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Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells (2014)
Journal Article
Tezera, L. B., Page, K., Rhakimova, A., Salisbury, V., & Davenport, V. (2014). Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells. Advances in Microbiology, 04(02), 81-93. https://doi.org/10.4236/aim.2014.42013

In this study, we investigate the potential for oral Lactobacilli (LB) to afford innate protection against nasopharyngeal coloniser Neisseria meningitidis serogroup B (NmB), which causes the bulk of UK meningococcal disease. Oral isolates of L. plant... Read More about Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells.

Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ (2011)
Journal Article
Davenport, V., Jackson, S. K., Tezera, L. B., Hampton, J., Jackson, S. K., & Davenport, V. (2011). Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ. Cellular Microbiology, 13(4), 554-568. https://doi.org/10.1111/j.1462-5822.2010.01554.x

The upper respiratory tract commensal Neisseria lactamica (Nlac) induces protective humoral immunity against pathogenic Nmen serogoup B (Nmen), but whether it also affords anti-inflammatory mucosal protection, as reported for several gut commensals,... Read More about Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ.

Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig (2010)
Journal Article
Massari, P., Vaughan, A. T., Brackenbury, L. S., Masari, P., Davenport, V., Gorringe, A., …Williams, N. A. (2010). Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig. Journal of Immunology, 185(6), 3652-3660. https://doi.org/10.4049/jimmunol.0902468

Neisseria lactamica is a commensal bacteria that colonizes the human upper respiratory tract mucosa during early childhood. In contrast to the closely related opportunistic pathogen Neisseria meningitidis, there is an absence of adaptive cell-mediate... Read More about Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig.

Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency (2009)
Journal Article
Garcez, T. P., Morales-Aza, B., Glennie, S. J., Garcez, T. P., Davenport, V., Johnston, S. L., …Heyderman, R. S. (2009). Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency. Blood, 113(18), 4206-4212. https://doi.org/10.1182/blood-2008-08-171587

The importance of T cells in the generation of antigen-specific B-cell immunity has been extensively described, but the role B cells play in shaping T-cell memory is uncertain. In healthy controls, exposure to Neisseria meningitidis in the upper resp... Read More about Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency.

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease (2009)
Journal Article
Heyderman, R. S., Adegbola, R. A., Williams, N. A., Mitchell, T. J., Ota, M. O., Mureithi, M. W., …Heyderman, R. (2009). T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. Journal of Infectious Diseases, 200(5), 783-793. https://doi.org/10.1086/605023

Background. Streptococcus pneumoniae is a leading cause of vaccine-preventable disease worldwide. Pneumococcal protein antigens are currently under study as components of potential vaccines that offer protection against multiple serotypes. We have th... Read More about T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease.

Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage (2009)
Journal Article
Heyderman, R. S., Vaughan, A. T., Vaughan, A. T., Gorringe, A., Davenport, V., Williams, N. A., & Heyderman, S. (2009). Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage. Journal of Immunology, 182(4), 2231-2240. https://doi.org/10.4049/jimmunol.0802531

The normal flora that colonizes the mucosal epithelia has evolved diverse strategies to evade, modulate, or suppress the immune system and avoid clearance. Neisseria lactamica and Neisseria meningitidis are closely related obligate inhabitants of the... Read More about Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage.

Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B (2008)
Journal Article
Williams, N. A., Heyderman, R. S., Næss, L. M., Hobbs, C. G., Horton, R. E., Davenport, V., …Williams, N. (2008). Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B. Journal of Infectious Diseases, 198(5), 731-740. https://doi.org/10.1086/590669

Background. Nasopharyngeal carriage of meningococcus or related species leads to protective immunity in adolescence or early adulthood. This natural immunity is associated with mucosal and systemic T cell memory. Whether parenteral Neisseria meningit... Read More about Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B.

Tonsil T cell immunity to human papillomavirus in the absence of detectable virus in healthy adults (2008)
Journal Article
Hobbs, C. G., Hobbs, C. G. L., Groves, E., Davenport, V., Bailey, M., Williams, N. A., …Heyderman, R. S. (2008). Tonsil T cell immunity to human papillomavirus in the absence of detectable virus in healthy adults. Laryngoscope, 118(3), 459-463. https://doi.org/10.1097/MLG.0b013e31815aedb3

BACKGROUND: Human papillomavirus (HPV) is known to infect the epithelium of the upper aerodigestive tract; however, major questions regarding prevalence and persistence of infection, and their relation to local immune response, remain unanswered. OBJ... Read More about Tonsil T cell immunity to human papillomavirus in the absence of detectable virus in healthy adults.