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Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes (2019)
Journal Article
Carmichael, R. E., Wilkinson, K. A., & Craig, T. J. (2019). Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes. Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-42574-3

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistan... Read More about Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes.

Protein SUMOylation regulates insulin secretion at multiple stages (2019)
Journal Article
Davey, J. S., Carmichael, R. E., & Craig, T. J. (2019). Protein SUMOylation regulates insulin secretion at multiple stages. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-39681-6

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the... Read More about Protein SUMOylation regulates insulin secretion at multiple stages.

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1 (2018)
Journal Article
Carmichael, R. E., Wilkinson, K. A., Craig, T. J., Ashby, M. C., & Henley, J. M. (2018). MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1. Scientific Reports, 8(1), 5263. https://doi.org/10.1038/s41598-018-23440-0

© 2018 The Author(s). Differential trafficking of AMPA receptors (AMPARs) to and from the postsynaptic membrane is a key determinant of the strength of excitatory neurotransmission, and is thought to underlie learning and memory. The transcription fa... Read More about MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Competition of reactive signals and thiol modifications of proteins (2017)
Journal Article
Hancock, J. T., Craig, T. J., & Whiteman, M. (2017). Competition of reactive signals and thiol modifications of proteins. https://doi.org/10.4172/2576-1471.1000170

It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the rea... Read More about Competition of reactive signals and thiol modifications of proteins.

SUMOylation of Syntaxin1A regulates presynaptic endocytosis (2015)
Journal Article
Henley, J. M., Craig, T. J., Anderson, D., Evans, A. J., Girach, F., & Henley, J. (2015). SUMOylation of Syntaxin1A regulates presynaptic endocytosis. Scientific Reports, 5, 17669. https://doi.org/10.1038/srep17669

Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis eve... Read More about SUMOylation of Syntaxin1A regulates presynaptic endocytosis.

SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation (2015)
Journal Article
Henley, J. M., Tang, L. T., Tang, L. T., Craig, T. J., & Henley, J. M. (2015). SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. Nature Communications, 6, 7728. https://doi.org/10.1038/ncomms8728

© 2015 Macmillan Publishers Limited. All rights reserved. Synapsins are key components of the presynaptic neurotransmitter release machinery. Their main role is to cluster synaptic vesicles (SVs) to each other and anchor them to the actin cytoskeleto... Read More about SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.


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