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A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture (2023)
Journal Article
Chen, B., Kiely, J., Luxton, R., & Williams, I. (2023). A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture. Bioelectrochemistry, 153, Article 108456. https://doi.org/10.1016/j.bioelechem.2023.108456

Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of event... Read More about A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture.

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance (2019)
Journal Article
Sonawane, V. R., Mohd Usman, M. S., Gatchie, L., Williams, I. S., Bharate, S. B., Jayaprakash, V., …Chaudhuri, B. (2019). CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance. European Journal of Pharmaceutical Sciences, 131, 177-194. https://doi.org/10.1016/j.ejps.2019.02.016

Microsomal cytochrome P450 (CYP) enzymes, isolated from recombinant bacterial/insect/yeast cells, are extensively used for drug metabolism studies. However, they may not always portray how a developmental drug would behave in human cells with intact... Read More about CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.