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All Outputs (104)

Comparative analysis of 37 Acinetobacter bacteriophages (2017)
Journal Article
Reynolds, D. M., Kropinski, A. M., Turner, D., Ackermann, H. W., Kropinski, A., Lavigne, R., …Reynolds, D. M. (2018). Comparative analysis of 37 Acinetobacter bacteriophages. Viruses, 10(1), 5. https://doi.org/10.3390/v10010005

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Members of the genus Acinetobacter are ubiquitous in the environment and the multipledrug resistant species A. baumannii is of significant clinical concern. This clinical relevance is currentl... Read More about Comparative analysis of 37 Acinetobacter bacteriophages.

A study of the analysis of acidic solutes by hydrophilic interaction chromatography (2017)
Journal Article
McCalley, D. V. (2018). A study of the analysis of acidic solutes by hydrophilic interaction chromatography. Journal of Chromatography A, 1534, 64-74. https://doi.org/10.1016/j.chroma.2017.12.045

© 2017 Elsevier B.V. The analysis of acidic solutes was compared on a cross-linked bonded amino phase and a neutral hybrid inorganic-organic amide phase, previously shown to give reasonable retention of acidic solutes. The amino column gave strong se... Read More about A study of the analysis of acidic solutes by hydrophilic interaction chromatography.

Setting up a cohort study in speech and language therapy: Lessons from The UK Cleft Collective Speech and Language (CC-SL) Study (2017)
Journal Article
Wren, Y., Humphries, K., Stock, N. M., Rumsey, N., Lewis, S., Davies, A., …Sandy, J. (2018). Setting up a cohort study in speech and language therapy: Lessons from The UK Cleft Collective Speech and Language (CC-SL) Study. International Journal of Language and Communication Disorders, 53(3), 421-430. https://doi.org/10.1111/1460-6984.12364

Background: Efforts to increase the evidence base in speech and language therapy are often limited by methodological factors which have restricted the strength of the evidence to the lower levels on the evidence hierarchy. Where higher graded studies... Read More about Setting up a cohort study in speech and language therapy: Lessons from The UK Cleft Collective Speech and Language (CC-SL) Study.

Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data (2017)
Journal Article
Lintott, P., Davison, S., van Breda, J., Kubasiewicz, L., Dowse, D., Daisley, J., …Mathews, F. (2018). Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data. Ecology and Evolution, 8(2), 935-941. https://doi.org/10.1002/ece3.3692

© 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. Acoustic surveys of bats are one of the techniques most commonly used by ecological practitioners. The results are used in Ecological Impact Assessments to assess the lik... Read More about Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data.

Empirical approaches for investigating the origins of structure in speech (2017)
Journal Article
Little, H., Rasilo, H., Van Der Ham, S., & Eryılmaz, K. (2017). Empirical approaches for investigating the origins of structure in speech. Interaction Studies, 18(3), 330-351. https://doi.org/10.1075/is.18.3.03lit

© John Benjamins Publishing Company. In language evolution research, the use of computational and experimental methods to investigate the emergence of structure in language is exploding. In this review, we look exclusively at work exploring the emerg... Read More about Empirical approaches for investigating the origins of structure in speech.

Conventionalisation and discrimination as competing pressures on continuous speech-like signals (2017)
Journal Article
Little, H., Eryılmaz, K., & De Boer, B. (2017). Conventionalisation and discrimination as competing pressures on continuous speech-like signals. Interaction Studies, 18(3), 352-375. https://doi.org/10.1075/is.18.3.04lit

© John Benjamins Publishing Company. Arbitrary communication systems can emerge from iconic beginnings through processes of conventionalisation via interaction. Here, we explore whether this process of conventionalisation occurs with continuous, audi... Read More about Conventionalisation and discrimination as competing pressures on continuous speech-like signals.

Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds (2017)
Journal Article
Gould, O., Ratcliffe, N. M., De Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds. Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

© 2017 IOP Publishing Ltd. There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications... Read More about Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds.

The STARTEC decision support tool for better tradeoffs between food safety, quality, nutrition, and costs in production of advanced ready-to-eat foods (2017)
Journal Article
Skjerdal, T., Gefferth, A., Spajic, M., Estanga, E. G., de Cecare, A., Vitali, S., …Halbert, C. (2017). The STARTEC decision support tool for better tradeoffs between food safety, quality, nutrition, and costs in production of advanced ready-to-eat foods. BioMed Research International, 2017, https://doi.org/10.1155/2017/6353510

A prototype decision support IT-tool for the food industry was developed in the STARTEC project. Typical processes and decision steps were mapped using real life production scenarios of participating food companies manufacturing complex ready-to-eat... Read More about The STARTEC decision support tool for better tradeoffs between food safety, quality, nutrition, and costs in production of advanced ready-to-eat foods.

Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil (2017)
Journal Article
Donald, J., Bonnett, S., Cutler, M., Majalap, N., Maxfield, P., & Ellwood, M. D. F. (2017). Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil. Forests, 8(12), Article 474. https://doi.org/10.3390/f8120474

As a source of ‘suspended soils’, epiphytes contribute large amounts of organic matter to the canopy of tropical rain forests. Microbes associated with epiphytes are responsible for much of the nutrient cycling taking place in rain forest canopies. H... Read More about Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil.

A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection (2017)
Journal Article
O'Connell, R. J., Wang, Y., Whittall, T., Neil, S., Britton, G., Mistry, M., …Lehner, T. (2017). A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-01188-3

© 2017 The Author(s). HIV infection affects 37 million people and about 1.7 million are infected annually. Among the phase III clinical trials only the RV144 vaccine trial elicited significant protection against HIV-1 acquisition, but the efficacy an... Read More about A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection.

Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence (2017)
Journal Article
Bonnett, S., Maltby, E., & Freeman, C. (2017). Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-10430-x

© 2017 The Author(s). Peatland ecosystems contain one-third of the world's soil carbon store and many have been exposed to drought leading to a loss of carbon. Understanding biogeochemical mechanisms affecting decomposition in peatlands is essential... Read More about Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence.

Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line (2017)
Journal Article
Daly, C. S., Flemban, A., Shafei, M., Conway, M. E., Qualtrough, D., & Dean, S. J. (2018). Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line. Oncology Reports, 39(2), 483-490. https://doi.org/10.3892/or.2017.6125

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc... Read More about Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line.

Temporal effects of disturbance on community composition in simulated stage-structured plant communities (2017)
Journal Article
Wang, Y., Wen, S., Farnon Ellwood, M. D., Miller, A. D., & Chu, C. (2018). Temporal effects of disturbance on community composition in simulated stage-structured plant communities. Ecology and Evolution, 8(1), 120-127. https://doi.org/10.1002/ece3.3660

© 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. In an era of global environmental change, understanding how disturbance affects the dynamics of ecological communities is crucial. However, few studies have theoretically... Read More about Temporal effects of disturbance on community composition in simulated stage-structured plant communities.

Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species (2017)
Journal Article
Muller, E., Ravel, S., Agret, C., Abrokwah, F., Dzahini-Obiatey, H., Galyuon, I., …Wetten, A. (2018). Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species. Virus Research, 244, 235-251. https://doi.org/10.1016/j.virusres.2017.11.019

© 2017 Elsevier B.V. Cacao swollen shoot virus is a member of the family Caulimoviridae, genus Badnavirus and is naturally transmitted to Theobroma cacao (L.) by several mealybug species. CSSV populations in West African countries are highly variable... Read More about Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species.

Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances (2017)
Journal Article
Hartill, V., Szymanska, K., Sharif, S. M., Wheway, G., & Johnson, C. A. (2017). Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances. Frontiers in Pediatrics, 5(244), 1-9. https://doi.org/10.3389/fped.2017.00244

© 2017 Hartill, Szymanska, Sharif, Wheway and Johnson. Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary... Read More about Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity (2017)
Journal Article
Morgan, R. G., Mortensson, E., Legge, D. N., Gupta, B., Collard, T. J., Greenhough, A., & Williams, A. C. (2018). LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity. British Journal of Cancer, 118(4), 558-565. https://doi.org/10.1038/bjc.2017.412

© The Author(s) named above 2018. Background:LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5 + cells are known to exist outside... Read More about LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2017)
Journal Article
Hull, J., Usmari Moraes, M., Brookes, E., Love, S., & Conway, M. E. (2018). Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism. Neurochemistry International, 112, 49-58. https://doi.org/10.1016/j.neuint.2017.10.014

© 2017 Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, the... Read More about Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.

Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia (2017)
Journal Article
May, J., Steven, J., Taylor, A., Dean, S., & Anderson, E. (2017). Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia. Mutagenesis, 32(6), 627. https://doi.org/10.1093/mutage/gex033

Treatment success in leukaemia is impacted by patient resistance to chemotherapy including cytarabine (ara-C) and the anthracycline daunorubicin (DNR) requiring rapid pre-screening testing. DNR is converted to daunorubicinol (DNRol) by carbonyl reduc... Read More about Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Journal Article
May, J., Robinson, G., Thorn, R., & Reynolds, D. (2017). Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS). Mutagenesis, 32(6), 622-623. https://doi.org/10.1093/mutage/gex033

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).