All Outputs (4)

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis (2018)
Journal Article
Greenhough, A., Bagley, C., Heesom, K. J., Gurevich, D. B., Gay, D., Bond, M., …Williams, A. C. (2018). Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Molecular Medicine, 10(11), Article e8699. https://doi.org/10.15252/emmm.201708699

© 2018 The Authors. Published under the terms of the CC BY 4.0 license Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecu... Read More about Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression (2018)
Journal Article
Gurevich, D. B., Severn, C. E., Twomey, C., Greenhough, A., Cash, J., Toye, A. M., …Martin, P. (2018). Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. EMBO Journal, 37(13), Article e97786. https://doi.org/10.15252/embj.201797786

© 2018 The Authors. Published under the terms of the CC BY 4.0 license Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies of healing. Here, we investigate the cellular interactions between innate immune cells... Read More about Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

Optimized delivery of siRNA into 3D tumor spheroid cultures in situ (2018)
Journal Article
Morgan, R. G., Chambers, A. C., Legge, D. N., Coles, S. J., Greenhough, A., & Williams, A. C. (2018). Optimized delivery of siRNA into 3D tumor spheroid cultures in situ. Scientific Reports, 8, Article 7952. https://doi.org/10.1038/s41598-018-26253-3

© 2018 The Author(s). 3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal and malignant human tissues. Despite this, gene-silencing studies using siRNA has proved difficult. In this study, we hav... Read More about Optimized delivery of siRNA into 3D tumor spheroid cultures in situ.

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma (2018)
Journal Article
Szemes, M., Greenhough, A., Melegh, Z. B., Malik, S., Yuksel, A., Catchpoole, D., …Malik, K. (2018). Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma. Neoplasia, 20(4), 335-350. https://doi.org/10.1016/j.neo.2018.01.009

© 2018 Neuroblastoma is one of the commonest and deadliest solid tumours of childhood, and is thought to result from disrupted differentiation of the developing sympathoadrenergic lineage of the neural crest. Neuroblastoma exhibits intra- and intertu... Read More about Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.