Lee, Y., Smith, A., Brosens, J., Al-Memar, M., Bourne, T., …Bennett, P. (2021). O-129 Lactobacillus deplete vaginal microbial composition is associated with chromosomally normal miscarriage and local inflammation. Human Reproduction, 36(Supplement_1), https://doi.org/10.1093/humrep/deab126.054

Study question To investigate the vaginal microbial composition and the local immune response in chromosomally normal and abnormal miscarriages and compare this to uncomplicated pregnancies delivering at term. Summary answer We show that euploid... Read More about O-129 Lactobacillus deplete vaginal microbial composition is associated with chromosomally normal miscarriage and local inflammation.

The association between obesity and weight loss after bariatric surgery on the vaginal microbiota (2021)
Journal Article
Raglan, O., MacIntyre, D. A., Mitra, A., Lee, Y. S., Smith, A., Assi, N., …Kyrgiou, M. (2021). The association between obesity and weight loss after bariatric surgery on the vaginal microbiota. Microbiome, 9(1), Article 124. https://doi.org/10.1186/s40168-021-01011-2

Background: Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammat... Read More about The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.

Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases (2021)
Journal Article
Smith, A. (2021). Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases. Folia Microbiologica, 66(3), 399-410. https://doi.org/10.1007/s12223-020-00846-w

Globally, it is estimated that there are 2 billion cases of diarrhoeal disease each year, with 525,000 children under the age of 5years, dying from diarrhoea. This also affects 1 in 5 people in the UK each year. Rapid diagnosis, appropriate treatment... Read More about Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases.

Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis (2020)
Journal Article
Winearls, S., Swingwood, E. L., Hardaker, C. L., Smith, A. M., Easton, F. M., Millington, K. J., …Curtis, K. J. (2020). Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis. BMJ Open Respiratory Research, 7(1), e000711. https://doi.org/10.1136/bmjresp-2020-000711

The global pandemic of COVID-19 has challenged the management of hypoxaemic respiratory failure and strained intensive care unit resources. While prone positioning (PP) is an established therapy in mechanically ventilated patients with acute respirat... Read More about Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis.

The effect of residual food stain on Candida albicans colonisation of denture acrylics (2020)
Journal Article
Smith, A., Williams, D., Bradshaw, D., Milward, P., Al Kutubi, S., & Rowe, W. (2020). The effect of residual food stain on Candida albicans colonisation of denture acrylics. Dental Oral Biology and Craniofacial Research, 3(2), https://doi.org/10.31487/j.DOBCR.2020.02.06

Published: NA Keywords: Candida albicans dentures food stains denture-induced stomatitis A B S T R A C T Objectives: In the UK, 19% of adults wear dentures. Failure to keep a denture clean can lead to staining from foods, along with subsequent coloni... Read More about The effect of residual food stain on Candida albicans colonisation of denture acrylics.

The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions (2020)
Journal Article
Mitra, A., MacIntyre, D. A., Ntritsos, G., Smith, A., Tsilidis, K. K., Marchesi, J. R., …Kyrgiou, M. (2020). The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications, 11, Article 1999. https://doi.org/10.1038/s41467-020-15856-y

Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequ... Read More about The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions.

The association between vaginal bacterial composition and miscarriage: a nested case-control study (2019)
Journal Article
Al-memar, M., Bobdiwala, S., Fourie, H., Mannino, R., Lee, Y., Smith, A., …MacIntyre, D. (2020). The association between vaginal bacterial composition and miscarriage: a nested case-control study. BJOG: An International Journal of Obstetrics and Gynaecology, 127(2), 264-274. https://doi.org/10.1111/1471-0528.15972

© 2019 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists Objective: To characterise vaginal bacterial composition in early pre... Read More about The association between vaginal bacterial composition and miscarriage: a nested case-control study.

Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis (2019)
Journal Article
Morse, D. J., Smith, A., Wilson, M. J., Marsh, L., White, L., Posso, R., …Williams, D. W. (2019). Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports, 9(1), Article 10228. https://doi.org/10.1038/s41598-019-46494-0

Denture-associated stomatitis (DS) affects over two-thirds of denture-wearers. DS presents as erythema of the palatal mucosa in areas where denture-surface associated polymicrobial biofilms containing the fungus Candida albicans exist. The contributi... Read More about Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis.

Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development (2019)
Journal Article
Trefan, L., Akbari, A., Paranjothy, S., Farewell, D. M., Gartner, A., Fone, D., …Moore, S. (2019). Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development. International Journal of Population Data Science, 4(1), https://doi.org/10.23889/ijpds.v4i1.581

Introduction: Excessive alcohol consumption has adverse effects on health and there is a recognised need for the longitudinal analysis of population data to improve our understanding of the patterns of alcohol use, harms to consumers and those in the... Read More about Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development.

Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis (2019)
Journal Article
Ovadia, C., Perdones‐Montero, A., Spagou, K., Smith, A., Sarafian, M. H., Gomez‐Romero, M., …Williamson, C. (2019). Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology, 70(1), 276-293. https://doi.org/10.1002/hep.30661

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metab... Read More about Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.

Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage (2019)
Journal Article
Brown, R. G., Chan, D., Terzidou, V., Lee, Y. S., Smith, A., Marchesi, J. R., …Bennett, P. R. (2019). Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage. BJOG: An International Journal of Obstetrics and Gynaecology, 126(7), 916-925. https://doi.org/10.1111/1471-0528.15600

Objective: To investigate the relation between vaginal microbiota composition and outcome of rescue cervical cerclage. Design: Prospective observational study. Setting: Queen Charlotte's and Chelsea Hospital, London. Population: Twenty singleton preg... Read More about Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage.

Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes (2018)
Journal Article
Lee, Y. S., Brown, R. G., Al-Memar, M., Marchesi, J. R., Smith, A., Chan, D., …MacIntyre, D. A. (2019). Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Translational Research, The Journal of Laboratory and Clinical Medicine, 207, 30-43. https://doi.org/10.1016/j.trsl.2018.12.005

© 2019 The Authors Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversit... Read More about Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes.