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Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency (2009)
Journal Article
Garcez, T. P., Morales-Aza, B., Glennie, S. J., Davenport, V., Johnston, S. L., Williams, N. A., & Heyderman, R. S. (2009). Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency. Blood, 113(18), 4206-4212. https://doi.org/10.1182/blood-2008-08-171587

The importance of T cells in the generation of antigen-specific B-cell immunity has been extensively described, but the role B cells play in shaping T-cell memory is uncertain. In healthy controls, exposure to Neisseria meningitidis in the upper resp... Read More about Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency.

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease (2009)
Journal Article
Heyderman, R. S., Adegbola, R. A., Williams, N. A., Mitchell, T. J., Ota, M. O., Mureithi, M. W., …Davenport, V. (2009). T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. Journal of Infectious Diseases, 200(5), 783-793. https://doi.org/10.1086/605023

Background. Streptococcus pneumoniae is a leading cause of vaccine-preventable disease worldwide. Pneumococcal protein antigens are currently under study as components of potential vaccines that offer protection against multiple serotypes. We have th... Read More about T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease.

Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage (2009)
Journal Article
Heyderman, R. S., Vaughan, A. T., Gorringe, A., Davenport, V., & Williams, N. A. (2009). Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage. Journal of Immunology, 182(4), 2231-2240. https://doi.org/10.4049/jimmunol.0802531

The normal flora that colonizes the mucosal epithelia has evolved diverse strategies to evade, modulate, or suppress the immune system and avoid clearance. Neisseria lactamica and Neisseria meningitidis are closely related obligate inhabitants of the... Read More about Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage.