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All Outputs (126)

Alternatives to the face-to-face consultation in general practice: Focused ethnographic case study (2018)
Journal Article
Atherton, H., Brant, H., Ziebland, S., Bikker, A., Campbell, J., Gibson, A., …Salisbury, C. (2018). Alternatives to the face-to-face consultation in general practice: Focused ethnographic case study. British Journal of General Practice, 68(669), e293-e300. https://doi.org/10.3399/bjgp18X694853

© British Journal of General Practice. Background NHS policy encourages general practices to introduce alternatives to the face-to-face consultation, such as telephone, email, e-consultation systems, or internet video. Most have been slow to adopt th... Read More about Alternatives to the face-to-face consultation in general practice: Focused ethnographic case study.

Long-term annual and monthly changes in mysids and caridean decapods in a macrotidal estuarine environment in relation to climate change and pollution (2018)
Journal Article
Plenty, S. J., Tweedley, J. R., Bird, D. J., Newton, L. C., Warwick, R. M., Henderson, P. A., …Potter, I. C. (2018). Long-term annual and monthly changes in mysids and caridean decapods in a macrotidal estuarine environment in relation to climate change and pollution. Journal of Sea Research, 137, 35-46. https://doi.org/10.1016/j.seares.2018.03.007

© 2018 Elsevier B.V. A 26-year time series of monthly samples from the water intake of a power station has been used to analyse the trends exhibited by number of species, total abundance, and composition of the mysids and caridean decapods in the inn... Read More about Long-term annual and monthly changes in mysids and caridean decapods in a macrotidal estuarine environment in relation to climate change and pollution.

Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., & Killard, A. (2018). Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity. Sensors and Actuators B: Chemical, 266, 472-476. https://doi.org/10.1016/j.snb.2018.03.145

© 2018 Elsevier B.V. It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, th... Read More about Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity.

Measuring the effectiveness of catch-up MMR delivered by school nurses compared to signposting to general practice on improving MMR coverage: A retrospective cohort study (2018)
Presentation / Conference
Altinoluk-Davis, F., Gray, S., Bray, I., & Powell, J. (2018, March). Measuring the effectiveness of catch-up MMR delivered by school nurses compared to signposting to general practice on improving MMR coverage: A retrospective cohort study. Presented at South West Public Health Scientific Conference 2018, Bristol, England

Aim: This study aims to determine the extent to which increased coverage of at least one dose and two doses of MMR differs between areas in which school nurses deliver catch-up MMR doses to adolescents in school settings, compared to signposting to g... Read More about Measuring the effectiveness of catch-up MMR delivered by school nurses compared to signposting to general practice on improving MMR coverage: A retrospective cohort study.

Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets (2018)
Journal Article
Porazinski, S., & Ladomery, M. (2018). Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets. Genes, 9(3), 161. https://doi.org/10.3390/genes9030161

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement o... Read More about Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets.

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma (2018)
Journal Article
Szemes, M., Greenhough, A., Melegh, Z. B., Malik, S., Yuksel, A., Catchpoole, D., …Malik, K. (2018). Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma. Neoplasia, 20(4), 335-350. https://doi.org/10.1016/j.neo.2018.01.009

© 2018 Neuroblastoma is one of the commonest and deadliest solid tumours of childhood, and is thought to result from disrupted differentiation of the developing sympathoadrenergic lineage of the neural crest. Neuroblastoma exhibits intra- and intertu... Read More about Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.

The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients (2018)
Journal Article
Peyravian, N., Larki, P., Gharib, E., Nazemalhosseini-Mojarad, E., Anaraki, F., Young, C., …Zali, M. (2018). The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients. Biomedicines, 6(1), 27. https://doi.org/10.3390/biomedicines6010027

A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes-information which is also important in assessing any possibilities of lymph node resection so as to i... Read More about The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients.

A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology (2018)
Journal Article
Evans, C., Hvoslefeide, M., Thomas, R. S., Kidd, E., & Good, M. (2018). A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology. Neurobiology of Learning and Memory, 149, 46-57. https://doi.org/10.1016/j.nlm.2018.02.004

© 2018 Elsevier Inc. Three experiments examined the ability of mice to forage efficiently for liquid rewards in pots located in an open field arena. Search behaviour was unconstrained other than by the walls of the arena. All mice acquired the task w... Read More about A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology.

GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients (2018)
Journal Article
Hadizadeh, M., Mohaddes Ardebili, S., Salehi, M., Young, C., Mokarian, F., McClellan, J., …Bonab, M. A. (2018). GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients. Biomedicines, 6(1), 23. https://doi.org/10.3390/biomedicines6010023

Lymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function, which leads to obstruction of the lymphatic system. Secondary lymphedema is a progressive and incurable condition, most often manife... Read More about GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients.

A Systematic Review of the Effectiveness of Acceptance and Commitment Therapy (ACT) for Body Image Dissatisfaction and Weight Self-Stigma in Adults (2018)
Journal Article
Griffiths, C., Williamson, H., Zucchelli, F., Paraskeva, N., & Moss, T. (2018). A Systematic Review of the Effectiveness of Acceptance and Commitment Therapy (ACT) for Body Image Dissatisfaction and Weight Self-Stigma in Adults. Journal of Contemporary Psychotherapy, 48(4), 189-204. https://doi.org/10.1007/s10879-018-9384-0

© 2018, The Author(s). Body image dissatisfaction (BID) and weight self-stigma are prevalent and associated with physical and psychological ill-health. Acceptance and Commitment Therapy (ACT) is increasingly employed for both, yet little is known abo... Read More about A Systematic Review of the Effectiveness of Acceptance and Commitment Therapy (ACT) for Body Image Dissatisfaction and Weight Self-Stigma in Adults.

Fungal wars: The underlying molecular repertoires of combating mycelia (2018)
Journal Article
Ujor, V. C., Adukwu, E. C., & Okonkwo, C. C. (2018). Fungal wars: The underlying molecular repertoires of combating mycelia. Fungal Biology, 122(4), 191-202. https://doi.org/10.1016/j.funbio.2018.01.001

© 2018 British Mycological Society Non-self contact between fungi elicits strong morphological and biochemical reactions in the mycelia of interacting species. Although these reactions appear to be species- and interaction-specific, some responses su... Read More about Fungal wars: The underlying molecular repertoires of combating mycelia.

Signaling through the primary cilium (2018)
Journal Article
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018). Signaling through the primary cilium. Frontiers in Cell and Developmental Biology, 6(FEB), https://doi.org/10.3389/fcell.2018.00008

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remainin... Read More about Signaling through the primary cilium.

Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee (2018)
Journal Article
Adriaenssens, E. M., Wittmann, J., Kuhn, J. H., Turner, D., Sullivan, M. B., Dutilh, B. E., …Rodney Brister, J. (2018). Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee. Archives of Virology, 163(4), 1125-1129. https://doi.org/10.1007/s00705-018-3723-z

The prokaryotic virus community is represented at the International Committee on Taxonomy of Viruses (ICTV) by the Bacterial and Archaeal Viruses Subcommittee. Since our last report, the committee composition has changed, and a large number of taxono... Read More about Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee.

7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes (2018)
Journal Article
Pilipenko, N., Rasmussen, M. K., Doran, O., & Zamaratskaia, G. (2018). 7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes. Food and Chemical Toxicology, 113, 14-18. https://doi.org/10.1016/j.fct.2018.01.020

© 2018 Elsevier Ltd Warfarin is a commonly used anticoagulant drug and is a derivate of coumarin. Cytochrome P450 2C9 (CYP2C9) plays the key role in transformation of coumarin and thus, influences determination of warfarin dosage. A number of factors... Read More about 7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes.

Alter egos: An exploration of the perspectives and identities of science comic creators (2018)
Journal Article
Collver, J., & Weitkamp, E. (2018). Alter egos: An exploration of the perspectives and identities of science comic creators. JCOM: Journal of Science Communication, 17(1), 1-22. https://doi.org/10.22323/2.17010201

© 2018 The Author(s). While academic interest in science comics has been growing in recent years, the creators of these materials remain understudied. This research aimed to explore the experiences and views of science comic creators through the lens... Read More about Alter egos: An exploration of the perspectives and identities of science comic creators.

Direct thermal desorption gas chromatographic determination of toxicologically relevant concentrations of ethylene glycol in whole blood (2018)
Journal Article
Robson, J., Townsend, S., Bowdler, P., & Honeychurch, K. C. (2018). Direct thermal desorption gas chromatographic determination of toxicologically relevant concentrations of ethylene glycol in whole blood. Analyst, 143(4), 963-969. https://doi.org/10.1039/c7an02095c

© 2018 The Royal Society of Chemistry. A simple and rapid method involving thermal desorption gas chromatography (TD-GC) with flame ionisation detection has been successfully developed for the determination of ethylene glycol in whole blood. No sampl... Read More about Direct thermal desorption gas chromatographic determination of toxicologically relevant concentrations of ethylene glycol in whole blood.

Visualization of phage genomic data: Comparative genomics and publication-quality diagrams (2018)
Book Chapter
Reynolds, D. M., Turner, D., Sutton, J. M., Reynolds, D. M., Sim, E. M., & Petty, N. K. (2018). Visualization of phage genomic data: Comparative genomics and publication-quality diagrams. In R. Lavigne, A. M. Kropinski, & M. Clokie (Eds.), Bacteriophages. Methods in Molecular Biology (239-260). New York, NY: Springer. https://doi.org/10.1007/978-1-4939-7343-9_18

© 2018, Springer Science+Business Media LLC. The presentation of bacteriophage genomes as diagrams allows the location and organization of features to be communicated in a clear and effective manner. A wide range of software applications are availabl... Read More about Visualization of phage genomic data: Comparative genomics and publication-quality diagrams.

Monitoring the Sanje mangabey population in Tanzania while engaging the local community (2018)
Book Chapter
Fernandez, D., McCabe, G., & Ehardt, C. Monitoring the Sanje mangabey population in Tanzania while engaging the local community. In A. Behie, J. Teichroeb, & N. Malone (Eds.), Primate Research and Conservation in the Anthropocene. Cambridge University Press. Manuscript submitted for publication

In order to successfully create and implement conservation management plans for endangered primates it is essential to work within local communities. This has been our approach in the Udzungwa region of Tanzania, where the Sanje Mangabey Project has... Read More about Monitoring the Sanje mangabey population in Tanzania while engaging the local community.