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A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust (2019)
Journal Article
Henderson, J., Ciesielczuk, H., Nelson, S., Wilks, M., & Cummins, M. (2020). A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust. Journal of Hospital Infection, 104(1), 12-19. https://doi.org/10.1016/j.jhin.2019.10.012

Summary Background There has been an increase in the number of carbapenemase-producing organisms documented across the UK over the past 10 years. From these, the ‘big five’ carbapenemases (KPC, OXA-48, IMP, VIM, and NDM) are the most common types r... Read More about A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust.

Prevalence of Carbapenemase Producing Organisms in East London, UK. (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., & Nelson, S. (2019, September). Prevalence of Carbapenemase Producing Organisms in East London, UK. Poster presented at IBMS Congress 2019, Birmingham

Carbapenemases are enzymes, produced by an array of common Gram-negative organisms, which hydrolyse the carbapenem antibiotics, conferring resistance [1]. The main protagonists are the “big five” carbapenemases, KPC, OXA-48, IMP, VIM and NDM, which h... Read More about Prevalence of Carbapenemase Producing Organisms in East London, UK..

Community prevalence of carbapenemase-producing organisms in East London (2019)
Journal Article
Henderson, J., Ciesielczuk, H., Nelson, S. M., & Wilks, M. (2019). Community prevalence of carbapenemase-producing organisms in East London. Journal of Hospital Infection, 103(2), 142-146. https://doi.org/10.1016/j.jhin.2019.04.014

Background: Over the last decade there has been a rapid, worldwide increase in carbapenem resistance, which is of growing concern. The main protagonists, the carbapenemases Klebsiella pneumoniae carbapenemase (KPC), oxacillinase β-lactamase 48 (OXA-4... Read More about Community prevalence of carbapenemase-producing organisms in East London.

Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., Nelson, S., & Wilks, M. (2019, April). Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK. Poster presented at 29th European Conference of Clinical Microbiology and Infectious Disease

A point prevalence study (PPS) to determine the carriage rate of carbapenemase producing organisms (CPOs) was performed across 4 sites at Barts Health NHS Trust (BHT), encompassing 2.5 million patients across three London boroughs: Tower Hamlets, New... Read More about Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK.

An in vitro biofilm model of Staphylococcus aureus infection of bone (2019)
Journal Article
Sweeney, E., Lovering, A., Bowker, K., MacGowan, A., & Nelson, S. (2019). An in vitro biofilm model of Staphylococcus aureus infection of bone. Letters in Applied Microbiology, 68(4), 294-302. https://doi.org/10.1111/lam.13131

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an invitro model of osteomyelitis. A bioluminescent st... Read More about An in vitro biofilm model of Staphylococcus aureus infection of bone.

Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells (2019)
Journal Article
Marques, C., & Nelson, S. (2019). Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells. Letters in Applied Microbiology, 68(4), 350-359. https://doi.org/10.1111/lam.13126

© 2019 The Society for Applied Microbiology The influence of growth phase and state on the survival and recovery of Pseudomonas aeruginosa exposed to ciprofloxacin was investigated using batch culture grown planktonic cells and disaggregated biofilm... Read More about Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells.

Community screening to determine the prevalence of carbapenemase producing organisms in East London, 2018 (2018)
Presentation / Conference
Henderson, J., Ciesielczuk, H., Nelson, S., & Wilks, M. (2018, November). Community screening to determine the prevalence of carbapenemase producing organisms in East London, 2018. Poster presented at Federation of Infection Sciences Conference 2018

Carbapenems are broad spectrum antibiotics reserved for patients who are extremely ill or suspected of having an infection caused by a multidrug resistant organism (Nordmann et al., 2011). Over the past ten years there has been a dramatic increase in... Read More about Community screening to determine the prevalence of carbapenemase producing organisms in East London, 2018.

Characterisation of a dual species perfusion biofilm model (2018)
Presentation / Conference
Steven, J., & Nelson, S. (2018, June). Characterisation of a dual species perfusion biofilm model. Poster presented at Microbiology Society Early Career Microbiologists’ Forum Summer Conference

An estimated 65–80% of human infections are biofilm-related. As the biofilm mode of growth significantly contributes to bacterial tolerance of antimicrobial treatment, this has important ramifications for patient morbidity and associated healthcare c... Read More about Characterisation of a dual species perfusion biofilm model.

Isolation and characterisation of bacteriophages for use against biofilms of Pseudomonas aeruginosa clinical isolates (2018)
Presentation / Conference
Box, J., Turner, D., & Nelson, S. (2018, June). Isolation and characterisation of bacteriophages for use against biofilms of Pseudomonas aeruginosa clinical isolates. Poster presented at Microbiology Society Early Career Microbiologists’ Forum Summer Conference

Pseudomonas aeruginosa is a World Health Organization priority 1, ESKAPE pathogen that is capable of causing a wide spectrum of nosocomial and community-acquired infections. It employs a wide range of antibiotic resistance mechanisms and is often dif... Read More about Isolation and characterisation of bacteriophages for use against biofilms of Pseudomonas aeruginosa clinical isolates.

Dual species biofilm culture of Staphylococcus aureus and a bioluminescent strain of Pseudomonas aeruginosa (2016)
Presentation / Conference
Steven, J., Robinson, G., & Nelson, S. (2016, October). Dual species biofilm culture of Staphylococcus aureus and a bioluminescent strain of Pseudomonas aeruginosa

Poster presentation. Introduction Pseudomonas aeruginosa and Staphylococcus aureus are significant pathogens of wounds and the cystic fibrosis lung. There are likely to be complex interactions between the two species, with biofilm co-culture aff... Read More about Dual species biofilm culture of Staphylococcus aureus and a bioluminescent strain of Pseudomonas aeruginosa.

Characterization of the Salmonella bacteriophage vB_SenS-Ent1 (2012)
Journal Article
Reynolds, D., Nelson, S., Turner, D., Hezwani, M., Nelson, S., Salisbury, V., & Reynolds, D. M. (2012). Characterization of the Salmonella bacteriophage vB_SenS-Ent1. Journal of General Virology, 93(PART 9), 2046-2056. https://doi.org/10.1099/vir.0.043331-0

The bacteriophage vB_SenS-Ent1 (Ent1) is a member of the family Siphoviridae of tailed bacteriophages and infects a broad range of serovars of the enteric pathogen Salmonella enterica. The virion particle is composed of an icosahedral head 64 nm in d... Read More about Characterization of the Salmonella bacteriophage vB_SenS-Ent1.

Characterization of the Salmonella bacteriophage vB_SenS-Ent1 (2012)
Journal Article
Turner, D., Hezwani, M., Nelson, S., Salisbury, V., & Reynolds, D. M. (2012). Characterization of the Salmonella bacteriophage vB_SenS-Ent1. Journal of General Virology, 93(9), 2046-2056. https://doi.org/10.1099/vir.0.043331-0

The bacteriophage vB_SenS-Ent1 (Ent1) is a member of the family Siphoviridae of tailed bacteriophages and infects a broad range of serovars of the enteric pathogen Salmonella enterica. The virion particle is composed of an icosahedral head 64 nm in d... Read More about Characterization of the Salmonella bacteriophage vB_SenS-Ent1.

Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production (2007)
Journal Article
Greenman, J., Nelson, S. M., Thorn, R. M., Thorn, R., Nelson, S., & Greenman, J. (2007). Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production. Antimicrobial Agents and Chemotherapy, 51(9), 3217-3224. https://doi.org/10.1128/AAC.00302-07

A bioluminescent Pseudomonas aeruginosa was incorporated into an in vitro static diffusion method to determine whether light output could be used as a measure of wound dressing efficacy. A significant linear correlation was observed between viable co... Read More about Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production.

Use of bioluminescent Escherichia coli O157:H7 to study intra-protozoan survival of bacteria within Tetrahymena pyriformis (2003)
Journal Article
Salisbury, V. C., Taylor, E. L., Cooper, A. A., Nelson, S. M., Nelson, S., Cooper, A., …Salisbury, V. (2003). Use of bioluminescent Escherichia coli O157:H7 to study intra-protozoan survival of bacteria within Tetrahymena pyriformis. FEMS Microbiology Letters, 223(1), 95-99. https://doi.org/10.1016/S0378-1097%2803%2900349-5

A method was developed that enabled real-time monitoring of the uptake and survival of bioluminescent Escherichia coli O157 within the freshwater ciliate Tetrahymena pyriformis. Constitutively bioluminescent E. coli O157 pLITE27 was cocultured with T... Read More about Use of bioluminescent Escherichia coli O157:H7 to study intra-protozoan survival of bacteria within Tetrahymena pyriformis.