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Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., & Killard, A. (2018). Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity. Sensors and Actuators B: Chemical, 266, 472-476. https://doi.org/10.1016/j.snb.2018.03.145

© 2018 Elsevier B.V. It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, th... Read More about Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity.

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices (2017)
Journal Article
Killard, A. J., Donaghy, D., Gonzalez-Macia, L., Killard, A., & Raja, M. (2017). Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices. IET Circuits, Devices and Systems, 11(5), 504-511. https://doi.org/10.1049/iet-cds.2016.0500

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the desig... Read More about Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices.

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics (2017)
Journal Article
Killard, A. J., Baumann, R. R., Ahmadraji, T., Gonzalez-Macia, L., Ritvonen, T., Willert, A., …Killard, A. (2017). Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics. Analytical Chemistry, 89(14), 7447-7454. https://doi.org/10.1021/acs.analchem.7b01012

© 2017 American Chemical Society. Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic fu... Read More about Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics.

An electrochemical sensor device for measuring blood ammonia at the point of care (2017)
Journal Article
Killard, A. J., Brannelly, N. T., Brannelly, N., & Killard, A. (2017). An electrochemical sensor device for measuring blood ammonia at the point of care. Talanta, 167, 296-301. https://doi.org/10.1016/j.talanta.2017.02.025

© 2017 The level of ammonia in blood is relevant in a number of medical conditions. While ammonia is a marker of dysfunction, elevated ammonia is itself a serious medical emergency and can lead to significant and permanent neurological impairment if... Read More about An electrochemical sensor device for measuring blood ammonia at the point of care.

A printed and microfabricated sensor device for the sensitive low volume measurement of aqueous ammonia (2016)
Journal Article
Brannelly, N., & Killard, A. (2017). A printed and microfabricated sensor device for the sensitive low volume measurement of aqueous ammonia. Electroanalysis, 29(1), 162-171. https://doi.org/10.1002/elan.201600556

The measurement of low concentrations of ammonia in small sample volumes is required in biological, biomedical and environmental measurement applications. However, achieving this without instrumentation remains challenging. Here, sensor devices for t... Read More about A printed and microfabricated sensor device for the sensitive low volume measurement of aqueous ammonia.

Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation (2016)
Journal Article
Killard, A. J., Lakshmanan, R. S., Efremov, V., O’Donnell, J. S., & Killard, A. (2016). Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation. Analytical and Bioanalytical Chemistry, 408(24), 6581-6588. https://doi.org/10.1007/s00216-016-9689-3

© 2016, The Author(s). The coagulation of blood plasma in response to activation with a range of tissue factor (TF) concentrations was studied with a quartz crystal microbalance (QCM), where frequency and half width at half maximum (bandwidth) values... Read More about Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation.

A fully integrated microfluidic device for point of care monitoring of antithrombotics (2016)
Journal Article
Killard, A. J., Harris, L. F., Rainey, P., Lindahl, T. L., & Killard, A. (2016). A fully integrated microfluidic device for point of care monitoring of antithrombotics. Analytical Methods, 8(35), 6500-6505. https://doi.org/10.1039/c6ay01566b

© 2016 The Royal Society of Chemistry. The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current methods for measuring hypercoagulability often require trained technicians, large blood volumes, and result in... Read More about A fully integrated microfluidic device for point of care monitoring of antithrombotics.

Measurement of total cholesterol using an enzyme sensor based on a printed hydrogen peroxide electrocatalyst (2016)
Journal Article
Killard, A. J., Ahmadraji, T., Ahmadraji, T., & Killard, A. (2016). Measurement of total cholesterol using an enzyme sensor based on a printed hydrogen peroxide electrocatalyst. Analytical Methods, 8(13), 2743-2749. https://doi.org/10.1039/c6ay00468g

© 2016 The Royal Society of Chemistry. Cholesterol is a major modifiable risk factor in cardiovascular disease and can be effectively managed by a combination of medication and monitoring. There continues to be a need for new point-of-care diagnostic... Read More about Measurement of total cholesterol using an enzyme sensor based on a printed hydrogen peroxide electrocatalyst.

Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes (2015)
Journal Article
Killard, A. J., Cinti, S., Arduini, F., Moscone, D., Palleschi, G., Gonzalez-Macia, L., & Killard, A. (2015). Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes. Sensors and Actuators B: Chemical, 221, 187-190. https://doi.org/10.1016/j.snb.2015.06.054

© 2015 Elsevier B.V. Abstract Here we describe the construction and optimization of a cholesterol biosensor based on screen-printed electrodes (SPEs) modified with inkjet-printed Prussian blue nanoparticles (PBNPs). The deposition of PBNPs using inkj... Read More about Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes.

Development of a hydrogen peroxide sensor based on screen-printed electrodes modified with inkjet-printed prussian blue nanoparticles (2014)
Journal Article
Killard, A. J., Cinti, S., Arduini, F., Moscone, D., Palleschi, G., & Killard, A. (2014). Development of a hydrogen peroxide sensor based on screen-printed electrodes modified with inkjet-printed prussian blue nanoparticles. Sensors, 14(8), 14222-14234. https://doi.org/10.3390/s140814222

A sensor for the simple and sensitive measurement of hydrogen peroxide has been developed which is based on screen printed electrodes (SPEs) modified with Prussian blue nanoparticles (PBNPs) deposited using piezoelectric inkjet printing. PBNP-modifie... Read More about Development of a hydrogen peroxide sensor based on screen-printed electrodes modified with inkjet-printed prussian blue nanoparticles.

Modelling of blood component flexibility using quartz crystal microbalance (2014)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., Cullen, S., & Killard, A. (2014). Modelling of blood component flexibility using quartz crystal microbalance. Journal of Biorheology, 28(1), 45-54

Quartz crystal microbalance (QCM) is a sensitive technique for real-time monitoring of cell adsorption, aggregation and cell-to-surface interaction processes. However, cell adhesion time courses are usually considered as merely qualitative, being pre... Read More about Modelling of blood component flexibility using quartz crystal microbalance.

Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing (2014)
Journal Article
Killard, A. J., Hicks, S. M., & Killard, A. (2014). Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing. Sensors and Actuators B: Chemical, 194, 283-289. https://doi.org/10.1016/j.snb.2013.12.047

Composites of WO3 nanoparticles and water-soluble polyaniline (PANI) particles doped with dodecyl benzenesulphonic acid at different mass ratios were deposited onto interdigitated electrodes and characterised using electrochemical impedance spectrosc... Read More about Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing.

Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate (2014)
Journal Article
Wallace, G. G., Killard, A. J., Innis, P. C., Weng, B., Morrin, A., Shepherd, R., …Wallace, G. (2014). Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate. Journal of Materials Chemistry B, 2(7), 793-799. https://doi.org/10.1039/c3tb21378a

Printing has been widely used in the sensor industry for its speed, low cost and production scalability. In this work we present a wholly-printed polypyrrole (PPy) based biosensor produced by inkjet printing bioinks composed of dispersions of PPy nan... Read More about Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate.

A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements (2014)
Journal Article
Ahmadraji, T., Gonzalez-Macia, L., & Killard, A. (2014). A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements. Analytical Methods, 6, 3975-3981. https://doi.org/10.1039/C3AY42262C

High density lipoprotein cholesterol (HDL-C) is a modifiable risk factor in cardiovascular disease and devices suitable for its determination at the point of care are critical to the future management of hypercholesterolaemia. An electrochemical bios... Read More about A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements.

Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance (2014)
Journal Article
Killard, A. J., Cullen, S. M., Lakshmanan, R. S., Efremov, V., Cullen, S., & Killard, A. (2014). Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance. Sensors and Actuators B: Chemical, 192, 23-28. https://doi.org/10.1016/j.snb.2013.10.081

The coagulation of blood plasma and the effect of fibrinogen concentration were studied with a quartz crystal microbalance (QCM), where frequency and half-width at half-maximum (bandwidth) values measured from the conductance spectrum near resonant f... Read More about Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance.

Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors (2013)
Journal Article
Killard, A. J., Hibbard, T., Crowley, K., Kelly, F., Ward, F., Holian, J., …Killard, A. (2013). Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors. Analytical Chemistry, 85(24), 12158-12165. https://doi.org/10.1021/ac403472d

A device for measuring human breath ammonia was developed based on a single use, disposable, inkjet printed ammonia sensor fabricated using polyaniline nanoparticles. The device was optimized for sampling ammonia in human breath samples by addressing... Read More about Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors.


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