Skip to main content

Research Repository

Advanced Search

A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust (2019)
Journal Article
Henderson, J., Ciesielczuk, H., Nelson, S., Wilks, M., & Cummins, M. (2020). A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust. Journal of Hospital Infection, 104(1), 12-19. https://doi.org/10.1016/j.jhin.2019.10.012

Summary Background There has been an increase in the number of carbapenemase-producing organisms documented across the UK over the past 10 years. From these, the ‘big five’ carbapenemases (KPC, OXA-48, IMP, VIM, and NDM) are the most common types r... Read More about A point prevalence study to determine the inpatient rate of carbapenemase-producing organisms at a large London NHS Trust.

Prevalence of Carbapenemase Producing Organisms in East London, UK. (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., & Nelson, S. (2019, September). Prevalence of Carbapenemase Producing Organisms in East London, UK. Poster presented at IBMS Congress 2019, Birmingham

Carbapenemases are enzymes, produced by an array of common Gram-negative organisms, which hydrolyse the carbapenem antibiotics, conferring resistance [1]. The main protagonists are the “big five” carbapenemases, KPC, OXA-48, IMP, VIM and NDM, which h... Read More about Prevalence of Carbapenemase Producing Organisms in East London, UK..

Community prevalence of carbapenemase-producing organisms in East London (2019)
Journal Article
Henderson, J., Ciesielczuk, H., Nelson, S. M., & Wilks, M. (2019). Community prevalence of carbapenemase-producing organisms in East London. Journal of Hospital Infection, 103(2), 142-146. https://doi.org/10.1016/j.jhin.2019.04.014

Background: Over the last decade there has been a rapid, worldwide increase in carbapenem resistance, which is of growing concern. The main protagonists, the carbapenemases Klebsiella pneumoniae carbapenemase (KPC), oxacillinase β-lactamase 48 (OXA-4... Read More about Community prevalence of carbapenemase-producing organisms in East London.

Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., Nelson, S., & Wilks, M. (2019, April). Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK. Poster presented at 29th European Conference of Clinical Microbiology and Infectious Disease

A point prevalence study (PPS) to determine the carriage rate of carbapenemase producing organisms (CPOs) was performed across 4 sites at Barts Health NHS Trust (BHT), encompassing 2.5 million patients across three London boroughs: Tower Hamlets, New... Read More about Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK.

An in vitro biofilm model of Staphylococcus aureus infection of bone (2019)
Journal Article
Sweeney, E., Lovering, A., Bowker, K., MacGowan, A., & Nelson, S. (2019). An in vitro biofilm model of Staphylococcus aureus infection of bone. Letters in Applied Microbiology, 68(4), 294-302. https://doi.org/10.1111/lam.13131

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an invitro model of osteomyelitis. A bioluminescent st... Read More about An in vitro biofilm model of Staphylococcus aureus infection of bone.

Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells (2019)
Journal Article
Marques, C., & Nelson, S. (2019). Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells. Letters in Applied Microbiology, 68(4), 350-359. https://doi.org/10.1111/lam.13126

© 2019 The Society for Applied Microbiology The influence of growth phase and state on the survival and recovery of Pseudomonas aeruginosa exposed to ciprofloxacin was investigated using batch culture grown planktonic cells and disaggregated biofilm... Read More about Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells.