All Outputs (103)

Investigating Browne's method (2021)
Presentation / Conference
Obodo, S., Toher, D., & White, P. (2021, September). Investigating Browne's method. Poster presented at Statistics at Bristol: Future Reserach and You 2021, Bristol

Results supports Browne’s procedure of pilot sample size determination. However the data reveals that the procedure underestimates and overestimates sample size. Fig. 1 shows 𝛼 and 𝛽 have no practical effect on degree of excess which increases as... Read More about Investigating Browne's method.

Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study (2021)
Journal Article
Johnson, L., Holcombe, C., O’Donoghue, J. M., Jeevan, R., Browne, J., Fairbrother, P., …Potter, S. (2021). Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study. BMJ Open, 11(8), Article e054055. https://doi.org/10.1136/bmjopen-2021-054055

Introduction Breast reconstruction (BR) is offered to improve quality of life for women with breast cancer undergoing mastectomy. As most women will be long-Term breast cancer survivors, high-quality information regarding the long-Term outcomes of di... Read More about Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study.

Patient reported psychosocial functioning following successful ptosis surgery (2021)
Journal Article
Richards, H., Jenkinson, E., White, P., & Harrad, R. (2021). Patient reported psychosocial functioning following successful ptosis surgery. Eye, 36, 1651–1655. https://doi.org/10.1038/s41433-021-01685-w

Background: Ptosis may result in increased anxiety, appearance-related distress and social avoidance, and impacts visual function. Previous work demonstrates the benefits of ptosis surgery for health-related quality of life, but there is a paucity of... Read More about Patient reported psychosocial functioning following successful ptosis surgery.

Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial (2021)
Journal Article
Walker, S. P., Keenan, E., Bintcliffe, O., Stanton, A. E., Roberts, M., Pepperell, J., …Maskell, N. A. (2021). Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial. European Respiratory Journal, 57(6), Article 2003375. https://doi.org/10.1183/13993003.03375-2020

Secondary spontaneous pneumothorax (SSP) is traditionally managed with an intercostal chest tube attached to an underwater seal. We investigated whether use of a one-way flutter valve shortened patients' length of stay (LoS). This open-label randomis... Read More about Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial.

“They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction (2021)
Journal Article
Tollow, P., Paraskeva, N., Clarke, A., White, P., Powell, J., Cox, D., & Harcourt, D. (in press). “They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction. European Journal of Cancer Care, Article e13464. https://doi.org/10.1111/ecc.13464

Objective: Many women choose to have breast reconstruction after mastectomy, however, decision-making can be difficult and expectations are often unmet. The PEGASUS intervention (Patient Expectations and Goals: Assisting Shared Understanding of Surge... Read More about “They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction.

Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study) (2021)
Journal Article
Davies, C., Holcombe, C., Skillman, J., Whisker, L., Hollingworth, W., Conefrey, C., …Potter, S. (2021). Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study). BMJ Open, 11(4), Article e046622. https://doi.org/10.1136/bmjopen-2020-046622

Introduction: Approximately 40% of the 55,000 women diagnosed with breast cancer each year in the UK undergo mastectomy because they are considered unsuitable for standard breast conserving surgery (BCS) due to tumour size or multiple tumour foci. Ma... Read More about Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study).

Acceptability and preliminary efficacy of a school-based body image intervention in urban India: A pilot randomised controlled trial (2021)
Journal Article
Garbett, K., Lewis-Smith, H., Chaudhry, A., Schroff, H., Dhillon, M., White, P., & Diedrichs, P. C. (2021). Acceptability and preliminary efficacy of a school-based body image intervention in urban India: A pilot randomised controlled trial. Body Image, 37, 282-290. https://doi.org/10.1016/j.bodyim.2021.02.011

This pilot study evaluated the acceptability and preliminary efficacy of a culturally adapted school-based body image intervention, Dove Confident Me, for use in urban India. Two private schools in New Delhi were randomly assigned at the school level... Read More about Acceptability and preliminary efficacy of a school-based body image intervention in urban India: A pilot randomised controlled trial.

Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma (2021)
Journal Article
Ren, X., Barber, H., Tofias, A., Lander, B., Daniels, A., Gong, J., …Kurian, K. M. (2021). Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma. Journal of Oncology, 2021, Article 8819702. https://doi.org/10.1155/2021/8819702

Introduction. Glioblastoma (GBM) is the most common primary adult brain tumour with a median overall survival (OS) of 12-15 months. Molecular characterization of multiple immunooncology targets in GBM may help target novel immunotherapeutic strategie... Read More about Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma.

A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2021)
Journal Article
Challapalli, A., Masson, S., White, P., Dailami, N., Pearson, S., Rowe, E., …Bahl, A. (2021). A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder. Clinical Genitourinary Cancer, 19(4), P325-332. https://doi.org/10.1016/j.clgc.2021.02.001

Introduction: Neoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer. However, response rates and survival remain suboptimal. We evaluated the efficacy, safety, and tolerability of cisplatin plus caba... Read More about A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant (2021)
Journal Article
Murray, J. R., Smith, J. R., Bray, R., Robinson, J. R., White, P., & Porteous, A. J. (2021). Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant. Knee, 29, 101-109. https://doi.org/10.1016/j.knee.2020.12.032

Background: Lateral unicompartmental arthroplasty (UKA) constitutes only 5–10% of all unicompartmental replacements performed. Whilst the short and medium term benefits are well documented, there remains concern regarding the higher revision rate whe... Read More about Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant.

St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up (2021)
Journal Article
Porteous, A. J., Smith, J. R., Bray, R., Robinson, J. R., White, P., & Murray, J. R. (2022). St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up. Knee Surgery, Sports Traumatology, Arthroscopy, 30, 800–808. https://doi.org/10.1007/s00167-021-06454-6

Purpose: The peri-operative and short-term benefits of unicompartmental knee arthroplasty (UKA) are well supported in the literature. However, there remains concern regarding the higher revision rate when compared with total knee replacement. This ma... Read More about St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up.

Differential expression of the BCAT isoforms between breast cancer subtypes (2020)
Journal Article
Shafei, M. A., Flemban, A., Daly, C., Kendrick, P., White, P., Dean, S., …Conway, M. E. (2021). Differential expression of the BCAT isoforms between breast cancer subtypes. Breast Cancer, 28, 592–607. https://doi.org/10.1007/s12282-020-01197-7

© 2020, The Author(s). Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where... Read More about Differential expression of the BCAT isoforms between breast cancer subtypes.

Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients (2020)
Journal Article
Zielinska, H. A., Daly, C. S., Alghamdi, A., Bahl, A., Sohail, M., White, P., …Perks, C. M. (2020). Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients. Cancers, 12(12), 1-13. https://doi.org/10.3390/cancers12123821

Insulin-like growth factor binding protein 3 (IGFBP-3) plays a key role in breast cancer progression and was recently shown to bind to the chaperone protein glucose-regulated protein 78 (GRP78); however, the clinical significance of this association... Read More about Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients.

Challenges and reflections from a multi-centre trial of a psycho-oncology intervention to support shared decision-making in breast reconstruction (2020)
Journal Article
Tollow, P., Paraskeva, N., Clarke, A., White, P., Powell, J., Cox, D., & Harcourt, D. (2021). Challenges and reflections from a multi-centre trial of a psycho-oncology intervention to support shared decision-making in breast reconstruction. European Journal of Cancer Care, 30(2), Article e13384. https://doi.org/10.1111/ecc.13384

Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service (2020)
Journal Article
Mitchell, E., Coary, R., White, P., Farrow, E., Crees, A., Beedham, W., …Shipway, D. (2020). Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service. Geriatrics, 5(4), Article 78. https://doi.org/10.3390/geriatrics5040078

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Older adults undergoing vascular surgery are particularly vulnerable to adverse outcomes by virtue of their vascular risk factors and medical comorbidities. This study aimed to determine the i... Read More about Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service.

How many words make a sample? Determining the minimum number of word tokens needed in connected speech samples for child speech assessment (2020)
Journal Article
Wren, Y., Titterington, J., & White, P. (2021). How many words make a sample? Determining the minimum number of word tokens needed in connected speech samples for child speech assessment. Clinical Linguistics & Phonetics, 35(8), 761-778. https://doi.org/10.1080/02699206.2020.1827458

Connected speech (CS) is an important component of child speech assessment in both clinical practice and research. There is debate in the literature regarding what size sample of CS is required to facilitate reliable measures of speech output. The ai... Read More about How many words make a sample? Determining the minimum number of word tokens needed in connected speech samples for child speech assessment.

Parent-reported socioemotional and cognitive development in children with a cleft lip and/or palate at 18 months: Findings from a UK birth cohort (2020)
Journal Article
Costa, B., White, P., Kiff, J. D., Davies, A., & Stock, N. M. (2021). Parent-reported socioemotional and cognitive development in children with a cleft lip and/or palate at 18 months: Findings from a UK birth cohort. Child: Care, Health and Development, 47(1), 31-39. https://doi.org/10.1111/cch.12813

Background: One of the most common congenital conditions in the world, cleft lip and/or palate (CL/P) has been shown to potentially impact long-term physical and developmental outcomes in affected children. However, little is known about the factors... Read More about Parent-reported socioemotional and cognitive development in children with a cleft lip and/or palate at 18 months: Findings from a UK birth cohort.

Factors associated with advanced colorectal cancer differ between young and older adults in England: A population-based cohort study (2020)
Journal Article
Chambers, A. C., Dixon, S. W., White, P., Thomas, M. G., Williams, A. C., & Messenger, D. E. (2020). Factors associated with advanced colorectal cancer differ between young and older adults in England: A population-based cohort study. Colorectal Disease, 22(12), 2087-2097. https://doi.org/10.1111/codi.15361

Aim: Advanced stage presentation of colorectal cancer is associated with poorer survival outcomes, particularly among young adults. This study aimed to determine whether demographic risk factors for advanced stage presentation differed between young... Read More about Factors associated with advanced colorectal cancer differ between young and older adults in England: A population-based cohort study.

Illicit drug contamination of the Bristol Pound local currency (2020)
Journal Article
Bowdler, P., Gale, E., Bryant, F., Codd, S., Hudd, S., Longden, R., …Honeychurch, K. C. (2020). Illicit drug contamination of the Bristol Pound local currency. Forensic Science International, 316, Article 110469. https://doi.org/10.1016/j.forsciint.2020.110469

Reports have shown the prevalence of the contamination of banknotes with a number of different drugs. These studies have focused on investigating drug contamination levels on currency which is either nationally or even international distributed. To p... Read More about Illicit drug contamination of the Bristol Pound local currency.

Pathological response rates and quality of life outcomes of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle-invasive transitional cell carcinoma of the urinary bladder (2020)
Journal Article
Challapalli, A., Masson, S., White, P., Dailami, N., Pearson, S., Rowe, E., …Bahl, A. (2020). Pathological response rates and quality of life outcomes of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle-invasive transitional cell carcinoma of the urinary bladder. Journal of Clinical Oncology, 38(15 Suppl.), 5030-5030. https://doi.org/10.1200/JCO.2020.38.15_suppl.5030