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Graphene-based electrodes for monitoring of Estradiol (2023)
Journal Article
Musa, A. M., Kiely, J., Luxton, R., & Honeychurch, K. C. (2023). Graphene-based electrodes for monitoring of Estradiol. Chemosensors, 11(6), 337. https://doi.org/10.3390/chemosensors11060337

This study explores the potential use of graphene-based electrodes in the electrochemical determination of estradiol using amperometric techniques as a simple, enzyme-free approach. Graphene, a carbon-based nanomaterial, has been extensively investig... Read More about Graphene-based electrodes for monitoring of Estradiol.

Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study (2023)
Journal Article
Harrison, O. J., Monnier, B., Regan, E., West, D., Dykes, H. B., Davey, J. S., …Luxton, R. (2023). Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study. Sensing and Bio-Sensing Research, 41, Article 100566. https://doi.org/10.1016/j.sbsr.2023.100566

Expensive, time-consuming and labour-intensive solvent-extraction and liquid-chromatography methods are the industry's current gold standard for antibiotic residue quantification. A novel immunoassay methodology and system for the rapid detection of... Read More about Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study.

An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol (2023)
Journal Article
Musa, A., Kiely, J., Luxton, R., & Honeychurch, K. C. (2023). An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol. Biosensors, 13(4), Article 491. https://doi.org/10.3390/bios13040491

In this study, a screen-printed electrode (SPE) modified with gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes (rGO-AuNPs/CNT/SPE) was used for the determination of estradiol (E2). The AuNPs were produced through an eco-friendly me... Read More about An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol.

Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring (2022)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2022). Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring. Biosensors and Bioelectronics, 12, Article 100286. https://doi.org/10.1016/j.biosx.2022.100286

Despite the growing evidence of the benefits of total-intravenous anaesthesia using propofol compared to conventional volatile-based anaesthesia, both in terms of environmental impact and patient outcomes, the majority of administered general anaesth... Read More about Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring.

Modeling peptide nucleic acid binding enthalpies using MM-GBSA (2022)
Journal Article
Goodman, J., Attwood, D., Kiely, J., Coladas Mato, P., & Luxton, R. (2022). Modeling peptide nucleic acid binding enthalpies using MM-GBSA. Journal of Physical Chemistry B, 126(46), 9528-9538. https://doi.org/10.1021/acs.jpcb.2c05547

The binding enthalpies of peptide nucleic acid (PNA) homoduplexes were predicted using a molecular mechanics generalized Born surface area approach. Using the nucleic acid nearest-neighbor model, these were decomposed into sequence parameters which c... Read More about Modeling peptide nucleic acid binding enthalpies using MM-GBSA.

Modelling a dynamic magneto-agglutination bioassay (2022)
Journal Article
Hughes, R., Fishman, A., Lamb-Riddell, K., Sleigh Muñoz, V., Champneys, A., Kiely, J., & Luxton, R. (2023). Modelling a dynamic magneto-agglutination bioassay. Biosensors and Bioelectronics, 222, 114745. https://doi.org/10.1016/j.bios.2022.114745

The process of developing an end-to-end model of a magneto-immunoassay is described, simulating the agglutination effect due to the specific binding of bacteria to paramagnetic particles. After establishing the properties of the dose-specific aggluti... Read More about Modelling a dynamic magneto-agglutination bioassay.

Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor (2022)
Journal Article
Eveness, J., Cao, L., Kiely, J., & Luxton, R. (2022). Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor. Journal of Electroanalytical Chemistry, 906, Article 116003. https://doi.org/10.1016/j.jelechem.2021.116003

This paper describes the development of an equivalent electrical circuit (EEC) model of a unique co-planar electrode PET-ZnO biosensor platform. This non-faradaic ZnO biosensor had a PET insulating layer between the electrodes and the active ZnO sens... Read More about Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor.

Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications (2021)
Journal Article
Yue, X., Kiely, J., Luxton, R., Chen, B., McLeod, C. N., & Drakakis, E. M. (2022). Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications. IEEE Sensors Journal, 22(3), 2347-2357. https://doi.org/10.1109/JSEN.2021.3136705

A bio-sensing scheme, which acquires impedance information of a capacitive biosensor by using the reflected RF signal from a surface acoustic wave (SAW) resonator connected to the biosensor, is proposed. This technique requires no power to be supplie... Read More about Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications.

Classification of the mechanism of toxicity as applied to human cell line ECV304 (2020)
Journal Article
Djawad, Y. A., Kiely, J., & Luxton, R. (2021). Classification of the mechanism of toxicity as applied to human cell line ECV304. Computer Methods in Biomechanics and Biomedical Engineering, 24(9), 933-944. https://doi.org/10.1080/10255842.2020.1861255

© 2020 Informa UK Limited, trading as Taylor & Francis Group. The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting... Read More about Classification of the mechanism of toxicity as applied to human cell line ECV304.

A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article
Gasser, A., Eveness, J., Kiely, J., Attwood, D., & Luxton, R. (2020). A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing. Bioelectrochemistry, 133, 107448. https://doi.org/10.1016/j.bioelechem.2019.107448

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement (2017)
Journal Article
Ahmad, M., Iqbal, M. A., Kiely, J., Luxton, R. W., & Jabeen, M. (2017). Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement. Journal of Physics and Chemistry of Solids, 104, 281-285. https://doi.org/10.1016/j.jpcs.2017.01.006

© 2017 Elsevier Ltd 50nm ZnO nanowires were grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrates by adapting facile aqueous growth technique using low temperature and vacuum conditions. Prior to growth of ZnO nanowires,... Read More about Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement.

Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode (2015)
Journal Article
Luxton, R., Ahmad, M., Kiely, J., Luxton, R. W., Jabeen, M., & Khalid, M. (2016). Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode. Sensing and Bio-Sensing Research, 7, 141-145. https://doi.org/10.1016/j.sbsr.2015.12.005

© 2015. Facile aqueous growth technique was adopted to grow diameter controlled 150 nm ZnO nanowires on an ITO (indium tin oxide) coated PET (poly ethylene terephthalate) substrate. Prior to nanowire growth, a pure wurtazite structured ZnO seed layer... Read More about Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode.

Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs (2014)
Journal Article
Madeira, M. S., Pires, V. M., Alfaia, C. M., Luxton, R., Doran, O., Bessa, R. J., & Prates, J. A. (2014). Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs. British Journal of Nutrition, 111(9), 1521-1535. https://doi.org/10.1017/S0007114513004029

The cumulative effects of dietary arginine, leucine and protein levels on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig longissimus lumborum muscle and subcutaneous adipose tissue (SAT) were investig... Read More about Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs.

An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen (2014)
Journal Article
Barnett, J., Wraith, P., Kiely, J., Persad, R., Hurley, K., Hawkins, P., & Luxton, R. W. (2014). An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen. Biosensors, 4(3), 204-220. https://doi.org/10.3390/bios4030204

We describe the detection characteristics of a device the Resonant Coil Magnetometer (RCM) to quantify paramagnetic particles (PMPs) in immunochromatographic (lateral flow) assays. Lateral flow assays were developed using PMPs for the measurement of... Read More about An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article
Luxton, R., Sharif, E., Syarif, E., Kiely, J., Wraith, P., & Luxton, R. W. (2013). The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins. IEEE Transactions on Biomedical Engineering, 60(5), 1209-1216. https://doi.org/10.1109/TBME.2012.2228642

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Microfabricated glucose biosensor for culture welloperation (2013)
Journal Article
Hart, J. P., Luxton, R., Xu, J., Griffiths, J., Sage, I., Tuffin, R., …Hart, J. P. (2013). Microfabricated glucose biosensor for culture welloperation. Biosensors and Bioelectronics, 42(1), 668-677. https://doi.org/10.1016/j.bios.2012.11.032

A water-based carbon screen-printing ink formulation, containing the redox mediator cobalt phthalocyanine (CoPC) and the enzyme glucose oxidase (GOx), was investigated for its suitability to fabricate glucose microbiosensors in a 96-well microplate f... Read More about Microfabricated glucose biosensor for culture welloperation.

Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles (2013)
Journal Article
Sharif, E., Kiely, J., & Luxton, R. (2013). Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles. Journal of Immunological Methods, 388(1-2), 78-85. https://doi.org/10.1016/j.jim.2012.11.015

Magnetic immunoassays have been shown to have similar detection limits to conventional immunoassays, with the advantage of reduced total assay time. The aim of this study was to demonstrate that an integrated lysis and measurement system could be use... Read More about Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles.